scholarly journals AeroValve Experimental Test Data Final Report

2014 ◽  
Author(s):  
Mark W. Noakes
Keyword(s):  
Test Data ◽  
Experimental Test ◽  
Final Report

1 Final Report on the Safety Assessment of Isostearyl Neopentanoate

1985 ◽  
Vol 4 (3) ◽  
pp. 1-22 ◽  
Keyword(s):  
Test Data ◽  
Clinical Studies ◽  
Safety Assessment ◽  
Final Report ◽  
Cosmetic Products ◽  
Short And Long Term ◽  
Cosmetic Formulation

Isostearyl Neopentanoate, the ester of Isostearyl Alcohol and Neopentanoic Acid, is used in cosmetic products as an emollient at concentrations up to 50 percent. The undiluted ingredient at doses up to 4 ml/kg was shown to be relatively non-toxic in short-and long-term feeding studies. Test data from animal and clinical studies indicate the undiluted ingredient is neither an irritant nor a sensitizer. A cosmetic formulation containing 16 percent Isostearyl Neopentanoate produced no phototoxicity and no photoallergenicity. Mutagenicity, carcinogenicity, and teratogenicity data were not available. Isostearyl Neopentanoate was not considered to be a significant comedogenic agent. On the basis of available data, it is concluded that this ingredient is safe as a cosmetic ingredient in its present practices of use.

2 Final Report on the Safety Assessment of Fossil and Synthetic Waxes

1984 ◽  
Vol 3 (3) ◽  
pp. 43-99 ◽  
Keyword(s):  
Test Data ◽  
Safety Assessment ◽  
Clinical Test ◽  
Final Report ◽  
Cosmetic Ingredients ◽  
Toxicological Test

Toxicological test data on Ozokerite, Ceresin, Montan Wax, Paraffin, Microcrystalline Wax, Emulsifying Wax N.F., Synthetic Wax and Synthetic Beeswax are presented. Based on the documented animal and clinical test data, it is concluded that these waxes are safe for use as cosmetic ingredients in the present practices of concentration and use.

Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate

1992 ◽  
Vol 11 (4) ◽  
pp. 497-507 ◽  
Keyword(s):  
Test Data ◽  
Mutagenic Activity ◽  
Metabolic Activation ◽  
Female Rats ◽  
Final Report ◽  
Cosmetic Products ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cosmetic Ingredients ◽  
Mouse Lymphoma Assay

Oxyquinoline is a heterocyclic phenol which is used as a fungicide and bactericide in cosmetic formulations at concentrations at, or less than 1.0%. Oxyquinoline is metabolized and excreted in the urine as glucuronides. The acute oral LD50 toxicity in rats was 1.2 g/kg. In subchronic studies, no deaths occurred in male and female rats at 5 doses up to 12,000 ppm or in male and female mice up to doses of 6000 ppm. Solid 100% Oxyquinoline was mildly irritating to rabbit skin and a 100 mg dose of Oxyquinoline was only slightly irritating to the eye. No sensitization test data were available for either of these cosmetic ingredients. Oxyquinoline and Oxyquinoline Sulfate were mutagenic when assayed using the Ames procedure with metabolic activation. Mutagenic activity was also demonstrated in the mouse lymphoma assay. Oxyquinoline was noncarcinogenic in several oral rodent feeding studies. The data from this negative oral carcinogenic assay were judged to be insufficient to evaluate the safety of use of Oxyquinoline and Oxyquinoline Sulfate when cosmetic products containing these ingredients are applied to the skin. It is concluded that the available carcinogenicity and sensitization test data are insufficient to support a conclusion on the safety of Oxyquinoline and Oxyquinoline Sulfate as used in cosmetic products.

scholarly journals 1 Final Report on the Safety Assessment of Candelilla Wax, Carnauba Wax, Japan Wax, and Beeswax

1984 ◽  
Vol 3 (3) ◽  
pp. 1-41 ◽  
Keyword(s):  
Test Data ◽  
Safety Assessment ◽  
Clinical Test ◽  
Final Report ◽  
Carnauba Wax ◽  
Candelilla Wax ◽  
Toxicological Test

Toxicological test data on four waxes-Candelilla, Carnauba, Japan, and Beeswax, singularly and in combination are presented. On the basis of the documented animal and clinical test data, it is concluded that these waxes are safe for cosmetic use.

scholarly journals Prediction of the Ultimate Strength of Notched and Unnotched IM7/977-3 Laminated Composites Using a Micromechanics Approach

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3491
Author(s):  
Manzar Masud ◽  
Moosa S. M. Al Kharusi ◽  
Muhammad Umair Ali ◽  
Aamir Mubashar ◽  
Shaik Javeed Hussain ◽  
...  
Keyword(s):  
Ultimate Strength ◽  
Test Data ◽  
Experimental Test ◽  
Laminated Composites ◽  
Compressive Load ◽  
Failure Criteria ◽  
Analysis Technique ◽  
Proposed Model ◽  
Tension And Compression ◽  
Failure Loads

