Implications of short-term high-fat intake on gut, liver, and cardiovascular health of adolescent male rats

2020 ◽  
Author(s):  
Karen Sweazea ◽  
Meli'sa Crawford ◽  
Corrie Whisner ◽  
Layla Al-Nakkash
Keyword(s):  
Cardiovascular Health ◽  
Male Rats ◽  
Adolescent Male ◽  
Fat Intake ◽  
High Fat ◽  
Short Term

Short-term fluoxetine treatment induces neuroendocrine and behavioral anxiogenic-like responses in adolescent male rats

2014 ◽  
Vol 233 (3) ◽  
pp. 983-995 ◽  
Author(s):  
Francisca Gomez ◽  
César Venero ◽  
María-Paz Viveros ◽  
Luis García-García
Keyword(s):  
Male Rats ◽  
Adolescent Male ◽  
Short Term ◽  
Fluoxetine Treatment

Chronic high-fat diet increases acute neuroendocrine stress response independently of prenatal dexamethasone treatment in male rats

2013 ◽  
Vol 26 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Anders Abildgaard ◽  
Sten Lund ◽  
Karin S Hougaard
Keyword(s):  
Stress Response ◽  
Hpa Axis ◽  
High Fat Diet ◽  
Forced Swim Test ◽  
Male Rats ◽  
Adolescent Male ◽  
Late Adolescent ◽  
High Fat ◽  
Obesity And Diabetes ◽  
Increased Risk

ObjectiveIntrauterine growth restriction (IUGR) has been associated with metabolic disorders later in life such as obesity and diabetes as well as psychiatric disorders such as depression and schizophrenia. Therefore, we wanted to investigate whether behavioural, metabolic or neuroendocrine abnormalities could be provoked or exacerbated by a high-fat diet (HFD) in an experimental model of IUGR.MethodsPregnant dams were exposed to dexamethasone (DEX) in the third gestational week to induce IUGR. Late adolescent male offspring of DEX- and vehicle-treated dams were then fed a HFD or standard chow for 8 weeks and subjected to a variety of assessments.ResultsOnly diet affected the hypothalamus-pituitary-adrenal (HPA) axis stress response, as HFD doubled the observed corticosterone levels following acute restraint. HFD and prenatal DEX exposure concomitantly exacerbated depressive-like behaviour in the forced swim test, even though no interaction was seen. Prenatal DEX treatment tended to increase the basal acoustic startle response (ASR), while an interaction between HFD and DEX was present in the ASR pre-pulse inhibition suggestive of fundamental changes in neuronal gating mechanisms. Metabolic parameters were only affected by diet, as HFD increased fasting glucose and insulin levels.ConclusionWe conclude that chronic HFD may be more important in programming of the HPA axis stress responsiveness than an adverse foetal environment and therefore potentially implies an increased risk for developing psychiatric and metabolic disease.

High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat

1997 ◽  
Vol 273 (6) ◽  
pp. E1168-E1177 ◽  
Author(s):  
Beth M. Tannenbaum ◽  
David N. Brindley ◽  
Gloria S. Tannenbaum ◽  
Mary F. Dallman ◽  
M. Dawn McArthur ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Dietary Fat ◽  
High Fat Diet ◽  
Male Rats ◽  
Fat Intake ◽  
High Fat ◽  
Hypothalamic Pituitary Adrenal ◽  
Resistance To Insulin ◽  
Artery Disease ◽  
Fat Feeding

High-fat feeding induces insulin resistance and increases the risk for the development of diabetes and coronary artery disease. Glucocorticoids exacerbate this hyperinsulinemic state, rendering an individual at further risk for chronic disease. The present studies were undertaken to determine whether dietary fat-induced increases in corticosterone (B) reflect alterations in the regulatory components of the hypothalamic-pituitary-adrenal (HPA) axis. Adult male rats were maintained on a high-fat (20%) or control (4%) diet for varying periods of time. Marked elevations in light-phase spontaneous basal B levels were evident as early as 7 days after fat diet onset, and B concentrations remained significantly elevated up to 21 days after fat diet onset compared with controls. In contrast, there were no significant effects on any parameters of spontaneous growth hormone secretory profiles, thus providing support for the specificity of the effects on the HPA axis. In a second study, all groups of rats fed the high-fat diet for 1, 9, or 12 wk exhibited significantly elevated levels of plasma adrenocorticotropic hormone, B, fatty acid, and glucose before, during, and/or at 20, 60, and/or 120 min after the termination of a restraint stress. Furthermore, 12-wk fat-fed animals showed a significant resistance to insulin compared with normally fed controls. There were no differences in negative feedback efficacy in high-fat-fed rats vs. controls. Taken together, these results suggest that dietary fat intake acts as a background form of chronic stress, elevating basal B levels and enhancing HPA responses to stress.

scholarly journals Effect of Pre- and Post-Weaning High-Fat Dietary Manipulation on Intestinal Microflora and Alkaline Phosphatase Activity in Male Rats

