scholarly journals Integral cell scale-up and performance verification. Final report

1979 ◽  
Author(s):  
L. Handley ◽  
W. Houghby ◽  
W. Johnson ◽  
T. Schiller ◽  
H. Stryker
Keyword(s):  
Scale Up ◽  
Final Report ◽  
Performance Verification ◽  
And Performance

Final Report: Scale-up of Algal Biofuel Production Using Waste Nutrients

2018 ◽  
Author(s):  
Tryg Lundquist ◽  
◽  
Ruth Spierling ◽  
◽  
Keyword(s):  
Scale Up ◽  
Biofuel Production ◽  
Final Report ◽  
Algal Biofuel

scholarly journals Solid Form and Phase Transformation Properties of Fexofenadine Hydrochloride during Wet Granulation Process

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 802
Author(s):  
Suye Li ◽  
Hengqian Wu ◽  
Yanna Zhao ◽  
Ruiyan Zhang ◽  
Zhengping Wang ◽  
...  
Keyword(s):  
Phase Transition ◽  
Phase Transformation ◽  
Water Content ◽  
Scale Up ◽  
Small Scale ◽  
Dissolution Behavior ◽  
Wet Granulation ◽  
Water Addition ◽  
Granulation Process ◽  
And Performance

The quality control of drug products during manufacturing processes is important, particularly the presence of different polymorphic forms in active pharmaceutical ingredients (APIs) during production, which could affect the performance of the formulated products. The objective of this study was to investigate the phase transformation of fexofenadine hydrochloride (FXD) and its influence on the quality and performance of the drug. Water addition was key controlling factor for the polymorphic conversion from Form I to Form II (hydrate) during the wet granulation process of FXD. Water-induced phase transformation of FXD was studied and quantified with XRD and thermal analysis. When FXD was mixed with water, it rapidly converted to Form II, while the conversion is retarded when FXD is formulated with excipients. In addition, the conversion was totally inhibited when the water content was <15% w/w. The relationship between phase transformation and water content was studied at the small scale, and it was also applicable for the scale-up during wet granulation. The effect of phase transition on the FXD tablet performance was investigated by evaluating granule characterization and dissolution behavior. It was shown that, during the transition, the dissolved FXD acted as a binder to improve the properties of granules, such as density and flowability. However, if the water was over added, it can lead to the incomplete release of the FXD during dissolution. In order to balance the quality attributes and the dissolution of granules, the phase transition of FXD and the water amount added should be controlled during wet granulation.

scholarly journals Performance Evaluations of Distributed File Systems for Scientific Big Data in FUSE Environment

Electronics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1471
Author(s):  
Jun-Yeong Lee ◽  
Moon-Hyun Kim ◽  
Syed Asif Raza Raza Shah ◽  
Sang-Un Ahn ◽  
Heejun Yoon ◽  
...  
Keyword(s):  
Data Storage ◽  
Scale Up ◽  
File Systems ◽  
Performance Evaluations ◽  
Distributed File Systems ◽  
Data Intensive Computing ◽  
Data Intensive ◽  
Tremendous Amount ◽  
Computing Environments ◽  
And Performance

Data are important and ever growing in data-intensive scientific environments. Such research data growth requires data storage systems that play pivotal roles in data management and analysis for scientific discoveries. Redundant Array of Independent Disks (RAID), a well-known storage technology combining multiple disks into a single large logical volume, has been widely used for the purpose of data redundancy and performance improvement. However, this requires RAID-capable hardware or software to build up a RAID-enabled disk array. In addition, it is difficult to scale up the RAID-based storage. In order to mitigate such a problem, many distributed file systems have been developed and are being actively used in various environments, especially in data-intensive computing facilities, where a tremendous amount of data have to be handled. In this study, we investigated and benchmarked various distributed file systems, such as Ceph, GlusterFS, Lustre and EOS for data-intensive environments. In our experiment, we configured the distributed file systems under a Reliable Array of Independent Nodes (RAIN) structure and a Filesystem in Userspace (FUSE) environment. Our results identify the characteristics of each file system that affect the read and write performance depending on the features of data, which have to be considered in data-intensive computing environments.

