scholarly journals TWO-YEAR CHRONIC ORAL TOXICITY STUDY WITH LOW DOSE IRRADIATED PAPAYAS IN ALBINO RATS.

1971 ◽  
Author(s):  
Keyword(s):  
Low Dose ◽  
Toxicity Study ◽  
Albino Rats ◽  
Oral Toxicity

Acute and subacute toxicity assessment of Madhulai Manappagu (Siddha herbal syrup formulation) in animal model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Meenakshi Sundaram Malayappan ◽  
Gayathri Natarajan ◽  
Logamanian Mockaiyathevar ◽  
Meenakumari Ramasamy
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Oral Route ◽  
Toxicity Assessment ◽  
Toxicity Study ◽  
Female Rats ◽  
Albino Rats ◽  
Oral Toxicity ◽  
Gross Pathology ◽  
Toxicity Studies

Abstract Objectives Madhulai Manappagu – a well-known sastric and widely prescribed Siddha herbal syrup formulation indicated for treating Veluppu Noi (Anaemia especially Iron deficiency Anaemia) has been in day today practice in Tamil Nadu for a quite longer decades. The syrup is a herbal preparation which has a sweet pleasant odour and a palatable taste, contain the juice of pomegranate (Punica granatum L.) as the main ingredient. Though the formulation is a fruit juice, the safety profile of the syrup is not established and is being marketed without toxicological evaluation. The study is aimed at ascertaining the acute and sub-acute toxicity assessment of Madhulai Manappagu in Wistar Albino rats. Methods The acute and sub-acute (28day repeated oral) toxicity studies were performed as per the guidelines mentioned in the Organization for Economic Cooperation and Development (OECD) 423 (adopted on December 2001) and TG 407 (adopted on October 2008) with slight modifications respectively. For acute toxicity study, three female rats were randomly selected as control; three female rats were randomly selected and were administered a single dose of 5,000 mg/kg body weight per oral route. For sub-acute (28day repeated oral) toxicity studies, three doses of test drug MM of 500 mg/kg/day (low dose), 750 mg/kg/day (intermittent dose) and 1,000 mg/kg/day (high dose) were selected for administration. Both sexes of Wistar Albino rats were randomized into four groups of 10 animals each (five males, five females). Group I was kept as control group. Group II, III and IV served as low, intermittent and high doses of MM respectively. Animals were observed for mortality, morbidity, body weight changes, feed and water intake. Haematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight and histopathological examination were performed. Results In the acute toxicity study, rats showed no toxicological signs on behavior, gross pathology and body weight of rats when treated with a single dose of 5,000 mg/kg body weight per oral route. In the subacute (28 days repeated oral) toxicity study, rats have showed no significant changes on behavior, gross pathology, body weight, and hematological and biochemical parameters when treated with Madhulai Manappagu in three different doses. Conclusions The toxicity studies which include both acute and 28 days repeated (subacute) oral toxicity studies, revealed no observed adverse effect level (NOAEL) of Madhulai Manappagu in animals. Thus the safety of the drug in human usage was ensured.

Mesovarial Leiomyomas in Rats in a Chronic Toxicity Study of Soterenol Hydrochloride

1971 ◽  
Vol 8 (5-6) ◽  
pp. 452-457 ◽  
Author(s):  
L. W. Nelson ◽  
W. A. Kelly
Keyword(s):  
Smooth Muscle ◽  
Adrenergic Receptors ◽  
Dose Group ◽  
Chronic Toxicity ◽  
Low Dose ◽  
Toxicity Study ◽  
Ovarian Cysts ◽  
High Dose ◽  
Oral Toxicity ◽  
Β Adrenergic Receptors

In an 18-month oral toxicity study of soterenol hydrochloride, a stimulant of the β-adrenergic receptors, mesovarial leiomyomas were observed in three of 30 low-dose, six of 30 middle-dose and 10 of 30 high-dose rats. There was also an increase in the prevalence of ovarian cysts and of focal hyperplasia of smooth muscle in the mesovaria in the treated rats, especially in the high-dose group.

scholarly journals Evaluation of Safety of Karnasphota (Cardiospermum halicacabum L.) Leaf through Acute Oral Toxicity Study and Repeated Dose: 28-day Oral Toxicity Study in Wistar Albino Rats

2018 ◽  
Vol 3 (1) ◽  
pp. 15-22
Author(s):  
Sudesh N Gaidhani ◽  
Kandiyoor R Surabhi ◽  
Yalwar R Sanjayakumar ◽  
Paravazhi Radhakrishnan ◽  
Natarajan Thamizhselvam ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Albino Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Wistar Albino Rats

Acute Oral Toxicity study of ViproTM Polyherbal Formulation in Wistar albino rats

2020 ◽  
Vol 23 (15) ◽  
Author(s):  
S. Saradha ◽  
E. Abinaya ◽  
V. Vivek ◽  
D. Prabhu ◽  
Shaleesha A Stanley ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Albino Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Polyherbal Formulation ◽  
Wistar Albino Rats

scholarly journals ANTI-ULCER STUDY OF STANDARDIZED ETHANOL ROOT EXTRACT OF AGANOSMA DICHOTOMA AND ISOLATED URSOLIC ACID

2017 ◽  
Vol 9 (4) ◽  
pp. 172
Author(s):  
Deepali Pandey ◽  
Apurva Joshi ◽  
Siva Hemalatha
Keyword(s):  
Ursolic Acid ◽  
Gastric Volume ◽  
Gastric Ph ◽  
Toxicity Study ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Histopathological Study ◽  
Root Extract ◽  
Oral Toxicity ◽  
Proton Pump Inhibition

Objective: Aganosma dichotoma K. Schum (Apocynaceae) has been traditionally used as an Ayurvedic ulcer treatment and the study scientifically validates the antiulcer effect of A. dichotoma ethanol root extract (EAD).Methods: The studies included the isolation, quantification of ursolic acid through HPTLC. Acute and sub-acute toxicity study of EAD for 28 d and antiulcer effect of ursolic acid (50 mg/kg, p. o.), EAD (100, 200 and 400 mg/kg, p. o.) were also evaluated on both the physical (pyloric ligation, PL; cold restrain stress, CRS;) and chemical (absolute ethanol, aspirin, ASP;) induced ulcer in Charles Foster albino rats for 7 d. The various gastric-ulcer parameters, viz. gastric pH, volume, acid-pepsin output, DNA content, H+K+-ATPase activity, mucus content, microvascular permeability, antioxidant enzyme, and gastric histopathological study were performed.Results: The isolated ursolic acid was characterized by NMR and mass spectrometer and quantified through HPTLC in EAD (4.26% w/w). Acute oral toxicity study indicated that LD50 of extract was ≥ 5 g/kg. EAD at the dose of 200 and 400 mg/kg, p. o. reduced the ulcer score in both physical and chemical-induced ulcer models. In PL model EAD (400 mg/kg, p. o.) and ursolic acid (50 mg/kg, p. o.) showed antisecretory property by inhibiting aggressive factors [increase in gastric pH (35.02%, 26.73%), whereas decreased gastric volume (43.55%, 34.35%) and acid-pepsin output (75.23%, 68.81%), respectively]. EAD at 400 mg/kg p. o. showed significant effect on proton pump inhibition while ursolic acid didn’t showed any effect.Conclusion: The effects of EAD were accredited mainly to the offensive mechanism and justify its traditional usage in the treatment of gastric ulcers.

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