2017 ◽  
pp. 677-685 ◽  
Author(s):  
Z. ŠEFČÍKOVÁ ◽  
D. BUJŇÁKOVÁ
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Microbiota ◽  
Alkaline Phosphatase Activity ◽  
Intestinal Microflora ◽  
Male Rats ◽  
Standard Diet ◽  
Fat Intake ◽  
Dietary Manipulation ◽  
High Fat ◽  
The Impact

We investigated the impact of a high-fat (HF) diet during pre- and post-weaning periods on the intestinal microbiota and alkaline phosphatase (AP) activity in male rats. Nutrition from birth was influenced by feeding rat dams with either a standard or HF diet. After weaning male pups nursed by control dams continued on a standard diet (CC) or HF diet (C→HF), while offspring nursed by HF dams continued on HF diet (HF) or standard diet (HF→C). The numbers of Bacteroides/Prevotella (BAC) and Lactobacillus/Enterococcus (LAB) in the gut were determined by FISH technique. HF pups displayed enhanced adiposity and increased AP activity (19 %), as well as higher LAB (P<0.001) and lower numbers of BAC (P<0.001) in the jejunum and colon than controls. In HF→C rats, post-weaning lower fat intake resulted in decreased fat deposition accompanied by reduced AP activity (20 %) compared to HF rats. Composition of the intestinal microbiota in these rats was not influenced. In contrast, in comparison with controls, C→HF rats displayed higher LAB (P<0.001) and lower BAC (P<0.001) together with increased adiposity and AP activity (14 %). These results indicate that consumption of diet with different fat content could modulate gut microbial/functional conditions depending on the period when the nutritional manipulation occurs.

Cats increase fatty acid oxidation when isocalorically fed meat-based diets with increasing fat content

1999 ◽  
Vol 277 (3) ◽  
pp. R878-R886 ◽  
Author(s):  
Tammy Lester ◽  
Gail Czarnecki-Maulden ◽  
Douglas Lewis
Keyword(s):  
Fat Oxidation ◽  
Fat Content ◽  
Acid Oxidation ◽  
Fat Intake ◽  
High Fat ◽  
Short Term ◽  
Body Fat Content ◽  
High Fat Diets ◽  
Maintain Body Weight ◽  
Fat Diets

This study tested the hypothesis that sedentary cats have the ability to adapt to high-fat carnivore diets by increasing fat oxidation. Twenty-four hour indirect calorimetry was used to determine total energy expenditure (TEE) and macronutrient oxidation in six vasectomized male (VAS) and six ovariectomized female (OVX) cats isocalorically fed lower-fat (53% fat, 45% protein) and higher-fat (71% fat, 26% protein) meat-based diets at maintenance for 8 days. Fat oxidation increased linearly with fat intake with a mean slope of 0.91 g fat oxidized/g fat intake ( P < 0.001), with no change in TEE. However, VAS male cats were able to more precisely match fat oxidation with fat intake than OVX female cats ( P < 0.02). Body fat content did not significantly influence fat oxidation. These results demonstrate that cats maintain body weight during short-term isocaloric feeding of a high-fat carnivore-type diet in part by increasing fat oxidation commensurate with increases in fat intake. This ability may be an important mechanism underlying the resistance of cats to obesity, despite habitual consumption of high-fat diets.

Effect of Aerobic Training and High-fat Diet on Enos and Ros in Testicular Tissue of Juvenile Male Rats

2021 ◽  
Vol 20 (3) ◽  
pp. 280-289
Author(s):  
Parisa Norouzzadeh ◽  
◽  
Roghayeh Pouzesh Jadidi ◽  
Keyword(s):  
Aerobic Exercise ◽  
High Fat Diet ◽  
Aerobic Training ◽  
Testicular Tissue ◽  
Normal Diet ◽  
Male Rats ◽  
Adolescent Male ◽  
Male Mice ◽  
High Fat ◽  
Diet Control

Background and Objectives: This study aimed to determine the effect of a course of aerobic exercise with a high-fat diet on eNOS and ROS in testicular tissue of adolescent male rats. Subjects and Methods A total of 40 adolescent male rats (30 days old) were randomized in the following groups: normal diet control, normal diet training, high fat diet control, and high-fat diet training. The high-fat diet rats were under a high-fat regimen (5.817 kcal/g) for 30 days, and then a normal fat diet (3.801 kcal/g) was continued after the 60th day of birth. Aerobic training was conducted for four weeks included three training sessions from the 70th to 98th days of life. Results The results showed that the amount of ROS in the testicular tissue of male mice was higher only in the high-fat diet group. Also, there was no significant difference between the groups regarding eNOS testicular tissue in male mice. Conclusion A high-fat diet increases the production of reactive oxygen species in testicular tissue and is not affected by aerobic exercise. Also, neither exercise nor a high-fat diet had any effect on testicular eNOS. However, due to the limitations of this study and no evidence in this field, further studies are needed on cell phenotype, sperm fate, and identification of pathways involved in the occurrence of oxidative stress and subsequent effects of eNOS activation in testicular tissue in response to exercise and obesity.

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