scholarly journals Video Scanning Hartmann Optical Testing of State-of-the-Art Parabolic Trough Concentrators

Solar Energy ◽  
2006 ◽  
Author(s):  
Tim Wendelin ◽  
Ken May ◽  
Randy Gee
Keyword(s):  
Technology Development ◽  
Scale Up ◽  
Test System ◽  
Optical Testing ◽  
Parabolic Trough ◽  
Energy Technologies ◽  
Energy Needs ◽  
World Energy ◽  
Optical Test ◽  
And Performance

Significant progress has been made recently in solar parabolic trough technology development and deployment. Part of this success is due to the changing world energy scenario and the recognition that viable renewable energy technologies can play a role in supplying world energy needs. Part is also due to ongoing collaborative efforts by industry and the Department of Energy’s (DOE) Concentrating Solar Power Program (CSP) to enhance the state of the technology in terms of both cost and performance. Currently, there are two trough concentrator projects which the DOE CSP program is supporting. One company, Solargenix, is developing a design to be used in a 64MW plant outside of Boulder City, Nevada. This design is based on the original LUZ LS-2 trough concentrators employed at the Solar Electric Generating Systems (SEGS) plants in Southern California. Another company, Industrial Solar Technology (IST), is working on a scale-up of their design used historically for process heat applications. Very different from the LS-2 approach, this design is still in the research and development stages. One way in which the DOE CSP parabolic trough program assists industry is by providing optical testing and qualification of their concentrator designs. This paper describes the Video Scanning Hartmann Optical Test System (VSHOT) used to optically test both of these designs. The paper also presents the results of tests performed in the past year and what impact the testing has had on the developmental direction of each design.

scholarly journals Final Report, Project: Advanced Oxy-Combustion Technology Development and Scale Up for New and Existing Coal-Fired Power Plants (Phase II)

2019 ◽  
Author(s):  
Mark Fitzsimmons ◽  
Doug M. Heim ◽  
William Follett ◽  
Stevan Jovanovic ◽  
Makini Byron ◽  
...  
Keyword(s):  
Phase Ii ◽  
Power Plants ◽  
Technology Development ◽  
Scale Up ◽  
Final Report ◽  
Combustion Technology

scholarly journals Ethical Codes as Instruments for Cooperative Sustainability

2016 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Nooraslinda Abdul Aris ◽  
Rohana Othman ◽  
Safawi Abdul Rahman ◽  
Marziana Madah Marzuki ◽  
Wan Mohd Yusof Wan Chik
Keyword(s):  
Social Responsibility ◽  
Scientific Literature ◽  
Scale Up ◽  
Past Research ◽  
Social Enterprises ◽  
Positive Contribution ◽  
Ethical Codes ◽  
Norms And Values ◽  
And Performance ◽  
Desirable Behavior

Numerous ethical breaches have made cooperatives, and their management endures pressure to improve their image and ethical performance. One of the ways identified is by adopting ethical codes. Codes are regarded as instruments to enhance social responsibility that contain open guidelines describing desirable behavior and closed guidelines prohibiting certain behaviors. Codes clarify the norms and values organizations seek to uphold. Regarded as social enterprises, cooperatives are compelled to scale up their operations for sustainability reasons towards positive contribution to the national economy. Past research on ethical codes affecting behavior, attitude and performance has yielded mixed results. In addition, there are very few studies devoted to cooperatives. This paper presents the results of scientific literature, highlighting how ethical codes and sustainability may progressively improve the cooperatives’ image and reputation in the eyes of the stakeholders.     Keywords: ethical codes, social responsibility, sustainability, cooperative

Sign in / Sign up

Export Citation Format

Share Document