scholarly journals Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

2012 ◽  
Vol 12 (10) ◽  
pp. 1159-1184 ◽  
Author(s):  
Poyil Pratheeshkumar ◽  
Chakkenchath Sreekala ◽  
Zhuo Zhang ◽  
Amit Budhraja ◽  
Songze Ding ◽  
...  
Keyword(s):  
Natural Products ◽  
Cancer Prevention ◽  
Molecular Targets ◽  
Mechanisms Of Action

Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets.

2016 ◽  
Vol 16 (8) ◽  
pp. 596-604 ◽  
Author(s):  
Daniela Bonofiglio ◽  
Cinzia Giordano ◽  
Francesca De Amicis ◽  
Marilena Lanzino ◽  
Sebastiano Andò
Keyword(s):  
Breast Cancer ◽  
Natural Products ◽  
Molecular Targets ◽  
Mechanisms Of Action

Anticancer Potential of Compounds from the Brazilian Blue Amazon

Planta Medica ◽  
2020 ◽  
Author(s):  
Diego V. Wilke ◽  
Paula C. Jimenez ◽  
Paola C. Branco ◽  
Paula Rezende-Teixeira ◽  
Amaro E. Trindade-Silva ◽  
...  
Keyword(s):  
Natural Products ◽  
Small Molecule ◽  
Marine Natural Products ◽  
Molecular Targets ◽  
Mechanisms Of Action ◽  
Marine Organisms ◽  
Genetic Characteristics ◽  
Species Inventory ◽  
Modest Contribution ◽  
Marine Compounds

Abstract“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of their genes meet some of these other layers. These metabolites produced by terrestrial creatures traditionally and lately added to by those from marine organisms are recognized for their pharmaceutical value, since over 50% of small molecule-based medicines are related to natural products. Nonetheless, Brazil gives a modest contribution to the field of pharmacology and even less when considering marine pharmacology, which still lacks comprehensive in-depth assessments toward the bioactivity of marine compounds so far. Therefore, this review examined the last 40 years of Brazilian natural products research, focusing on molecules that evidenced anticancer potential–which represents ~ 15% of marine natural products isolated from Brazilian species. This review discusses the most promising compounds isolated from sponges, cnidarians, ascidians, and microbes in terms of their molecular targets and mechanisms of action. Wrapping up, the review delivers an outlook on the challenges that stand against developing groundbreaking natural products research in Brazil and on a means of surpassing these matters.

Anti-mycobacterial natural products and mechanisms of action

2021 ◽  
Author(s):  
Jianying Han ◽  
Xueting Liu ◽  
Lixin Zhang ◽  
Ronald J. Quinn ◽  
Yunjiang Feng
Keyword(s):  
Natural Products ◽  
Molecular Targets ◽  
Mechanisms Of Action ◽  
Drug Resistant ◽  
Novel Targets

This review summarises the molecular targets of 53 anti-TB natural products and highlights the compounds with novel targets and activity against drug-resistant TB.

Molecular Targets of Phytochemicals for Skin Inflammation

2018 ◽  
Vol 24 (14) ◽  
pp. 1533-1550 ◽  
Author(s):  
Jong-Eun Kim ◽  
Ki Won Lee
Keyword(s):  
Skin Diseases ◽  
Molecular Targets ◽  
Skin Inflammation ◽  
Mechanisms Of Action ◽  
The Body ◽  
Cellular Damage ◽  
Aesthetic Appearance ◽  
Immune Mediated ◽  
Skin Conditions ◽  
Effects Of Aging

Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left unchecked. Studies have shown that phytochemicals can alter processes involved in skin inflammation and alleviate the effects of aging, cancer, atopic dermatitis, psoriasis, and vitiligo. Direct molecular targets of some phytochemicals have been identified and their precise mechanisms of action investigated. In this review, we summarize recent findings on the effects of phytochemicals on skin inflammation and the mechanisms of action involved.

scholarly journals Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages

2021 ◽  
Author(s):  
Mei-yue Song ◽  
Jia-xin Wang ◽  
You-liang Sun ◽  
Zhi-fa Han ◽  
Yi-tian Zhou ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Therapeutic Strategy ◽  
Molecular Targets ◽  
Mechanisms Of Action ◽  
Inflammasome Activation ◽  
Lung Macrophages ◽  
Nlrp3 Inflammasome Activation ◽  
Function Test ◽  
And Control ◽  
Therapeutic Administration

AbstractSilicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly. Exacerbating this issue, there are currently few drugs reported to effectively treat silicosis. Tetrandrine is the only drug approved for silicosis treatment in China, and despite more than decades of use, its efficacy and mechanisms of action remain largely unknown. Here, in this study, we established silicosis mouse models to investigate the effectiveness of tetrandrine of early and late therapeutic administration. To this end, we used multiple cardiopulmonary function test, as well as markers for inflammation and fibrosis. Moreover, using single cell RNA sequencing and transcriptomics of lung tissue and quantitative microarray analysis of serum from silicosis and control mice, our results provide a novel description of the target pathways for tetrandrine. Specifically, we found that tetrandrine attenuated silicosis by inhibiting both the canonical and non-canonical NLRP3 inflammasome pathways in lung macrophages. Taken together, our work showed that tetrandrine yielded promising results against silicosis-associated inflammation and fibrosis and further lied the groundwork for understanding its molecular targets. Our results also facilitated the wider adoption and development of tetrandirne, potentially accelerating a globally accepted therapeutic strategy for silicosis.

Natural products for cancer prevention: a global perspective

2003 ◽  
Vol 99 (1) ◽  
pp. 1-13 ◽  
Author(s):  
L. Reddy ◽  
B. Odhav ◽  
K.D. Bhoola
Keyword(s):  
Natural Products ◽  
Cancer Prevention ◽  
Global Perspective

scholarly journals Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Omolola R. Oyenihi ◽  
Ayodeji B. Oyenihi ◽  
Anne A. Adeyanju ◽  
Oluwafemi O. Oguntibeju
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Utility ◽  
Therapeutic Agent ◽  
Molecular Targets ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Antidiabetic Drug ◽  
Near Future ◽  
Antidiabetic Effects ◽  
The Way

Despite recent advances in the understanding and management ofdiabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessitated the search for novel therapeutic agents. Due to the multipathogenicity ofdiabetes mellitus,plant-derived compounds with proven multiple pharmacological actions have been postulated to “hold the key” in the search for an affordable, efficacious, and safer therapeutic agent in the treatment of the disease and associated complications. Resveratrol, a phytoalexin present in few plant species, has demonstrated beneficial antidiabetic effects in animals and humans through diverse mechanisms and multiple molecular targets. However, despite the enthusiasm and widespread successes achieved with the use of resveratrol in animal models ofdiabetes mellitus, there are extremely limited clinical data to confirm the antidiabetic qualities of resveratrol. This review presents an update on the mechanisms of action and protection of resveratrol indiabetes mellitus, highlights challenges in its clinical utility, and suggests the way forward in translating the promising preclinical data to a possible antidiabetic drug in the near future.

Actin-targeting natural products: structures, properties and mechanisms of action

2006 ◽  
Vol 63 (18) ◽  
pp. 2119-2134 ◽  
Author(s):  
J. S. Allingham ◽  
V. A. Klenchin ◽  
I. Rayment
Keyword(s):  
Natural Products ◽  
Mechanisms Of Action

Natural products show diverse mechanisms of action against Clostridium difficile

2018 ◽  
Vol 126 (2) ◽  
pp. 468-479 ◽  
Author(s):  
N. Roshan ◽  
T.V. Riley ◽  
D.R. Knight ◽  
J.H. Steer ◽  
K.A. Hammer
Keyword(s):  
Natural Products ◽  
Clostridium Difficile ◽  
Mechanisms Of Action

scholarly journals Natural products with therapeutic potential in melanoma metastasis

2015 ◽  
Vol 32 (8) ◽  
pp. 1170-1182 ◽  
Author(s):  
A. AlQathama ◽  
J. M. Prieto
Keyword(s):  
Natural Products ◽  
Cancer Treatment ◽  
Therapeutic Potential ◽  
Melanoma Cells ◽  
Mechanisms Of Action ◽  
Melanoma Metastasis ◽  
Pharmacological Effects ◽  
Cytotoxic Compounds

Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. We here systematically and critically survey more than 30 natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and chart the mechanisms of action for this underexploited property.

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