The Effects of Drugs Used in Anaesthesia on Platelet Membrane Receptors and on Platelet Function

2002 ◽  
Vol 3 (3) ◽  
Author(s):  
Sibylle A. Kozek-Langenecker
Keyword(s):  
Platelet Function ◽  
Platelet Membrane ◽  
Membrane Receptors

Platelet–adenovirus vs. inert particles interaction: Effect on aggregation and the role of platelet membrane receptors

Platelets ◽  
2012 ◽  
Vol 24 (5) ◽  
pp. 383-391 ◽  
Author(s):  
Elena Gupalo ◽  
Cynthia Kuk ◽  
Mohammad Qadura ◽  
Liudmila Buriachkovskaia ◽  
Maha Othman
Keyword(s):  
Interaction Effect ◽  
Platelet Membrane ◽  
Membrane Receptors ◽  
Inert Particles

scholarly journals Platelet Function in Hyperbetalipoproteinemia

1977 ◽  
Author(s):  
Robert W. Colman
Keyword(s):  
Platelet Function ◽  
Platelet Membrane ◽  
In Vitro Tests ◽  
Pharmacologic Agent ◽  
Platelet Factor ◽  
Functional Changes ◽  
Platelet Membranes ◽  
Increased Risk ◽  
Phospholipid Ratio

Individuals with familial hyperbetalipoproteinemia are at increased risk of premature atherosclerosis and thrombosis. Although there is controversy whether platelet survival is shortened or normal in this disease, several in vitro tests of platelet function after stimulation with ADP including electrophoretic migration, platelet factor 3, aggregation response and release of nucleotides have been found to be increased. These functional changes are accompanied by an increase of cholesterol to phospholipid ratio in the platelet membrane. Clofibrate and halofenate reverse some of these abnormalities in vitro and the former drug, when administered for 6 weeks to patients with type IIa hyperlipoproteinemia decreases platelet sensitivity to ADP and epinephrine. The platelet hypersensitivity to aggregating agents can be reproduced in vitro by increasing the cholesterol to phospholipid rather in normal platelets. These artificially hypersensitive platelets can be returned to normal by halofenate in vitro. Incorporation of cholesterol into platelet membranes increases the basal level of the membrane associated enzyme adenylate cyclase. However, the enzyme no longer responds to stimulation by prostaglandin E1, and this is associated with relative resistance of the platelet to inhibition by this pharmacologic agent. These functional alterations produced by cholesterol enrichment of platelet membranes occur in parallel with an increase in platelet membrane microviscosity suggesting that the more rigid membrane can alter the behavior cf membrane associated enzymes and receptors.

Correlation between the P1A2 Platelet Membrane GpIIIa Allele and Platelet Function for Subjects with and Without Coronary Artery Disease

1999 ◽  
Vol 96 (s40) ◽  
pp. 3P-3P
Author(s):  
G Bashir ◽  
A Bakhai ◽  
HE Gendi ◽  
M Sumiya ◽  
NA Flores ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Platelet Function ◽  
Platelet Membrane ◽  
Artery Disease

scholarly journals Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia

2016 ◽  
Vol 14 (3) ◽  
pp. 2052-2060 ◽  
Author(s):  
Wen-Jun Liu ◽  
Jing Bai ◽  
Qu-Lian Guo ◽  
Zhe Huang ◽  
Hong Yang ◽  
...  
Keyword(s):  
Platelet Function ◽  
Immune Thrombocytopenia ◽  
Platelet Membrane ◽  
Membrane Glycoproteins ◽  
Primary Immune Thrombocytopenia

scholarly journals Platelet Membrane Receptor Proteolysis: Implications for Platelet Function

2021 ◽  
Vol 7 ◽  
Author(s):  
Jiayu Wu ◽  
Johan W. M. Heemskerk ◽  
Constance C. F. M. J. Baaten
Keyword(s):  
Platelet Function ◽  
Platelet Membrane ◽  
Comprehensive Overview ◽  
Activated Platelets ◽  
Platelet Membrane Receptor ◽  
Proteolytic Activities ◽  
Signaling Receptors ◽  
Different Origins ◽  
Cytosolic Receptor ◽  
Platelet Functions

The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. We provide a comprehensive overview of the proteases acting on the platelet membrane. We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. The review focuses on coagulation-related proteases, plasmin, matrix metalloproteinases, ADAM(TS) isoforms, cathepsins, caspases, and calpains. We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations.

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