scholarly journals Strategic Environmental Research and Development Project FY 1994: Assessing national remote sensing technologies for use in US Department of Energy Environmental Restoration Activities, Oak Ridge Solid Waste Storage Area 4 case study

10.2172/71646 ◽  
1995 ◽  
Author(s):  
A.L. King ◽  
J.L. Smyre ◽  
T.K. Evers
Keyword(s):  
Remote Sensing ◽  
Research And Development ◽  
Development Project ◽  
Department Of Energy ◽  
Environmental Research ◽  
Environmental Restoration ◽  
Oak Ridge ◽  
Waste Storage ◽  
Storage Area

scholarly journals Fifteen years of the Protein Crystallography Station: the coming of age of macromolecular neutron crystallography

IUCrJ ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. 72-86 ◽  
Author(s):  
Julian C.-H. Chen ◽  
Clifford J. Unkefer
Keyword(s):  
Coming Of Age ◽  
National Laboratory ◽  
Protein Crystallography ◽  
Enzyme Reaction ◽  
Department Of Energy ◽  
Environmental Research ◽  
Macromolecular Crystallography ◽  
Oak Ridge ◽  
The 1960S ◽  
Neutron Crystallography

The Protein Crystallography Station (PCS), located at the Los Alamos Neutron Scattering Center (LANSCE), was the first macromolecular crystallography beamline to be built at a spallation neutron source. Following testing and commissioning, the PCS user program was funded by the Biology and Environmental Research program of the Department of Energy Office of Science (DOE-OBER) for 13 years (2002–2014). The PCS remained the only dedicated macromolecular neutron crystallography station in North America until the construction and commissioning of the MaNDi and IMAGINE instruments at Oak Ridge National Laboratory, which started in 2012. The instrument produced a number of research and technical outcomes that have contributed to the field, clearly demonstrating the power of neutron crystallography in helping scientists to understand enzyme reaction mechanisms, hydrogen bonding and visualization of H-atom positions, which are critical to nearly all chemical reactions. During this period, neutron crystallography became a technique that increasingly gained traction, and became more integrated into macromolecular crystallography through software developments led by investigators at the PCS. This review highlights the contributions of the PCS to macromolecular neutron crystallography, and gives an overview of the history of neutron crystallography and the development of macromolecular neutron crystallography from the 1960s to the 1990s and onwards through the 2000s.

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