scholarly journals LONG TERM EFFECTS OF PRENATAL X-IRRADIATION ON CEREBRAL CORTEX. Technical Progress Report, December 1, 1966--December 1, 1967.

1968 ◽  
Author(s):  
K.R. Brizzee
Keyword(s):  
Cerebral Cortex ◽  
Technical Progress ◽  
Progress Report ◽  
Long Term Effects ◽  
X Irradiation

Short- and long-term effects of low-dose prenatal X-irradiation in mouse cerebral cortex, with special reference to neuronal migration

1997 ◽  
Vol 93 (5) ◽  
pp. 443-449 ◽  
Author(s):  
S. Fushiki ◽  
Yasuko Hyodo-Taguchi ◽  
Chikako Kinoshita ◽  
Yuji Ishikawa ◽  
Tomohisa Hirobe
Keyword(s):  
Cerebral Cortex ◽  
Special Reference ◽  
Neuronal Migration ◽  
Low Dose ◽  
Long Term Effects ◽  
Mouse Cerebral Cortex ◽  
X Irradiation ◽  
Short And Long Term

scholarly journals Acute action of DSP-4 on central norepinephrine axons: biochemical and immunohistochemical evidence for differential effects.

1989 ◽  
Vol 37 (9) ◽  
pp. 1435-1442 ◽  
Author(s):  
R Grzanna ◽  
U Berger ◽  
J M Fritschy ◽  
M Geffard
Keyword(s):  
Cerebral Cortex ◽  
High Performance ◽  
Direct Evidence ◽  
Selective Vulnerability ◽  
Brain Regions ◽  
Acute Effects ◽  
Long Term Effects ◽  
Immunohistochemical Evidence ◽  
Immunohistochemical Studies

Previous immunohistochemical studies of the long-term effects of the noradrenergic neurotoxin DSP-4 have demonstrated a remarkably selective vulnerability of norepinephrine (NE) axons of the locus coeruleus (LC). NE axons originating in non-LC NE neurons appear to be largely resistant to the neurotoxic action of DSP-4. We conducted this study to evaluate the acute effects of DSP-4 on NE axons in four different brain regions: cerebral cortex, cerebellum, ventral forebrain, and hypothalamus. NE levels were determined by high-performance liquid chromatography (HPLC) 6 and 24 hr and 14 days after DSP-4 administration. NE axons in these brain regions were visualized in brain sections at 6 and 24 hr after drug treatment, using a specific antiserum to NE. HPLC assays revealed profound reductions of NE levels in cerebral cortex and cerebellum, but only minor decreases in ventral forebrain and hypothalamus. NE immunohistochemistry showed dramatic differences in the acute effects of DSP-4 on NE axon staining: nearly complete loss of staining in cortex and cerebellum, in contrast to an almost unchanged staining pattern in ventral forebrain and hypothalamus. This study demonstrates that NE immunohistochemistry is a valuable tool to assess the acute effects of DSP-4 on NE axons in different brain regions. The results provide the first direct evidence that NE axons are not uniformly acted on by DSP-4 and suggest that the acute effects of DSP-4 are restricted to LC axons.

The Long-Term Effects of X-Irradiation on the Ability of the Spleen to Support Clonogenic Proliferation

1974 ◽  
Vol 58 (3) ◽  
pp. 417 ◽  
Author(s):  
D. F. Nelson ◽  
J. T. Chaffey ◽  
S. Hellman
Keyword(s):  
Long Term Effects ◽  
X Irradiation

Hyperthermia‐induced seizures produce long‐term effects on the functionality of adenosine A 1 receptor in rat cerebral cortex

2020 ◽  
Vol 80 (1) ◽  
pp. 1-12
Author(s):  
María Crespo ◽  
David Agustín León‐Navarro ◽  
María Ángeles Ruíz ◽  
Mairena Martín
Keyword(s):  
Cerebral Cortex ◽  
Rat Cerebral Cortex ◽  
Long Term Effects
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