scholarly journals Ultra Low Density Shape Memory Polymer Foams With Tunable Physicochemical Properties for Treatment of intracranial Aneurysms

2013 ◽  
Author(s):  
Pooja Singhal
Author(s):  
Jingyu Wang ◽  
Jishan Luo ◽  
Robert Kunkel ◽  
Yingtao Liu ◽  
Bradley Bohnstedt ◽  
...  

This paper presents a novel medical device developed using shape memory polymer (SMP) foams for the endovascular treatment of intracranial aneurysms (ICAs). The SMP foam is fabricated, characterized, and experimentally investigated to better understand their potential for endovascular embolization of ICAs. Polyurethane-based SMP is successfully synthesized and characterized. The SMP foam is manufactured using cast molding, and characterized using an electro-thermal triggering mechanism to fully understand their shape recovery capability. The successful completion of this work will serve as a solid foundation for the development of new biomedical devices to treat intracranial aneurysms and develop an optimal releasing procedure for future animal study.


2010 ◽  
Vol 1274 ◽  
Author(s):  
Pooja Singhal ◽  
Thomas S Wilson ◽  
Duncan J Maitland

AbstractShape memory polymers (SMPs) are increasingly being considered for use in minimally invasive medical devices. For safe deployment of implanted devices it is important to be able to precisely control the actuation temperature of the device. In this study we report the effect of varying monomer composition on the glass transitions/actuation temperatures (Tg) of novel low density shape memory foams. The foams were based on hexamethylenediisocyanate (HDI), triethanolamine (TEA) and tetrakis (2-hydroxyl propyl) ethylenediamine (HPED), and were produced via a combination of chemical and physical blowing process. The process for post-foaming cleaning was also varied. Foams were characterized by DSC, DMA, and for shape memory. No clear trends were observed for foam samples without cleaning, and this was attributed to process chemicals acting as plasticizers. In foams cleaned via washing and/or sonication, the Tg was observed to decrease for compositions that were higher in the TEA content. Also, no change in shape memory behavior was observed for varying compositions. This work demonstrates the ability to tailor actuation transition temperature while maintaining shape memory behavior for low density foams suitable for aneurysm treatment.


2012 ◽  
Vol 214 (11) ◽  
pp. 1204-1214 ◽  
Author(s):  
Pooja Singhal ◽  
Anthony Boyle ◽  
Marilyn L. Brooks ◽  
Stephen Infanger ◽  
Steve Letts ◽  
...  

ChemPhysChem ◽  
2018 ◽  
Vol 19 (16) ◽  
pp. 1936-1936
Author(s):  
Mary Beth Browning Monroe ◽  
Alexandra D. Easley ◽  
Katie Grant ◽  
Grace K. Fletcher ◽  
Calla Boyer ◽  
...  

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 381 ◽  
Author(s):  
Landon Nash ◽  
Mary Browning Monroe ◽  
Yong-Hong Ding ◽  
Kendal Ezell ◽  
Anthony Boyle ◽  
...  

2015 ◽  
Author(s):  
Janice J. Song ◽  
Ijya Srivastava ◽  
Hani E. Naguib

2015 ◽  
Vol 40 ◽  
pp. 109-114 ◽  
Author(s):  
Loredana Santo ◽  
Fabrizio Quadrini ◽  
Pier Luigi Ganga ◽  
Valfredo Zolesi

2009 ◽  
Vol 5 (5) ◽  
pp. 1508-1518 ◽  
Author(s):  
Luigi De Nardo ◽  
Rachele Alberti ◽  
Alberto Cigada ◽  
L’Hocine Yahia ◽  
Maria Cristina Tanzi ◽  
...  

Author(s):  
D. Bellisario ◽  
F. Quadrini ◽  
L. Santo ◽  
L. Iorio ◽  
N. Gallo ◽  
...  

Abstract Composite repairing is an issue because of the size of the parts, the cost of the production equipment and the poor consolidation between the parent part and the repairing patches. In this study an out-of-autoclave procedure is proposed where the agglomeration pressure is provided by shape memory foams. These foams can be shaped in the desired form by means of a thermos-mechanical cycle, and provide additional pressure if constrained during recovery. Shape recovery is achieved by using the same thermal cycle which is necessary for the cure of the patches. In this study, thermoplastic shape memory foams have been characterized to evaluate the agglomeration pressure they can provide as a function of the compression strain. In order to show the feasibility of their application, the cure of a composite laminate has been performed by using pre-shaped shape memory foams. Results show that a good consolidation is achieved despite of the absence of a vacuum bag.


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