scholarly journals 9. The Motor Responces of the Electrical Stimulation of the Thalamus (Oral Ventral Nucleus), Red Nucleus, Substantia Nigra and Subthalamic Nucleus during Stereotaxic Operations

1968 ◽  
Vol 10 ◽  
pp. 313-314
Author(s):  
Norihiko KOMAI ◽  
Tsuyoshi KURIYAMA ◽  
Kishio MATSUMOTO ◽  
Hideo NISHINA ◽  
Takuhei KIDO
Keyword(s):  
Electrical Stimulation ◽  
Substantia Nigra ◽  
Subthalamic Nucleus ◽  
Red Nucleus ◽  
Ventral Nucleus ◽  
Stimulation Of

Functional Metabolic Mapping of the Rat Brain during Unilateral Electrical Stimulation of the Subthalamic Nucleus

1994 ◽  
Vol 14 (1) ◽  
pp. 132-144 ◽  
Author(s):  
Minas Tzagournissakis ◽  
Catherine R. Dermon ◽  
Helen E. Savaki
Keyword(s):  
Electrical Stimulation ◽  
Substantia Nigra ◽  
Globus Pallidus ◽  
Subthalamic Nucleus ◽  
Limbic System ◽  
Thalamic Nucleus ◽  
Metabolic Activation ◽  
Posterior Cingulate Cortex ◽  
Control Group ◽  
Stimulation Of

The alterations in local metabolic activity of several anatomically distinct brain areas were investigated by means of the quantitative autoradiographic 2-deoxy-D-[1-14C]glucose method in awake rats during unilateral electrical stimulation of the subthalamic nucleus (STH). Unilateral electrical stimulation of the STH induced local metabolic activation (by 70% as compared with the control group), as well as distal metabolic activations in the substantia nigra reticulata (by 34%), globus pallidus (by 19%), entopeduncular nucleus (by 18%), deep layers of the superior colliculi (by 15%), and parafascicular thalamic nucleus (by 18%), ipsilaterally to the stimulated side. The ventrolateral motor thalamic nucleus as well as the limbic components, posterior cingulate cortex, and anteroventral thalamic nucleus displayed bilateral metabolic activations (by 20–28%). These results indicate that, in addition to its known ipsilateral motor connections, each STH is functionally related to the limbic system bilaterally. It is suggested that the STH is a site where the central motor information is accessible to the limbic system. Quantitative image analysis of individual serial sections in the STH, substantia nigra, and globus pallidus revealed a consistent dorsoventral pattern of topographic interrelations. Stimulation of either the dorsal or the ventral subdivision of the STH induced always stronger activation in the dorsal compartment of the substantia nigra and in the ventral compartment of the globus pallidus. These results suggest that the earlier-described inversion of the dorsoventral functional correspondence between the substantia nigra and globus pallidus may be partly mediated via the subthalamic nerve cells projecting collateral axons to both these areas.

Role of the Subthalamic Nucleus in Cannabinoid Actions in the Substantia Nigra of the Rat

1997 ◽  
Vol 77 (3) ◽  
pp. 1635-1638 ◽  
Author(s):  
M. Clara Sañudo-Peña ◽  
J. Michael Walker
Keyword(s):  
Substantia Nigra ◽  
Subthalamic Nucleus ◽  
Cannabinoid Receptors ◽  
Excitatory Input ◽  
Physiological Regulation ◽  
Cannabinoid Antagonist ◽  
Substantia Nigra Reticulata ◽  
Cannabinoid Agonist ◽  
Stimulation Of

Sañudo-Peña, M. Clara and J. Michael Walker. Role of the subthalamic nucleus in cannabinoid actions in the substantia nigra of the rat. J. Neurophysiol. 77: 1635–1638, 1997. The effect of cannabinoids on the excitatory input to the substantia nigra reticulata (SNr) from the subthalamic nucleus was explored. For this purpose a knife cut was performed rostral to the subthalamic nucleus to isolate the subthalamic nucleus and the SNr from the striatum, a major source of cannabinoid receptors to the SNr. The data showed that the cannabinoid agonist WIN55,212-2 blocked the increase in the firing rate of SNr neurons induced by stimulation of the subthalamic nucleus with bicuculline. Furthermore, the cannabinoid antagonist SR141716A antagonized the effect of the cannabinoid agonist. This study showed that cannabinoids regulate not only the striatonigral pathway, as previously reported, but also the subthalamonigral pathway. The opposite influences of these two inputs to the SNr, inhibitory and excitatory respectively, suggest that endogenous cannabinoids play a major role in the physiological regulation of the SNr.

The effects of haloperidol and clozapine on circling induced by electrical stimulation of the substantia nigra and the ventromedial tegmentum

1978 ◽  
Vol 17 (11) ◽  
pp. 943-946 ◽  
Author(s):  
M. Roffman ◽  
P.S. Bernard ◽  
K.M. Dawson ◽  
R.E. Sobiski ◽  
J.K. Saelens
Keyword(s):  
Electrical Stimulation ◽  
Substantia Nigra ◽  
Stimulation Of
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