The Application of Photofrin II® as a Sensitizing Agent for Ionizing Radiation-A New Approach in Tumor Therapy?

2005 ◽  
Vol 12 (10) ◽  
pp. 1209-1215 ◽  
Author(s):  
M. Schaffer ◽  
B. Ertl-Wagner ◽  
P. Schaffer ◽  
U. Kulka ◽  
G. Jori ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tumor Therapy ◽  
New Approach ◽  
Photofrin Ii

scholarly journals Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation

Redox Biology ◽  
2019 ◽  
Vol 24 ◽  
pp. 101169 ◽  
Author(s):  
Aaron Wilson ◽  
Vijay Menon ◽  
Zubair Khan ◽  
Asim Alam ◽  
Larisa Litovchick ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ionizing Radiation ◽  
Parp Inhibitor ◽  
Nitric Oxide Donor ◽  
New Approach ◽  
Inhibitor Combination

scholarly journals The Metabolism Symbiosis Between Pancreatic Cancer and Tumor Microenvironment

2021 ◽  
Vol 11 ◽  
Author(s):  
Ying Li ◽  
Ju Zhang ◽  
Jie Xu ◽  
Shanglong Liu
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Cells ◽  
Tumor Therapy ◽  
Tumor Development ◽  
Metabolic Reprogramming ◽  
Metabolic Adaptation ◽  
Metabolic Pattern ◽  
New Approach ◽  
Complex Interactions ◽  
Selective Targeting

Complex interactions occur between tumor cells and the tumor microenvironment. Studies have focused on the mechanism of metabolic symbiosis between tumors and the tumor microenvironment. During tumor development, the metabolic pattern undergoes significant changes, and the optimal metabolic mode of the tumor is selected on the basis of its individual environment. Tumor cells can adapt to a specific microenvironment through metabolic adjustment to achieve compatibility. In this study, the effects of tumor glucose metabolism, lipid metabolism, and amino acid metabolism on the tumor microenvironment and related mechanisms were reviewed. Selective targeting of tumor cell metabolic reprogramming is an attractive direction for tumor therapy. Understanding the mechanism of tumor metabolic adaptation and determining the metabolism symbiosis mechanism between tumor cells and the surrounding microenvironment may provide a new approach for treatment, which is of great significance for accelerating the development of targeted tumor metabolic drugs and administering individualized tumor metabolic therapy.

Bacterial Delivery of siRNAs: A New Approach to Solid Tumor Therapy

2008 ◽  
pp. 1-27 ◽  
Author(s):  
De-Qi Xu ◽  
Ling Zhang ◽  
Dennis J Kopecko ◽  
Lifang Gao ◽  
Yueting Shao ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Tumor Therapy ◽  
New Approach ◽  
Solid Tumor Therapy

scholarly journals Scintigraphic imaging of focal hypoxic tissue: development and clinical applications of 123I-IAZA

2002 ◽  
Vol 45 (spe) ◽  
pp. 69-81 ◽  
Author(s):  
Leonard I. Wiebe ◽  
Alexander J. B. McEwan
Keyword(s):  
Ionizing Radiation ◽  
Planning Process ◽  
Covalent Binding ◽  
Tumor Therapy ◽  
Prognostic Indicator ◽  
Clinical Applications ◽  
Radiotherapy Planning ◽  
Current Status ◽  
Planar Imaging ◽  
Solid Tumor Therapy

Affected tissues in a number of diseases, including cancer, stroke, cardiac infarction and diabetes, develop focal tissue hypoxia during their progression. The presence of hypoxic tissue may make the disease refractory to therapy, as in the case of solid tumor therapy using low LET ionizing radiation. In other pathologies, the detection of viable but hypoxic tissues may serve as a prodromal indicator of developing disease (e.g. diabetes),or as a prognostic indicator for management of the disease (e.g. stroke). Over the past two decades, a number of hypoxia radioimaging agents have been developed and tested clinically. Of these, 18F-Fmiso and 123I-IAZA are the most widely used radiotracers for PET and SPECT/planar imaging, respectively. IAZA and Fmiso are a 2-nitroimidazoles that chemically bind to subcellular components of viable hypoxic tissues. They sensitize hypoxic tumour to the killing effects of ionizing radiation via mechanisms that mimic the radiosensitizing effects of oxygen, and are therefore called oxygen mimetics. The oxygen mimetic effect is attributable in large part to the covalent binding of reductively-activated nitroimidazole intermediates to critical cellular macromolecules. Nitroimidazoles labelled with gamma-emitting radionuclides (e.g. 18F-Fmiso and 123I-IAZA) have been used as scintigraphic markers of tumour hypoxia, based on the need to identify radioresistant hypoxic tumour cells as part of the radiotherapy planning process. Broader interest in non-invasive, imaging-based identification of focal hypoxia in a number of diseases has extended hypoxia studies to include peripheral vascular disease associated with diabetes, rheumatoid arthritis, stroke, myocardial ischaemia, brain trauma and oxidative stress. In this review, the current status of hypoxia-selective studies with 123I-IAZA , an experimental diagnostic radiopharmaceutical, is reviewed with respect to its pre-clinical development and clinical applications.

scholarly journals Tumor stem cells: A new approach for tumor therapy (Review)

2012 ◽  
Vol 4 (2) ◽  
pp. 187-193 ◽  
Author(s):  
MIN MENG ◽  
XIN-HAN ZHAO ◽  
QIAN NING ◽  
LEI HOU ◽  
GUO-HONG XIN ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Therapy ◽  
Tumor Stem Cells ◽  
New Approach

NMR relaxation enhancement in gels polymerized and cross-linked by ionizing radiation: A new approach to 3D dosimetry by MRI

1993 ◽  
Vol 11 (2) ◽  
pp. 253-258 ◽  
Author(s):  
Marek J. Maryanski ◽  
John C. Gore ◽  
Richard P. Kennan ◽  
Robert J. Schulz
Keyword(s):  
Ionizing Radiation ◽  
Nmr Relaxation ◽  
New Approach ◽  
3D Dosimetry

A new approach for discriminative measurements of different components of external ionizing radiation

2017 ◽  
Vol 173 ◽  
pp. 2-5 ◽  
Author(s):  
Zhen Yang ◽  
Bo Chen ◽  
Weihai Zhuo ◽  
Chao Zhao ◽  
Weiyuan Zhang
Keyword(s):  
Ionizing Radiation ◽  
New Approach
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