Modeling Anti-HIV Compounds: The Role of Analogue-Based Approaches

2012 ◽  
Vol 8 (3) ◽  
pp. 224-248 ◽  
Author(s):  
Hemant Kumar Srivastava ◽  
Mohammed H. Bohari ◽  
G. Narahari Sastry
Keyword(s):  
Anti Hiv

The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches

2013 ◽  
Vol 41 (5) ◽  
pp. 1170-1176 ◽  
Author(s):  
Brian W. Woodrum ◽  
Jason D. Maxwell ◽  
Ashini Bolia ◽  
S. Banu Ozkan ◽  
Giovanna Ghirlanda
Keyword(s):  
Viral Entry ◽  
High Specificity ◽  
Integrated Approach ◽  
Protein Gp120 ◽  
Computational Work ◽  
Gp120 Glycoprotein ◽  
Anti Hiv Agents ◽  
Anti Hiv ◽  
Envelope Protein Gp120

CVN (cyanovirin-N), a small lectin isolated from cyanobacteria, exemplifies a novel class of anti-HIV agents that act by binding to the highly glycosylated envelope protein gp120 (glycoprotein 120), resulting in inhibition of the crucial viral entry step. In the present review, we summarize recent work in our laboratory and others towards determining the crucial role of multivalency in the antiviral activity, and we discuss features that contribute to the high specificity and affinity for the glycan ligand observed in CVN. An integrated approach that encompasses structural determination, mutagenesis analysis and computational work holds particular promise to clarify aspects of the interactions between CVN and glycans.

scholarly journals Crystal Forms of Anti-HIV Drugs: Role of Recrystallization

10.5772/33777 ◽  
2012 ◽  
Author(s):  
Renu Chadha ◽  
Poonam Arora ◽  
Anupam Saini ◽  
Swati Bhandari
Keyword(s):  
Crystal Forms ◽  
Hiv Drugs ◽  
Anti Hiv

scholarly journals Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity

2020 ◽  
Vol 11 ◽  
Author(s):  
Wilfried Posch ◽  
Marta Bermejo-Jambrina ◽  
Cornelia Lass-Flörl ◽  
Doris Wilflingseder
Keyword(s):  
Complement Receptors ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals The critical role of human transcriptional repressor CTCF mRNA up-regulation in the induction of anti-HIV-1 responses in CD4+ T cells

2008 ◽  
Vol 117 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Yuchang Li ◽  
Guanhua Li ◽  
Anna Ivanova ◽  
Sagiv Aaron ◽  
Malgorzata Simm
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Critical Role ◽  
Transcriptional Repressor ◽  
Anti Hiv ◽  
Hiv 1

Role of screening for anti-HIV antibodies in patients treated in large multidisciplinary hospitals

2019 ◽  
Vol 17 (2) ◽  
pp. 5-11 ◽  
Author(s):  
E.N. Kudryavtseva ◽  
◽  
T.A. Semenenko ◽  
M.A. Godkov ◽  
O.N. Ershova ◽  
...  
Keyword(s):  
Hiv Antibodies ◽  
Anti Hiv

REVIEW OF HIV MODELS: THE ROLE OF THE NATURAL IMMUNE RESPONSE AND IMPLICATIONS FOR TREATMENT

2004 ◽  
Vol 12 (02) ◽  
pp. 123-135 ◽  
Author(s):  
REBECCA V. CULSHAW
Keyword(s):  
Immune Response ◽  
Optimal Treatment ◽  
Minimal Cost ◽  
Treatment Scenario ◽  
Forcing Function ◽  
Drug Regimens ◽  
Differential Equations Models ◽  
Anti Hiv ◽  
Hiv 1

We present a review and comparison of several recent differential equations models of treatment of HIV-1 infection. We seek to clarify the role of the natural anti-HIV immune response and determine its effect upon optimal treatment schemes. In this paper, we consider systems in which treatment is expressed as a forcing function, as well as those in which we determine optimal treatment via control theoretic techniques. The primary goal of this study is to compare treatment schemes for systems in which a natural nonconstant immune response of the patient is considered explicitly with those that consider implicitly a constant non-specific immune response. We find that when the natural immune response can be boosted sufficiently, drug levels may not need to be as high as previously supposed. This implies that a treatment scenario in which intervals of drug treatment are alternated with some form of immune-boosting therapy may be highly beneficial in terms of reducing toxicity to the patient. Additionally, in developing countries where HIV infection is widespread and sufficient funds are not available to supply rigourous drug regimens, the implications of these models are profound, as they suggest methods of treating HIV at a minimal cost.

scholarly journals The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Joseph T. Ortega ◽  
Alirica I. Suárez ◽  
Maria L. Serrano ◽  
Jani Baptista ◽  
Flor H. Pujol ◽  
...  
Keyword(s):  
Anti Hiv ◽  
Hiv 1

Role of the M2 Subunit of Ribonucleotide Reductase in Regulation by Hydroxyurea of the Activity of the Anti-HIV-1 Agent 2′,3′-Dideoxyinosine

1998 ◽  
Vol 56 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Wen-Yi Gao ◽  
Bing-Sen Zhou ◽  
David G Johns ◽  
Hiroaki Mitsuya ◽  
Yun Yen
Keyword(s):  
Ribonucleotide Reductase ◽  
Anti Hiv ◽  
Hiv 1

Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents

2013 ◽  
Vol 439 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Yumi Hashiguchi ◽  
Akinobu Hamada ◽  
Takashi Shinohara ◽  
Kiyoto Tsuchiya ◽  
Hirofumi Jono ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Intestinal Cells ◽  
P Glycoprotein ◽  
Anti Hiv Agents ◽  
Anti Hiv ◽  
Human Intestinal Cells

A 4‘-C-Ethynyl-2‘,3‘-Dideoxynucleoside Analogue Highlights the Role of the 3‘-OH in Anti-HIV Active 4‘-C-Ethynyl-2‘-deoxy Nucleosides

2004 ◽  
Vol 47 (21) ◽  
pp. 5041-5048 ◽  
Author(s):  
Maqbool A. Siddiqui ◽  
Stephen H. Hughes ◽  
Paul L. Boyer ◽  
Hiroaki Mitsuya ◽  
Que N. Van ◽  
...  
Keyword(s):  
Anti Hiv
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