scholarly journals Establishment of a corner turning test capability

1978 ◽  
Author(s):  
R.W. Ashcraft ◽  
G.T. West
Keyword(s):  
Corner Turning ◽  
Turning Test

Minocycline Promotes Functional Recovery in Ischemic Stroke by Modulating Microglia Polarization Through STAT1/STAT6 Pathways

2021 ◽  
Author(s):  
Yunnan Lu ◽  
Mingming Zhou ◽  
Yun Li ◽  
Yan Li ◽  
Ye Hua ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Recovery ◽  
Neuronal Injury ◽  
Reactive Gliosis ◽  
Rotarod Test ◽  
M2 Microglia ◽  
Microglia Polarization ◽  
M1 Phenotype ◽  
Corner Turning ◽  
Turning Test

Abstract BackgroundIncreasing evidence suggests that microglia experience two distinct phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a neuroprotective M2 phenotype. Promoting the phenotype shift of M1 microglia to M2 microglia is thought to improve functional recovery after AIS. Minocycline, a tetracycline antibiotic, can improve functional recovery after cerebral ischemia in pre-clinical and clinical research. However, the role and mechanisms of minocycline in microglia polarization is unclear.MethodsUsing the transient middle cerebral artery occlusion - reperfusion (MCAO/R) model, we treated mice with saline or different minocycline concentration (10, 25, or 50 mg/kg, i.p., daily for 2 wk) at 24 h after reperfusion. Neurobehavioral evaluation, rotarod test, and corner turning test were carried out on day 14 after reperfusion. Then, neuronal injury, reactive gliosis, and microglia polarization were performed on day 7 following MCAO/R. Finally, we treated primary microglial cultures with LPS (Lipopolysaccharide; 100 ng/mL) plus IFN-γ (20 ng/mL) 24 h to induce M1 phenotype and observed the effects of minocycline on the M1/M2-related mRNAs and the STAT1/STAT6 pathway.ResultsWe found that a 14-day treatment with minocycline increased the survival rate and promoted functional outcomes evaluated with neurobehavioral evaluation, rotarod test, and corner turning test. Meanwhile, minocycline reduced the brain infarct volume, alleviated neuronal injury, and suppressed reactive gliosis on day 7 following MCAO/R. Moreover, we observed an additive effect of minocycline on microglia polarization to the M1 and M2 phenotypes in vivo and in vitro. In the primary microglia, we further found that minocycline prevented neurons from OGD/R-induced cell death in neuron-microglia co-cultures via regulating M1/M2 microglia polarization through the STAT1/STAT6 pathway. ConclusionMinocycline promoted microglial M2 polarization and inhibited M1 polarization, leading to neuronal survival and neurological functional recovery. The findings deepen our understanding of the mechanisms underlying minocycline-mediated neuroprotection in AIS.

scholarly journals Dynamic three-dimensional observation of corner turning in LX-17 with flash x-rays

2020 ◽  
Author(s):  
Joseph W. Tringe ◽  
Michael B. Zellner ◽  
Clifton H. Mortensen ◽  
Franco J. Gagliardi ◽  
Jerel A. Smith ◽  
...  
Keyword(s):  
Three Dimensional ◽  
X Rays ◽  
Corner Turning

A Contribution to the Analysis of Corner Turning Rib Problems

2006 ◽  
Vol 31 (4) ◽  
pp. 299-305 ◽  
Author(s):  
Jiří Vágenknecht ◽  
Vladislav Adamík
Keyword(s):  
Corner Turning

Tribological Influences of TiAlN Coating on Tool Wear for High-Speed Dry and Wet Machining of Steels

2004 ◽  
Author(s):  
Y. J. Lin ◽  
Samir A. Khrais
Keyword(s):  
High Speed ◽  
High Speed Machining ◽  
Structural Variations ◽  
Edge Chipping ◽  
Coated Tools ◽  
Coated Tool ◽  
Carbide Inserts ◽  
Turning Test ◽  
Cemented Carbide Inserts ◽  
Cutting Speeds

The tribological influences of PVD-applied TiAlN coatings on the wear of cemented carbide inserts and the microstructure wear behaviors of the coated tools under dry and wet machining are investigated. The turning test was conducted with variable high cutting speeds ranging from 210 m/min to 410m/min. The analyses based on the experimental results lead to strong evidences that conventional coolant has a retarded effect on TiAlN coatings under high-speed machining. Microwear mechanisms identified in the tests through SEM micrographs include edge chipping, micro-abrasion, micro-fatigue, micro-thermal, and micro-attrition. These micro-structural variations of coatings provide structure-physical alterations as the measures for wear alert of TiAlN coated tool inserts under high speed machining of steels.

Mit Einzelzähnen schneller zum Verschleiß*/Faster to wear with single teeth

2019 ◽  
Vol 109 (01-02) ◽  
pp. 8-13
Author(s):  
H.-C. Möhring ◽  
R. Eisseler ◽  
H. Ghassemi ◽  
Keyword(s):  
Machine Tools ◽  
Circular Saw ◽  
Single Tooth ◽  
The University ◽  
Turning Test

Standzeittests an Kreissägewerkzeugen sind in der Regel zeit- und materialintensiv. Am Institut für Werkzeugmaschinen (IfW) der Universität Stuttgart wird der Aufwand mithilfe von Einzahnversuchen deutlich verringert. Die Versuche basieren auf einem Leistendrehtest, der sich an die ehemalige VDI-Richtlinie VDI 3324 anlehnt und auf Drehmaschinen durchgeführt werden kann. Durch einfach gestaltete, wechselbare Leisten entsteht eine für das Sägen typische Schnittunterbrechung und es können beliebige Werkstoffe berücksichtigt werden.   Live time tests on circular saw tools are usually time-consuming and material-intensive. At the Institute for Machine Tools (IfW) of the University of Stuttgart, the required effort can be significantly reduced by conducting single tooth tests. The tests are based on a block turning test which adopts the former VDI guideline VDI 3324 and can be used on lathes. Simply designed and exchangeable blocks allow the typical cut interruption for sawing and consider any materials.

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