scholarly journals Tritium waste control: April--June 1978. [Catalytic exchange detritiation; liquid waste decontamination; fixation in polymer impregnated concrete; management of high specific activity tritiated wastes]

1978 ◽  
Author(s):  
Keyword(s):  
Specific Activity ◽  
Liquid Waste ◽  
High Specific Activity ◽  
Catalytic Exchange

Deuterium-exchange Reactions with Substituted Aromatics. IV. The Poisoning Effect of Molecules Containing Nitrogen, Sulphur, or Arsenic

1963 ◽  
Vol 16 (4) ◽  
pp. 549 ◽  
Author(s):  
RA Ashby ◽  
JL Garnett
Keyword(s):  
Heavy Water ◽  
Aromatic Amines ◽  
Adsorption Mechanism ◽  
Specific Activity ◽  
High Specific Activity ◽  
Side Reactions ◽  
Exchange Reactions ◽  
Poisoning Effect ◽  
A Charge ◽  
Catalytic Exchange

The catalytic exchange properties of a number of organic compounds containing nitrogen, sulphur, or arsenic have been studied in the presence of benzene and heavy water. The results confirm a charge-transfer-no-bond adsorption mechanism previously proposed for the deuteration of aromatic polycyclic hydrocarbons. For aromatic nitrogen compounds an increase in ionization potential of substrate leads to an increase in deuterium incorporation and a decrease in catalyst poisoning. Some aromatic amines deuterate faster than expected by theory and this is attributed to rapid exchange of the amino hydrogens in heavy water with a consequential increase in D-H ratio at the catalyst; surface. Sulphur and arsenic, even in their saturated valency states, extensively poison benzene exchange as does triethylamine. p-Benzoquinone, 2,6-dichloroquinone, and NN-dimethyl benzylamine exhibit catalytic side reactions which poison benzene exchange. With tritium oxide, the technique is suitable for the synthesis of tritiated aromatic amines and heterocycles to high specific activity.

Effects of Heparin Oligosaccharides with High Affinity for Antithrombin III in Experimental Venous Thrombosis

1982 ◽  
Vol 47 (03) ◽  
pp. 244-248 ◽  
Author(s):  
D P Thomas ◽  
Rosemary E Merton ◽  
T W Barrowcliffe ◽  
L Thunberg ◽  
U Lindahl
Keyword(s):  
Antithrombin Iii ◽  
Specific Activity ◽  
High Specific Activity ◽  
Factor Xa ◽  
Blood Levels ◽  
Thrombin Time ◽  
High Affinity ◽  
Very High

SummaryThe in vitro and in vivo characteristics of two oligosaccharide heparin fragments have been compared to those of unfractionated mucosal heparin. A decasaccharide fragment had essentially no activity by APTT or calcium thrombin time assays in vitro, but possessed very high specific activity by anti-Factor Xa assays. When injected into rabbits at doses of up to 80 ¼g/kg, this fragment was relatively ineffective in impairing stasis thrombosis despite producing high blood levels by anti-Xa assays. A 16-18 monosaccharide fragment had even higher specific activity (almost 2000 iu/mg) by chromogenic substrate anti-Xa assay, with minimal activity by APTT. When injected in vivo, this fragment gave low blood levels by APTT, very high anti-Xa levels, and was more effective in preventing thrombosis than the decasaccharide fragment. However, in comparison with unfractionated heparin, the 16-18 monosaccharide fragment was only partially effective in preventing thrombosis, despite producing much higher blood levels by anti-Xa assays.It is concluded that the high-affinity binding of a heparin fragment to antithrombin III does not by itself impair venous thrombogenesis, and that the anti-Factor Xa activity of heparin is only a partial expression of its therapeutic potential.

Autoprothrombin C Activity from Prothrombin with Snake Venom or Trypsin

1962 ◽  
Vol 08 (03) ◽  
pp. 425-433 ◽  
Author(s):  
Ewa Marciniak ◽  
Edmond R Cole ◽  
Walter H Seegers
Keyword(s):  
Snake Venom ◽  
Thrombolytic Agent ◽  
Sodium Citrate ◽  
Specific Activity ◽  
High Specific Activity ◽  
Citrate Solution ◽  
Clotting Factors ◽  
Activation Products ◽  
Russell’S Viper ◽  
Autoprothrombin C

SummarySuitable conditions were found for the generation of autoprothrombin C from purified prothrombin with the use of Russell’s viper venom or trypsin. DEAE chromatographed prothrombin is structurally altered and has never been found to yield autoprothrombin C and also did not yield it when Russell’s viper venom or trypsin were used. Autoprothrombin C is derived from prothrombin with tissue extract thromboplastin, but not in large amounts with the intrinsic clotting factors. With the latter thrombin and autoprothrombin III are the chief activation products. Autoprothrombin III concentrates were prepared from serum and upon activation with 25% sodium citrate solution or with Russell’s viper venom large amounts of autoprothrombin C were obtained, and this was of high specific activity. Theoretically trypsin is not a thrombolytic agent, but on the contrary should lead to intravascular clotting.

In-Canal Assay of High Specific Activity 60Co at the Advanced Test Reactor

2021 ◽  
pp. 1-7
Author(s):  
Michael A. Reichenberger ◽  
Jagoda M. Urban-Klaehn ◽  
Jason V. Brookman ◽  
Joshua L. Peterson-Droogh ◽  
Jorge Navarro ◽  
...  
Keyword(s):  
Specific Activity ◽  
High Specific Activity ◽  
Test Reactor

scholarly journals High Specific Activity Labeling of Insulin with 131I

1964 ◽  
Vol 239 (11) ◽  
pp. 3743-3748 ◽  
Author(s):  
Joseph L. Izzo ◽  
William F. Bale ◽  
Mary Jane Izzo ◽  
Angela Roncone
Keyword(s):  
Specific Activity ◽  
High Specific Activity

[125I]Iberiotoxin-D19Y/Y36F, the First Selective, High Specific Activity Radioligand for High-Conductance Calcium-Activated Potassium Channels

Biochemistry ◽  
1997 ◽  
Vol 36 (7) ◽  
pp. 1943-1952 ◽  
Author(s):  
Alexandra Koschak ◽  
Robert O. Koch ◽  
Jessica Liu ◽  
Gregory J. Kaczorowski ◽  
Peter H. Reinhart ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Specific Activity ◽  
High Specific Activity ◽  
Calcium Activated Potassium Channels ◽  
High Conductance
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