This paper proposes a multi-scale analysis technique based on the micromechanics of failure (MMF) to predict and investigate the damage progression and ultimate strength at failure of laminated composites. A lamina’s representative volume element (RVE) is developed to predict and calculate constituent stresses. Damages that occurred in the constituents are calculated using separate failure criteria for both fiber and matrix. Subsequently, the volume-based damage homogenization technique is utilized to prevent the localization of damage throughout the total matrix zone. The proposed multiscale analysis procedure is then used to investigate the notched and unnotched behavior of three multi-directional composite layups, [30, 60, 90, −60, 30]2s, [0, 45, 90, −45]2s, and [60, 0, −60]3s, subjected to static tension and compression loading. The specimen is fabricated from unidirectionally reinforced composite (IM7/977-3). The prediction of ultimate strength at failure and equivalent stiffness are then benchmarked against the experimental test data. The comparative analysis with various failure models is also carried out to validate the proposed model. MMF demonstrated the capability to correctly predict the ultimate strength at failure for a range of multidirectional composites laminates under tensile and compressive load. The numerically predicted findings revealed a good agreement with the experimental test data. Out of the three investigated composite layups, the simulated results for the quasi-isotropic [0, 45, 90, −45]2S layup agreed extremely well with the experimental results with all the percentage errors within 10% of the measured failure loads.

Final Report on the Safety Assessment of Adipic Acid Dihydrazide

1994 ◽  
Vol 13 (3) ◽  
pp. 154-156 ◽  
Keyword(s):  
Test Data ◽  
Adipic Acid ◽  
Final Report ◽  
Cosmetic Products ◽  
Uv Spectrum ◽  
Ocular Irritation ◽  
Dermal Irritation ◽  
Safety Test ◽  
Cosmetic Formulations

Adipic Acid Dihydrazide has been used as a chemical additive in a variety of cosmetic products. The ingredient was previously reported to be used; however, there are no reported uses of Adipic Acid Dihydrazide during 1992. The available safety test data were insufficient to judge the safety of use of Adipic Acid Dihydrazide in cosmetic products. The types of data required before an evaluation on the safety of use of this cosmetic ingredient include: metabolism (stability of compound in vivo, with respect to hydrolysis to hydrazine); stability and impurities (specifically, data on hydrazine content is necessary); concentration of use in cosmetic formulations. If the interpretation of the preceding requested data indicates that this ingredient could be safely used in cosmetic formulations, the following additional safety test data must be available and evaluated before it can be determined whether this compound may be safely used in cosmetic products. The needed data include: chemistry (including pH, method of manufacture, and UV spectrum); ocular irritation; dermal irritation; dermal sensitization; dermal photosensitization (only if the compound absorbs in the UV spectrum); 28-day dermal toxicity; genotoxicity (at least two assays); carcinogenicity may be requested if genotoxicity assays are positive.

Prediction of Mechanical Behavior of Concrete Filled Steel Tube Structure Using Artificial Neural Network

2013 ◽  
Vol 368-370 ◽  
pp. 1095-1098 ◽  
Author(s):  
Ying Wang ◽  
Zhi Quan Liu ◽  
Ming Zhang
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Prediction Model ◽  
Test Data ◽  
Experimental Test ◽  
Steel Tube ◽  
Concrete Filled Steel Tube ◽  
Strain Relationship ◽  
Structural Parts ◽  
Relationship Of

Artificial neural network (ANN) is applied to predict load-strain relationship of concrete filled steel tube (CFT) structural parts. An ANN prediction model, which is able to predict load-strain relationship of CFT structural parts with different dimensions and parameters, is made through training the ANN prediction model with the experimental test data. Furthermore, the prediction data and experimental test data are compared. The result shows that the combination of several characteristic parameters of CFT structural parts and ANN prediction model to predict load-strain relationship of CFT structural parts are reliable and feasible. The ANN prediction model has simple, convenience and time-saving merits.

8 Final Report on the Safety Assessment of Sodium Cetearyl Sulfate

1992 ◽  
Vol 11 (1) ◽  
pp. 145-155 ◽  
Keyword(s):  
Test Data ◽  
Safety Assessment ◽  
Sodium Lauryl Sulfate ◽  
Safety Evaluation ◽  
Final Report ◽  
Lauryl Sulfate ◽  
Chemical Similarity ◽  
Ocular Irritation ◽  
Safety Test ◽  
Cosmetic Ingredients

Sodium Cetearyl Sulfate is the sodium salt of a mixture of cetyl and stearyl sulfate which is used as a surfactant and cleansing agent in cosmetics at concentrations ranging from ≥ 0.1 to 25.0%. The LD50 was not achieved in two studies in which rats received a single oral dose of 5.0 ml/kg. In ocular irritation tests, 20.0% aqueous Sodium Cetearyl Sulfate was not irritating to the eyes of rabbits. Twenty percent Sodium Cetearyl Sulfate was not irritating to the skin of rabbits. In a guinea pig sensitization study, Sodium Cetearyl Sulfate was not a sensitizer. Sodium Cetearyl Sulfate is less irritating to the skin than Sodium Lauryl Sulfate, whose safety test data are summarized in the report. Due to the chemical similarity of these two cosmetic ingredients, the safety test data on Sodium Lauryl Sulfate was considered to be applicable to the safety evaluation of this ingredient. On the basis of the animal and clinical data on Sodium Cetearyl Sulfate and Sodium Lauryl Sulfate as presented in the report, it is concluded that Sodium Cetearyl Sulfate is safe as a cosmetic ingredient in the present practices of use and concentration.

Sign in / Sign up

Export Citation Format

Share Document