Apoptosis: Potential Therapeutic Targets for New Drug Discovery

2007 ◽  
Vol 14 (22) ◽  
pp. 2369-2379 ◽  
Author(s):  
Snehasis Jana ◽  
Jyoti Paliwal
Keyword(s):  
Drug Discovery ◽  
Therapeutic Targets ◽  
New Drug

Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances

2019 ◽  
Vol 22 (8) ◽  
pp. 509-520
Author(s):  
Cauê B. Scarim ◽  
Chung M. Chin
Keyword(s):  
Drug Discovery ◽  
Chagas Disease ◽  
Drug Candidates ◽  
Lead Compounds ◽  
New Drug ◽  
Compound Libraries ◽  
Screening Assays ◽  
Cruzi Infection

Background: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years, focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease.

scholarly journals ONRLDB—manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery

Database ◽  
2015 ◽  
Vol 2015 ◽  
pp. bav112 ◽  
Author(s):  
Ravikanth Nanduri ◽  
Isha Bhutani ◽  
Arun Kumar Somavarapu ◽  
Sahil Mahajan ◽  
Raman Parkesh ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Nuclear Receptors ◽  
Orphan Nuclear Receptors ◽  
New Drug

HTRF Applications in New Drug Discovery

2013 ◽  
Vol 33 (13) ◽  
pp. 21-21
Author(s):  
John Sterling
Keyword(s):  
Drug Discovery ◽  
New Drug

scholarly journals Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders

2018 ◽  
Vol 12 ◽  
Author(s):  
Chanshuai Han ◽  
Mathilde Chaineau ◽  
Carol X.-Q. Chen ◽  
Lenore K. Beitel ◽  
Thomas M. Durcan
Keyword(s):  
Stem Cells ◽  
Drug Discovery ◽  
Neurodegenerative Disorders ◽  
Open Science ◽  
New Drug

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

2018 ◽  
Vol 150 ◽  
pp. 525-545 ◽  
Author(s):  
André Campaniço ◽  
Rui Moreira ◽  
Francisca Lopes
Keyword(s):  
Drug Discovery ◽  
Drug Targets ◽  
New Drug ◽  
Antimycobacterial Agents

Approaches to New Drug Discovery

2000 ◽  
pp. 233-256
Author(s):  
Lawrence M. Kauvar
Keyword(s):  
Drug Discovery ◽  
New Drug

Meeting the challenge of cardiovascular new drug discovery

1984 ◽  
Vol 4 (3) ◽  
pp. 237-240 ◽  
Author(s):  
Ronald D. Smith
Keyword(s):  
Drug Discovery ◽  
New Drug
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