Transdermal Drug Delivery of Labetolol Hydrochloride: System Development, In Vitro; Ex Vivo and In Vivo Characterization

2005 ◽  
Vol 2 (2) ◽  
pp. 125-131 ◽  
Author(s):  
M. Aqil ◽  
Saqib Zafar ◽  
Asgar Ali ◽  
Shoaib Ahmad
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Ex Vivo ◽  
System Development ◽  
Development In Vitro ◽  
In Vivo Characterization

Self-nanoemulsifying drug delivery system of docosahexanoic acid: development, in vitro, in vivo characterization

2015 ◽  
Vol 42 (7) ◽  
pp. 1032-1041 ◽  
Author(s):  
Ritika Puri ◽  
Mohit Mahajan ◽  
Nikhil Shri Sahajpal ◽  
Harjeet Singh ◽  
Harmanpreet Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Docosahexanoic Acid ◽  
Development In Vitro ◽  
In Vivo Characterization

scholarly journals Transdermal Drug Delivery Systems of a Beta Blocker: Design, In Vitro, and In Vivo Characterization

Drug Delivery ◽  
2004 ◽  
Vol 11 (1) ◽  
pp. 27-31 ◽  
Author(s):  
M. Aqil ◽  
Yasmin Sultana ◽  
Asgar Ali ◽  
Kiran Dubey ◽  
A. K. Najmi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Beta Blocker ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems ◽  
In Vivo Characterization

In Vitro, Ex Vivo, and In Vivo Evaluation of a Dual pH/Redox Responsive Nanoliposomal Sludge for Transdermal Drug Delivery

2018 ◽  
Vol 107 (4) ◽  
pp. 1028-1036 ◽  
Author(s):  
Simphiwe Mavuso ◽  
Thashree Marimuthu ◽  
Pradeep Kumar ◽  
Pierre P.D. Kondiah ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Ex Vivo ◽  
In Vivo Evaluation ◽  
Redox Responsive

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

scholarly journals Development of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, and In-Vivo Evaluation

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2920
Author(s):  
Ameeduzzafar Zafar ◽  
Syed Sarim Imam ◽  
Nabil K. Alruwaili ◽  
Omar Awad Alsaidan ◽  
Mohammed H. Elkomy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Ex Vivo ◽  
In Vitro Release ◽  
System Optimization ◽  
Globule Size

Hypertension is a cardiovascular disease that needs long-term medication. Oral delivery is the most common route for the administration of drugs. The present research is to develop piperine self-nanoemulsifying drug delivery system (PE-SNEDDS) using glyceryl monolinoleate (GML), poloxamer 188, and transcutol HP as oil, surfactant, and co-surfactant, respectively. The formulation was optimized by three-factor, three-level Box-Behnken design. PE-SNEDDs were characterized for globule size, emulsification time, stability, in-vitro release, and ex-vivo intestinal permeation study. The optimized PE-SNEDDS (OF3) showed the globule size of 70.34 ± 3.27 nm, percentage transmittance of 99.02 ± 2.02%, and emulsification time of 53 ± 2 s Finally, the formulation OF3 was transformed into solid PE-SNEDDS (S-PE-SNEDDS) using avicel PH-101 as adsorbent. The reconstituted SOF3 showed a globule size of 73.56 ± 3.54 nm, PDI of 0.35 ± 0.03, and zeta potential of −28.12 ± 2.54 mV. SEM image exhibited the PE-SNEDDS completely adsorbed on avicel. Thermal analysis showed the drug was solubilized in oil, surfactant, and co-surfactant. S-PE-SNEDDS formulation showed a more significant (p < 0.05) release (97.87 ± 4.89% in 1 h) than pure PE (27.87 ± 2.65% in 1 h). It also exhibited better antimicrobial activity against S. aureus and P. aeruginosa and antioxidant activity as compared to PE dispersion. The in vivo activity in rats exhibited better (p < 0.05) antihypertensive activity as well as 4.92-fold higher relative bioavailability than pure PE dispersion. Finally, from the results it can be concluded that S-PE-SNEDDS might be a better approach for the oral delivery to improve the absorption and therapeutic activity.

scholarly journals GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS

2017 ◽  
Vol 4 (2) ◽  
pp. 10 ◽  
Author(s):  
Harshil P. Shah ◽  
Shailesh T. Prajapati ◽  
C. N. Patel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Route ◽  
Delivery Systems ◽  
Present Review ◽  
Gastric Residence Time ◽  
In Vivo Characterization ◽  
Absorption Window

Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

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