scholarly journals Joint Work Plan for DPC Filler Testing.

2021 ◽  
Author(s):  
Mark Rigali
Keyword(s):  
Joint Work ◽  
Work Plan

JOINT WORK PLAN 2003–2005

2004 ◽  
Vol 7 (1-2) ◽  
pp. 73-89
Author(s):  
Mr. Arnulf Müller-Helmbrecht ◽  
Ramsar Bureau ◽  
Nicholas Davidson ◽  
Bert Lenten
Keyword(s):  
Joint Work ◽  
Work Plan

Coaction of Electrostatic and Hydrophobic Interactions: Dynamic Constraints on Disordered TrkA Juxtamembrane Domain

2019 ◽  
Author(s):  
Zichen Wang ◽  
Huaxun Fan ◽  
Xiao Hu ◽  
John Khamo ◽  
Jiajie Diao ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Function ◽  
Hydrophobic Interactions ◽  
Transmembrane Helix ◽  
Point Mutations ◽  
Salt Bridge ◽  
Receptor Activation ◽  
Membrane Dynamics ◽  
Juxtamembrane Domain ◽  
Joint Work

<p>The receptor tyrosine kinase family transmits signals into cell via a single transmembrane helix and a flexible juxtamembrane domain (JMD). Membrane dynamics makes it challenging to study the structural mechanism of receptor activation experimentally. In this study, we employ all-atom molecular dynamics with Highly Mobile Membrane-Mimetic to capture membrane interactions with the JMD of tropomyosin receptor kinase A (TrkA). We find that PIP<sub>2 </sub>lipids engage in lasting binding to multiple basic residues and compete with salt bridge within the peptide. We discover three residues insertion into the membrane, and perturb it through computationally designed point mutations. Single-molecule experiments indicate the contribution from hydrophobic insertion is comparable to electrostatic binding, and in-cell experiments show that enhanced TrkA-JMD insertion promotes receptor ubiquitination. Our joint work points to a scenario where basic and hydrophobic residues on disordered domains interact with lipid headgroups and tails, respectively, to restrain flexibility and potentially modulate protein function.</p>

Methodology of studying the mechanical properties of composite materials (reinforced concrete)

2018 ◽  
Vol 84 (12) ◽  
pp. 61-67
Author(s):  
V. A. Eryshev
Keyword(s):  
Mechanical Properties ◽  
Reinforced Concrete ◽  
Experimental Studies ◽  
Analytical Relationship ◽  
Hardened Concrete ◽  
Deformation Model ◽  
Joint Work ◽  
Concrete Shrinkage ◽  
Axial Tension ◽  
Tension And Compression

The mechanical properties of a complex composite material formed by steel and hardened concrete, are studied. A technique of operative quality control of new credible concrete and reinforcement, both in laboratory and field conditions is developed for determination of the strength and strain characteristics of materials, as well as cohesion forces determining their joint operation under load. The design of the mobile unit is presented. The unit provides a possibility of changing the direction of loading and testing the reinforced element of the given shape both for tension and compression. Moreover, the nomenclature of testing equipment and the number of molds for manufacturing concrete samples substantially decrease. Using the values of forcing resulting in concrete cracking when the joint work of concrete and reinforcement is disrupted the values of the inherent stresses and strains attributed to the concrete shrinkage are determined. An analytical relationship between the forces and deformations of the reinforced concrete sample with central reinforcement is derived for axial tension and compression, with allowance for strains and stresses in the reinforcement and concrete resulted from concrete shrinkage. The results of experimental studies are presented, including tension diagrams and diagrams of developing axial deformations with an increase in the load under the central loading of the reinforced elements. A methodology of accounting for stresses and deformations resulted from concrete shrinkage is developed. The applicability of the derived analytical relationships between stresses and deformations on the material diagrams to calculations of the reinforced concrete structures in the framework of the deformation model is estimated.

RUSSIAN-BELARUSIAN TUTORIAL "HISTORY OF THE GREAT PATRIOTIC WAR. ESSAYS ON THE SHARED HISTORY"

2020 ◽  
pp. 68-88
Author(s):  
Elena A. Kosovan ◽  
Keyword(s):  
Point Of View ◽  
Joint Work ◽  
Eurasian Economic Union ◽  
Shared History ◽  
Great Patriotic War ◽  
History Of ◽  
Independent States ◽  
The Republic ◽  
Integration Project ◽  
Second World

The paper provides a review on the joint Russian-Belarusian tutorial “History of the Great Patriotic War. Essays on the Shared History” published for the 75th anniversary of the victory in the Great Patriotic War. The tutorial was prepared within the project “Belarus and Russia. Essays on the Shared History”, implemented since 2018 and aimed at publishing a series of tutorials, which authors are major Russian and Belarusian historians, archivists, teachers, and other specialists in human sciences. From the author’s point of view, the joint work of specialists from the Russian Federation and the Republic of Belarus in such a format not only contributes to the deepening of humanitarian integration within the Union state, but also to the formation of a common educational system on the scale of the Commonwealth of Independent States or the Eurasian integration project (Eurasian Economic Union – EEU). The author emphasises the high research and educational significance of the publication reviewed when noting that the teaching of history in general and the history of the Second World War and the Great Patriotic War in particular in post-Soviet schools and institutes of higher education is complicated by many different issues and challenges (including external ones, which can be regarded as information aggression by various extra-regional actors).

RESULTS OF COOPERATION BETWEEN BREEDERS OF DIFFERENT INSTITUTIONS IN CREATION OF NEW GENERATION APPLE TREE

1970 ◽  
pp. 46-49
Author(s):  
Е. N. Sedov ◽  
T. V. Yanchuk ◽  
S. А. Korneeva ◽  
L. I. Dutova ◽  
Е. V. Ulianovskaya
Keyword(s):  
Selection Process ◽  
North Caucasus ◽  
Joint Work ◽  
Crop Breeding ◽  
Scientific Center ◽  
The North ◽  
State Register ◽  
Russian Research Institute ◽  
Apple Cultivars ◽  
New Generation

The experience in cooperation of breeders of different institutions in creating cultivars is shown. It is not always when the breeding institution has the necessary initial forms for selection. In this regard, there is a need to conduct separate stages of selection in different breeding institutions. For this purpose, a provision on authorship and continuity in the integrated work of several institutions in fruit breeding has been developed (Program and methods of fruit, berry and nut crop breeding. Annex. – Orel, 1995. – pp. 492-498). Breeding work of the Russian Research Institute of Fruit Crop Breeding (VNIISPK) and North Caucasian Federal Scientific Center of Horticulture, Viticulture, Winemaking can serve as a positive experience of creating new apple cultivars by two institutions. As a result of the joint work of these two institutions, 22 apple cultivars have been created, of which 9 have already been included in the state register of breeding achievements approved for use (zoned), including three cultivars for the conditions of the Middle zone of Russia – Aleksandr Boiko, Maslovskoye and Yablochny Spas and six cultivars for the conditions of the North Caucasus – Vasilisa, Karmen, Margo, Orfey, Soyuz and Talisman. Brief economical and biological characteristics of these cultivars are given in this paper. The obtained practical results indicate that in some cases, when creating modern cultivars that meet the requirements of production, it is necessary to use the knowledge of breeders, the source material and equipment of different breeding institutions, and carry out separate stages of the selection process in different institutions.

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