scholarly journals Development of GFAP positive Cells and Reactive Changes Associated with Cystic Lesions in HTX Rat Brain

1990 ◽  
Vol 30 (7) ◽  
pp. 445-450 ◽  
Author(s):  
Yasuji YOSHIDA ◽  
Goyo KOYA ◽  
Kouki TAMAYAMA ◽  
Toshiro KUMANISHI ◽  
Satoshi ABE
Keyword(s):  
Rat Brain ◽  
Cystic Lesions ◽  
Reactive Changes

Reactive Changes in the Cellular Elements of the Rat Brain in Different Conditions of Circulatory Hypoxia

2014 ◽  
Vol 44 (6) ◽  
pp. 606-613 ◽  
Author(s):  
A. V. Droblenkov ◽  
N. V. Naumov ◽  
M. V. Monid ◽  
E. I. Val’kovich ◽  
P. D. Shabanov
Keyword(s):  
Rat Brain ◽  
Circulatory Hypoxia ◽  
Reactive Changes

scholarly journals Immunohistochemical analysis of microglial changes in the experimental acute hepatic encephalopathy

Pathologia ◽  
2021 ◽  
Vol 18 (1) ◽  
pp. 33-38
Author(s):  
T. V. Shulyatnikova
Keyword(s):  
Hepatic Encephalopathy ◽  
White Matter ◽  
Liver Failure ◽  
Rat Brain ◽  
Subcortical White Matter ◽  
Time Dependent ◽  
Brain Cells ◽  
Caudate Putamen ◽  
Reactive Changes ◽  
The Brain

Hepatic encephalopathy (HE) is a syndrome of impaired brain function in patients with advanced liver failure and it manifests in form of psychometric tests alterations up to decreased consciousness and coma. The current knowledge about HE mainly focused on the theory of ammonia neurotoxicity and neuroinflammation. Microglia being resident innate immune cells of the brain when activated are responsible for the neuroinflammatory reactions. The aim – immunohistochemical study of the microglial changes in different rat brain regions in conditions of experimental acute HE (AHE). Materials and methods. We used acetaminophen induced liver failure model in Wistar rats. Four from 10 animals that survived up to 24 h after acetaminophen injection constituted “compensated group”; 6 animals which died within 24 h – “decompensated group”. Microglial reactive changes were analysed by the evaluation of the relative area (S rel., %) of CD68+ expression in the brain cells not associated with meninges and vessels, as well as the changing in shape and number of these cells. Results. Acetaminophen-induced AHE in rats was characterized by the regional- and time-dependent dynamic increase in CD68 expression level in the rat brain in form of significant (relatively to control) increase of CD68+ S rel. in brain cells and the number of such cells. The medians of CD68+ S rel. and their numbers in significantly changed regions of non-survived rats were, respectively: subcortical white matter – 0.24 (0.20; 0.26) and 11.00 (8.00; 13.00); thalamus – 0.13 (0.90; 0.18) and 6.00 (3.00; 7.00); caudate/putamen – 0.13 (0.12; 0.18) and 7.00 (4.00; 11.00) – all indicators were statistically significant compared to control. In the survived animals, indicators were, respectively: subcortical white matter – 0.24 (0.16; 0,26) and 10.00 (8.00; 12.00); caudate/putamen – 0.12 (0.10; 0.15) and 6.00 (4.00; 10.00) – the differences were significant compared to control. Conclusions. The highest and significant indicators were revealed at 24 h (compared to earlier time points) of the experiment in the white matter, thalamus and caudate/putamen. This fact reflects time-dependent dynamic boosting of reactive changes in microglia and presumably may indicate the regions of the most active neuroinflammatory response within the brain parenchyma in the conditions of AHE. The appearing of a small percentage of cells with amoeboid transformation among CD68+-cells may mean partial functional insufficiency of such cells due to probable suppressive impact of ammonia or other influencing factors, as well as insignificance of the material that needs to be phagocytosed under established conditions.

cDNA cloning and expression of a gamma-aminobutyric acidA receptor epsilon-subunit in rat brain

2000 ◽  
Vol 12 (12) ◽  
pp. 4318-4330 ◽  
Author(s):  
Nathalie Moragues ◽  
Philippe Ciofi ◽  
Pierrette Lafon ◽  
Marie-Francoise Odessa ◽  
Gerard Tramu ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cdna Cloning ◽  
Cloning And Expression ◽  
Epsilon Subunit

Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain

2001 ◽  
Vol 13 (1) ◽  
pp. 119-128 ◽  
Author(s):  
Vemuganti L. Raghavendra Rao ◽  
Aclan Dogan ◽  
Kellie K. Bowen ◽  
Kathryn G. Todd ◽  
Robert J. Dempsey
Keyword(s):  
Rat Brain ◽  
Neuronal Damage ◽  
Traumatic Injury ◽  
Glutamate Transporter ◽  
Glial Glutamate Transporter ◽  
Antisense Knockdown

Contribution of MR imaging and CEA cystic fluid level to the differential diagnosis of cystic lesions of the pancreas

2001 ◽  
Vol 120 (5) ◽  
pp. A764-A764
Author(s):  
M DELHAYE ◽  
C WINANT ◽  
D DEGRE ◽  
B GULBIS ◽  
C GERVY ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Cystic Lesions ◽  
Fluid Level ◽  
Cystic Fluid

Inhibition of Rat Brain Monoamine Oxidase Activities by Psoralen and Isopsoralen: Implications for the Treatment of Affective Disorders

2001 ◽  
Vol 88 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Ling Dong Kong ◽  
Ren Xiang Tan ◽  
Anthony Yiu Ho Woo ◽  
Christopher Hon Ki Cheng2Note
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Affective Disorders ◽  
Brain Monoamine
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