scholarly journals Cell-mediated Immunity of Experimental Brain Tumors

1983 ◽  
Vol 23 (2) ◽  
pp. 109-115
Author(s):  
Katsuzo KIYA ◽  
Hirofumi OKAMOTO ◽  
Kiyoshi HARADA ◽  
Tohru UOZUMI ◽  
Tetsuya TOGE ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Cell Mediated Immunity ◽  
Experimental Brain Tumors

scholarly journals Imaging Experimental Brain Tumors with 1-Aminocyclopentane Carboxylic Acid and Alpha-Aminoisobutyric Acid: Comparison to Fluorodeoxyglucose and Diethylenetriaminepentaacetic Acid in Morphologically Defined Tumor Regions

1997 ◽  
Vol 17 (11) ◽  
pp. 1239-1253 ◽  
Author(s):  
Hisao Uehara ◽  
Tadashi Miyagawa ◽  
Juri Tjuvajev ◽  
Revathi Joshi ◽  
Bradley Beattie ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Brain Tumors ◽  
Vascular Permeability ◽  
Cell Density ◽  
Low Grade ◽  
Acid Uptake ◽  
Diethylenetriaminepentaacetic Acid ◽  
Experimental Brain Tumors ◽  
Walker 256 ◽  
Walker 256 Tumors

The goal of this study was to evaluate the differences and define the advantages of imaging experimental brain tumors in rats with two nonmetabolized amino acids, 1-aminocyclopentane carboxylic (ACPC) acid and α-aminoisobutyric (AIB) acid compared with imaging with fluorodeoxyglucose (FDG) or the gallium-diethylenetriaminepentaacetic acid chelate (Ga-DTPA). 1-aminocyclopentane carboxylic acid, AIB, and FDG autoradiograms were obtained 60 minutes after intravenous injection to simulate positron emission tomography (PET) imaging, whereas the Ga-DTPA autoradiograms were obtained 5 or 10 minutes after injection to simulate gadolinium (Gd)-DTPA–enhanced magnetic resonance (MR) images. Three experimental tumors were studied (C6, RG2, and Walker 256) to provide a range of tumor types. Triple-label quantitative autoradiography was performed, and parametric images of the apparent distribution volume (Va, mL/g) for ACPC or AIB, relative glucose metabolism (R, μmol/100 g/min), vascular permeability to Ga-DTPA (K1, μL/min/g), and histology were obtained from the same tissue section. The four images were registered in an image array processor, and regions of interest in tumor and contralateral brain were defined on morphologic criteria (histology) and were transferred to the autoradiographic images. A comparative analysis of all measured values was performed. The location and morphologic characteristics of the tumor had an effect on the images and measurements of Va, R, and K1. Meningeal extensions of all three tumors consistently had the highest amino acid uptake (Va) and vascular permeability (K1) values, and subcortical portions of the tumors usually had the lowest values. Va and R (FDG) values generally were higher in tumor regions with high-cell density and lower in regions with low-cell density. Tumor areas identified as “impending” necrosis on morphologic criteria consistently had high R values, but little or no change in Va or K1. Tumor necrosis was seen consistently only in the larger Walker 256 tumors; low values of R and Va for AIB (less for ACPC) were measured in the necrotic-appearing regions, whereas K1 was not different from the mean tumor value. The highest correlations were observed between vascular permeability (K1 for Ga-DTPA) and Va for AIB in all three tumors; little or no correlation between vascular permeability and R was observed. The advantages of ACPC and AIB imaging were most convincingly demonstrated in C6 gliomas and in Walker 256 tumors. 1-aminocyclopentane was substantially better than FDG or Ga-DTPA for identifying tumor infiltration of adjacent brain tissue beyond the macroscopic border of the tumor; ACPC also may be useful for identifying low-grade tumors with an intact blood–brain barrier. Contrast-enhancing regions of the tumors were visualized more clearly with AIB than with FDG or Ga-DTPA; viable and necrotic-appearing tumor regions could be distinguished more readily with AIB than with FDG. [11C]-labeled ACPC and AIB are likely to have similar advantages for imaging human brain tumors with PET.

Proton MR Spectroscopy of Experimental Brain Tumors in vivo

1994 ◽  
pp. 350-352
Author(s):  
Michael L. Gyngell ◽  
T. Els ◽  
M. Hoehn-Berlage ◽  
K.-A. Hossmann
Keyword(s):  
Brain Tumors ◽  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy ◽  
Experimental Brain Tumors

Gene therapy of experimental brain tumors using neural progenitor cells

10.1038/74710 ◽  
2000 ◽  
Vol 6 (4) ◽  
pp. 447-450 ◽  
Author(s):  
Sara Benedetti ◽  
Barbara Pirola ◽  
Bianca Pollo ◽  
Lorenzo Magrassi ◽  
Maria Grazia Bruzzone ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Brain Tumors ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Experimental Brain Tumors

scholarly journals Inhibition of methionine uptake byCIS-diamminedichloroplatinum (II) in experimental brain tumors

1996 ◽  
Vol 67 (5) ◽  
pp. 681-683 ◽  
Author(s):  
Katsuyoshi Mineura ◽  
Toshio Sasajima ◽  
Hiroyasu Sasajima ◽  
Masayoshi Kowada
Keyword(s):  
Brain Tumors ◽  
Experimental Brain Tumors ◽  
Methionine Uptake
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