scholarly journals Safety test No. S-6, launch pad abort sequential test phase III: FSA impacts

1975 ◽  
Author(s):  
E.C. Snow ◽  
C.E. Frantz
Keyword(s):  
Test Phase ◽  
Sequential Test ◽  
Phase Iii ◽  
Safety Test

Regional deposition of 3.6-micron particles and lung function in asthmatic subjects

1991 ◽  
Vol 71 (6) ◽  
pp. 2238-2243 ◽  
Author(s):  
M. Svartengren ◽  
M. Anderson ◽  
G. Bylin ◽  
K. Philipson ◽  
P. Camner
Keyword(s):  
Airway Resistance ◽  
Regression Line ◽  
Test Phase ◽  
Phase Iii ◽  
Poor Correlation ◽  
Small Airways ◽  
Single Breath ◽  
Regional Deposition ◽  
Severe Asthmatic ◽  
Highly Correlated

In a group of moderately severe asthmatic subjects, regional deposition of 3.6-microns (aerodynamic diameter) monodispersed Teflon particles labeled with 111In was studied twice. The particles were inhaled with maximally deep inhalation at 0.5 l/s. Lung retention was measured at 0, 6, 24, and 48 h by use of a profile scanner equipped with two 13 x 5-cm NaI crystals. The retentions at 24 (Ret24) and 48 h were highly correlated (r = 0.96 with a slope of the regression line close to 1). There was a poor correlation between retention at 6 h and Ret24 (r = 0.54). The Ret24 values at the two exposures were well correlated (r = 0.86). There were significant correlations between airway resistance as well as single-breath nitrogen test phase III and Ret24 (r = 0.70 and 0.67, respectively). The correlation between single-breath nitrogen test phase III and Ret24 persisted also when only subjects within a narrow interval of airway resistance were included. The study indicates that regional deposition can be studied by measurements of Ret24 in subjects with moderately severe asthma and that it is dependent on changes in both large and small airways.

The Influences of Step Aerobics Routines on Exercise Capacity Among Middle-Aged Women

2019 ◽  
pp. 75-80
Author(s):  
Anca -Raluca Tanasă ◽  
Iulian-Marius Dumitru ◽  
Cristina-Elena Moraru ◽  
Florin Nichifor
Keyword(s):  
Quality Of Life ◽  
Body Mass Index ◽  
Test Phase ◽  
Phase Iii ◽  
Middle Aged ◽  
Negative Effects ◽  
Beneficial Effects ◽  
Independent Variable ◽  
Research Plan

Step aerobics is a form of practicing of aerobic fitness representing an efficient and pleasant alternative in the process of obtaining optimal physical condition. The purpose of this study is the confirm the hypothesis according to which the practiceof step aerobics routines middle-aged women has an important role in improving the quality of life. The research was carried out throughout the year 2018, on a sample of 20 female adults attending Clubul D inIaşi, who were divided into two groups: experimental and witness and it was carried out throughout three phases: phase I: selecting and studying bibliography, developing the research plan and determining the sample; phase II: applying the initial tests: Body mass index-BMIand Ruffier Test; phase III: applying the final tests, comparatively analysing the results and the progress obtained, to point out the conclusions. In order to analyse the results we used the ANOVA statistical analysis test. The resultsindicate that the independent variable that we applied does not influence the results of the IMC (p= 0,2805), but the Ruffier index presents statistically significant changes (p=˂0,0001). As a general conclusion, we want to emphasize that the sport for heath, more exactly the step-aerobic programs, improves the negative effects of some diseases, the physical deficiencies, functional or trauma to which the human body may be subjected, and thus contributing to its recovery. The beneficial effects of the step-aerobic programs can contribute in a good measure to improve the quality of life.

Comprehensive Analysis of Passive Safety Test Phase IIB in the Fast Flux Test Facility

1994 ◽  
Vol 107 (1) ◽  
pp. 23-37 ◽  
Author(s):  
Akira Yamaguchi ◽  
Hajime Niwa ◽  
Mitsuaki Yamaoka ◽  
Kazuyuki Tsukimori ◽  
Yoshio Shimakawa ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Test Phase ◽  
Test Facility ◽  
Passive Safety ◽  
Safety Test ◽  
Fast Flux

The CFTA evaluation of alternatives program: An evaluation of in vitro alternatives to the draize primary eye irritation test. (Phase III) surfactant-based formulations

1996 ◽  
Vol 34 (1) ◽  
pp. 79-117 ◽  
Author(s):  
S.D. Gettings ◽  
R.A. Lordo ◽  
K.L. Hintze ◽  
D.M. Bagley ◽  
P.L. Casterton ◽  
...  
Keyword(s):  
Test Phase ◽  
Phase Iii ◽  
Eye Irritation ◽  
Irritation Test

RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum

2017 ◽  
Vol 1 (6) ◽  
pp. 533-537
Author(s):  
Lorenz von Seidlein ◽  
Borimas Hanboonkunupakarn ◽  
Podjanee Jittmala ◽  
Sasithon Pukrittayakamee
Keyword(s):  
Protective Efficacy ◽  
Age Groups ◽  
Sub Saharan Africa ◽  
Phase Iii ◽  
European Medicines Agency ◽  
Older Children ◽  
Pivotal Phase ◽  
Malaria Epidemiology ◽  
Maximum Benefit ◽  
Sub Saharan

RTS,S/AS01 is the most advanced vaccine to prevent malaria. It is safe and moderately effective. A large pivotal phase III trial in over 15 000 young children in sub-Saharan Africa completed in 2014 showed that the vaccine could protect around one-third of children (aged 5–17 months) and one-fourth of infants (aged 6–12 weeks) from uncomplicated falciparum malaria. The European Medicines Agency approved licensing and programmatic roll-out of the RTSS vaccine in malaria endemic countries in sub-Saharan Africa. WHO is planning further studies in a large Malaria Vaccine Implementation Programme, in more than 400 000 young African children. With the changing malaria epidemiology in Africa resulting in older children at risk, alternative modes of employment are under evaluation, for example the use of RTS,S/AS01 in older children as part of seasonal malaria prophylaxis. Another strategy is combining mass drug administrations with mass vaccine campaigns for all age groups in regional malaria elimination campaigns. A phase II trial is ongoing to evaluate the safety and immunogenicity of the RTSS in combination with antimalarial drugs in Thailand. Such novel approaches aim to extract the maximum benefit from the well-documented, short-lasting protective efficacy of RTS,S/AS01.

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