scholarly journals Attenuation of G{sub 2} cell cycle checkpoint control in human tumor cells is associated with increased frequencies of unrejoined chromosome breaks but not increased cytotoxicity following radiation exposure

1997 ◽  
Author(s):  
J.L. Schwartz ◽  
J. Cowan ◽  
D.J. Grdina
Keyword(s):  
Cell Cycle ◽  
Radiation Exposure ◽  
Tumor Cells ◽  
Human Tumor ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Human Tumor Cells ◽  
Chromosome Breaks ◽  
Cycle Checkpoint

DNA damage checkpoint kinases in cancer

2020 ◽  
Vol 22 ◽  
Author(s):  
Hannah L. Smith ◽  
Harriet Southgate ◽  
Deborah A. Tweddle ◽  
Nicola J. Curtin
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Environmental Dna ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Integrated Network ◽  
Checkpoint Kinases ◽  
G1 Checkpoint ◽  
Cycle Checkpoint ◽  
High Level

Abstract DNA damage response (DDR) pathway prevents high level endogenous and environmental DNA damage being replicated and passed on to the next generation of cells via an orchestrated and integrated network of cell cycle checkpoint signalling and DNA repair pathways. Depending on the type of damage, and where in the cell cycle it occurs different pathways are involved, with the ATM-CHK2-p53 pathway controlling the G1 checkpoint or ATR-CHK1-Wee1 pathway controlling the S and G2/M checkpoints. Loss of G1 checkpoint control is common in cancer through TP53, ATM mutations, Rb loss or cyclin E overexpression, providing a stronger rationale for targeting the S/G2 checkpoints. This review will focus on the ATM-CHK2-p53-p21 pathway and the ATR-CHK1-WEE1 pathway and ongoing efforts to target these pathways for patient benefit.

scholarly journals c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle

Oncogene ◽  
2007 ◽  
Vol 27 (13) ◽  
pp. 1905-1915 ◽  
Author(s):  
H Wang ◽  
S Mannava ◽  
V Grachtchouk ◽  
D Zhuang ◽  
M S Soengas ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cells ◽  
Human Tumor ◽  
Human Tumor Cells
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