scholarly journals FACTORS AFFECTING THYROID HORMONE SECRETION RATES AND UTILIZATION RATES IN MAMMALS USING $sup 131$I AS A TRACER. Comprehensive Report, 1968--1970.

1971 ◽  
Author(s):  
R.R. Anderson
1975 ◽  
Vol 40 (6) ◽  
pp. 1130-1135 ◽  
Author(s):  
R. R. Anderson ◽  
J. R. Harness

1973 ◽  
Vol 56 (9) ◽  
pp. 1159-1163 ◽  
Author(s):  
R.R. Anderson ◽  
M.H. Lu ◽  
J.P. Wippler ◽  
E.S. Hilderbrand

1983 ◽  
Vol 18 (1) ◽  
pp. 1-9 ◽  
Author(s):  
L. TEGLER ◽  
J. GILLQUIST ◽  
R. LINDVALL ◽  
S. ALMQVIST ◽  
P. ROOS

1985 ◽  
Vol 108 (2) ◽  
pp. 184-191 ◽  
Author(s):  
Bo Ahrén

Abstract. The effects of various α-adrenoceptor agonists and antagonists on blood radioiodine levels were studied in mice pre-treated with 125I and thyroxine. The non-selective α-adrenoceptor agonist noradrenaline and the selective α1-adrenoceptor agonist phenylephrine both enhanced blood radioiodine levels. Noradrenaline was more potent than phenylephrine. Contrary, the selective α2-adrenoceptor agonist clonidine depressed basal levels of blood radioiodine. The non-selective α-adrenoceptor antagonist phentolamine and the selective α1-adrenoceptor antagonist prazosin both inhibited the noradrenaline-induced elevation of radioiodine levels, whereas the α2-adrenoceptor antagonist yohimbine had no such effect, except at a high dose level. All three α-adrenoceptor agonists, noradrenaline, phenylephrine and clonidine, inhibited the radioiodine response to TSH. In addition, TSH-induced increase in radioiodine levels was inhibited by prazosin, whereas yohimbine had no effect. Phentolamine inhibited the radioiodine response to TSH when given 2 h prior to TSH, whereas when given 15 min prior to TSH the response to TSH was potentiated by Phentolamine. It is concluded, that under in vivo conditions in the mouse, α1-adrenoceptor activation stimulates basal thyroid hormone secretion and inhibits TSH-induced thyroid hormone secretion. Further, α2-adrenoceptor activation inhibits basal thyroid hormone secretion. In addition, TSH-induced thyroid hormone secretion is inhibited by α1-adrenoceptor antagonism. Thus, α-adrenoceptors induce both stimulatory and inhibitory effects of thyroid function.


1987 ◽  
Vol 113 (2) ◽  
pp. 183-192 ◽  
Author(s):  
C. H. G. Irvine ◽  
S. L. Alexander

ABSTRACT We have described a novel technique for collecting pituitary venous effluent in the horse by placing a cannula in the intercavernous sinus close to the outlet of the pituitary veins using a venous pathway unique to equids. Cannula placement and blood collection are carried out painlessly in fully conscious, ambulatory, unstressed animals. There is no interference to hypothalamic, pituitary or target organ function. The blood collected contains readily measurable concentrations of gonadotrophin-releasing hormone, and LH concentrations which can be up to 40 times those in concurrent peripheral blood samples. Four millilitre blood samples, a quantity which permits simultaneous measurement of many hypothalamic and pituitary hormones, can be collected at 2-min intervals for several days. Intercavernous sinus blood flow can be calculated allowing secretion rates of hypothalamic and pituitary hormones to be determined for any time-period. This model is uniquely useful for investigating the normal functional characteristics of several neuroendocrine and endocrine systems. J. Endocr. (1987) 113, 183–192


1986 ◽  
pp. 325-329
Author(s):  
Akira Nakai ◽  
Akio Nagasaka ◽  
Takako Ohyama ◽  
Toshihiro Aono ◽  
Rumi Masunaga ◽  
...  

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