scholarly journals A novel approach to hydrogen recovery, storage and transport: Final technical report

1988 ◽  
Author(s):  
M. Fowler ◽  
J. Sangiovanni
2018 ◽  
Author(s):  
Massimo Stella

This technical report outlines the mechanisms and potential applications of SentiMental, a suite of natural language processing algorithm designed and implemented by Massimo Stella, Complex Science Consulting. The following technical report briefly outlines the novel approach of SentiMental in performing sentiment and emotional analysis by directly harnessing the whole structure of the mental lexicon rather than by using affect norms. Furthermore, this technical report outlines the direct emotional profiling and the visualisations currently implemented in version 0.1 of SentiMental. Features under development and current limitations are also outlined and discussed.This technical report is not meant as a publication. The author holds full copyright and any reproduction of parts of this report must be authorised by the copyright holder. SentiMental represents a work in progress, so do not hesitate to get in touch with the author for any potential feedback.


2021 ◽  
pp. 19-23
Author(s):  
Myles Dworkin

Background: Brachial plexus injects are common procedures for pain management of the upper limb. Complications from theses injections, however, can be severe leading to permanent neurological deficit. The purpose of this technical report is to introduces a safe novel approach for brachial plexus injections. Case Presentation: A 45-year-old woman with type 2 complex region pain disorder underwent a novel brachial plexus injection. The patient was brought to the operating room where fluoroscopy was used to locate the T2 lamina. A 17-gauge introducer needle was maneuvered through the interlaminar space and into the epidural space. The stylet was removed and a Brevi Kath® (Epimed, Dallas, TX) was passed through the C7-T1 foramen into the brachial plexus region. Contrast was used to ensure proper placement and absence of vascular pickup. The injection was then given, and the catheter withdrawn. The procedure was done without complication and the patient had a 40% reduction in pain symptoms based on a visual analog scale. She was cleared to restart physical therapy. Conclusions: This novel technique approaches the brachial plexus by gaining access to the thoracic epidural space and following the spinal nerves through their respective foramen. The use of fluoroscopy and contrast ensures correct placement of injection. A blunt catheter limits the risk of injury. This approach may benefit patients who have failed standard techniques using local landmarks or those that are not ideal candidates due to previous injury or pre-existing conditions. Key words: Interventional pain, injection, brachial plexus, pain management, fluoroscopy


Neurographics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 241-246
Author(s):  
J. Khader Eliyas ◽  
A. Rubinov ◽  
M. Ashenhurst ◽  
A.P. Mitha ◽  
M. Eesa

Orbital AVFs, abnormal vascular connections between orbital arteries and veins, are extremely rare. Often traumatic, few reports of spontaneous orbital fistulas have been reported so far. Treatment is warranted for deteriorating visual symptoms, but obliteration of the fistula can be challenging. We present such a case that symptomatically mirrored a carotid cavernous fistula. A novel approach was used by traversing a thrombosed superior ophthalmic vein to embolize the lesion. In addition, a complete literature review is presented.


2017 ◽  
Vol 43 (7) ◽  
pp. 1656-1660 ◽  
Author(s):  
Soudabeh Fazeli Dehkordy ◽  
Kathryn J. Fowler ◽  
Tanya Wolfson ◽  
Saya Igarashi ◽  
Carolina P. Lamas Constantino ◽  
...  

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.


2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687


Sign in / Sign up

Export Citation Format

Share Document