scholarly journals The role of clouds and oceans in global greenhouse warming. Final report

1996 ◽  
Author(s):  
M.I. Hoffert
2008 ◽  
Vol 363 (1504) ◽  
pp. 2745-2754 ◽  
Author(s):  
Euan G Nisbet ◽  
R. Ellen R Nisbet

Rubisco I's specificity, which today may be almost perfectly tuned to the task of cultivating the global garden, controlled the balance of carbon gases and O 2 in the Precambrian ocean and hence, by equilibration, in the air. Control of CO 2 and O 2 by rubisco I, coupled with CH 4 from methanogens, has for the past 2.9 Ga directed the global greenhouse warming, which maintains liquid oceans and sustains microbial ecology. Both rubisco compensation controls and the danger of greenhouse runaway (e.g. glaciation) put limits on biological productivity. Rubisco may sustain the air in either of two permissible stable states: either an anoxic system with greenhouse warming supported by both high methane mixing ratios as well as carbon dioxide, or an oxygen-rich system in which CO 2 largely fulfils the role of managing greenhouse gas, and in which methane is necessarily only a trace greenhouse gas, as is N 2 O. Transition from the anoxic to the oxic state risks glaciation. CO 2 build-up during a global snowball may be an essential precursor to a CO 2 -dominated greenhouse with high levels of atmospheric O 2 . Photosynthetic and greenhouse-controlling competitions between marine algae, cyanobacteria, and terrestrial C3 and C4 plants may collectively set the CO 2  : O 2 ratio of the modern atmosphere (last few million years ago in a mainly glacial epoch), maximizing the productivity close to rubisco compensation and glacial limits.


2004 ◽  
Vol 68 (1) ◽  
pp. S2 ◽  
Author(s):  
Mary Lee ◽  
Marialice Bennett ◽  
Patricia Chase ◽  
Dick Gourley ◽  
Donald Letendre ◽  
...  

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5548-5548
Author(s):  
Fulvia Pedani ◽  
Mario Airoldi ◽  
Massimiliano Garzaro ◽  
Luca Raimondo ◽  
Simona Carnio ◽  
...  

5548 Background: RMSGM are not amenable to the usual treatment with surgery and post-operative radiotherapy. The role of chemotherapy (CT) for RMSGM is palliative only. VNB showed moderate activity in our experience (Bull Cancer 85:892;1998) and in a randomized phase II trial we had demonstrated that the DDP+VNB combination had a better outcome than VNB alone (Cancer 91:541; 2001). In this abstract we report the final results of this combination in 60 cases. Methods: From April 2001 to February 2009 , 60 cases with RMSGM were enrolled. All patients received the following regimen: DDP 80 mg/sm d.1 + VNB 25 mg/sm d. 1,8 every 3 weeks. The study foresees a maximum of 6 cycles. Results: Patients characteristics were as follows: 35 males (58%) and 25 females (42%).; median age: 56 yrs (range 20-68); median ECOG PS: 1 (0-2); histology: adenocarcinoma 15 (25%), adenoid cystic ca. 34 (57%), others 11 (18%); site of disease: local 30 (50%) , mts +/- local 30 (50%). Forty-two pts received DDP+VNB as first line CT (70%) while 18 pts (30%) had the combination as second-line CT (30%). After a median of 5 cycles of first line DDP+VNB responses were: 3 CR (7%), 10 PR (24%), 14 NC (33%) and 15 PD (36%). After a median of 4 cycles of second line CT responses were: 0 CR; 1 PR (5%), 6 NC (33%) 11 PD (62%). Median survival: 10 months (3-29) for first line CT ; 4 months (1-12) for second line CT. G3-4 toxicity: neutropenia (20%), anemia (12%), nausea/vomiting (12%) , peripheral toxicity (3%). Conclusions: DDP+VNB is an effective first line CT in RMSGM ; second line CT has a low palliative activity. Toxicity seems acceptable. This regimen could be suitable for an integration with new biologic target agents.


2017 ◽  
Vol 65 (2) ◽  
pp. 89-107 ◽  
Author(s):  
Kevin Rafter

Abstract A parliamentary inquiry into the Irish banking collapse was formally established in November 2014, tasked with examining relevant issues from the period of January 1992 to December 2013. In focusing on the role played by the media - and where reportage may have impacted on, or contributed to, the crisis - the Banking Inquiry heard from eight senior media executives who held either commercial or editorial positions in four media organisations in Ireland during the period of the economic boom and subsequent collapse. This article focuses on the engagement of these media witnesses with the inquiry, drawing on written submissions and oral evidence. Having reviewed the place of journalism in a democracy and examined the role of journalism during the economic crisis, the article considers the Banking Inquiry’s final report, specifically in relation to the media. The review concludes that this parliamentary inquiry did not assist in advancing a serious understanding of the work undertaken by the Irish media in the pre-2007 period and that, ultimately, for all involved this engagement was a missed opportunity.


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