scholarly journals Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

2014 ◽  
Author(s):  
Peter O'Neill ◽  
◽  
Jennifer Anderson
Keyword(s):  
Dna Damage ◽  
Growth Factors ◽  
Systems Biology ◽  
Cross Talk ◽  
Dose Response ◽  
Low Dose ◽  
Tissue Growth ◽  
Atm Signaling

scholarly journals Dose-response analysis of bromate-induced DNA damage and mutagenicity is consistent with low-dose linear, nonthreshold processes

2012 ◽  
Vol 54 (1) ◽  
pp. 19-35 ◽  
Author(s):  
Maria A. Spassova ◽  
David J. Miller ◽  
David A. Eastmond ◽  
Nadejda S. Nikolova ◽  
Suryanarayana V. Vulimiri ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dose Response ◽  
Low Dose ◽  
Response Analysis

scholarly journals Rationale and utility of sub-therapeutic/low dose cytokines and growth factors in dermatology: an overview

2020 ◽  
Vol 23 (5) ◽  
pp. 293-302
Author(s):  
I. Podder ◽  
R. Sadoughifar ◽  
M. Goldust ◽  
Lotti Torello
Keyword(s):  
Atopic Dermatitis ◽  
Growth Factors ◽  
Immune System ◽  
Cross Talk ◽  
Low Dose ◽  
Psoriasis Vulgaris ◽  
Cellular Responses ◽  
Autoimmune Disorders ◽  
Signal Molecules ◽  
External Stimuli

The review presents data on a new low-dose medicine approach in several dermatoses such as psoriasis, atopic dermatitis and vitiligo based on the signaling molecules, which are responsible for the cross-talk between the psychoneuroendocrine and immune system and regulate the cellular responses to internal and external stimuli. An imbalance of specific signal molecules leads to inflammatory, allergic and autoimmune disorders. The mechanisms of signal molecules action and aspects of Psycho-neuro-endocrine-immunology are presented. Recent studies on efficacy of low-dose medicine along with recommended strategies in psoriasis vulgaris (IL-4, IL-10, IL-11), atopic dermatitis (IL-12, IFN), and vitiligo (IL-10, IL-4, anti-IL-1, b-FGF) are observed.

scholarly journals Growth factors in the regulation of reparative response in the presence of peritoneal damage

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Irina A. Shurygina ◽  
Мichael G. Shurygin ◽  
Lubov V. Rodionova ◽  
Nataliya I. Ayushinova
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Extended Period ◽  
Tissue Growth ◽  
Tissue Response ◽  
Heparin Binding ◽  
Lower Quadrant ◽  
Male Wistar Rats ◽  
The Right ◽  
Endothelial Growth Factor

AbstractObjectivesTo study the expression of growth factors in the regulation of tissue repair after peritoneal damage tissue response to peritoneal damage.MethodsExperimental study in 35 male Wistar rats determining the evolution over time of the tissue response to aseptic peritoneal damage. A standardized bowel and peritoneal lesions were created in the right lower quadrant by laparotomy. Then, tissular expression of growth factors was evaluated by multiplex polymerase chain reaction at seven timepoints between 6 h and 30 days, postoperatively.ResultsTissular responses of granulocyte-stimulating factors (Csf2, Csf3), connective tissue growth factor (Ctgf), epidermal growth factors and receptor (Egf, Egfr), fibroblast growth factors (Fgf2, 7 and 10), heparin binding EGF-like growth factor (Hbegf), hepatocyte growth factor (Hgf), insulin-like growth factor-1 (Igf1), mitogenic transforming growth factors (Tgfa, Tgfb1, Tgfbr3), and vascular endothelial growth factor A (Vegfa) were biphasic with a first expression peak at day 3, followed by a more pronounced peak at day 14.ConclusionsWe observed a long-lasting, widespread response of tissular growth factors for at least two weeks after peritoneal damage. To be clinically effective, the prophylaxis of postoperative adhesions might be needed for an extended period of time.

scholarly journals Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Ning Liu ◽  
Yang Peng ◽  
Xinguang Zhong ◽  
Zheng Ma ◽  
Suiping He ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Dose Response ◽  
Low Dose ◽  
Linear Trend ◽  
Hematological Parameters ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Spline Models ◽  
Cumulative Radiation Dose

Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (Ptrend = 0.258), the non-linear trend tested was statistically significant (Pnon-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.

Defining hormesis: the necessary tool to clarify experimentally the low dose–response relationship

2002 ◽  
Vol 21 (2) ◽  
pp. 103-104 ◽  
Author(s):  
G Carelli ◽  
I Iavicoli
Keyword(s):  
Dose Response ◽  
Low Dose ◽  
Experimental Models ◽  
Assessment Criteria ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Specific Context ◽  
Definition Of ◽  
Time Specific ◽  
Made In

The authors comment on Calabrese and Baldwin's paper ‘Defining Hormesis’, which, to date, is the first attempt to provide a definition of hormesis that goes beyond the different interpretations of this phenomenon reported in the literature. While appreciating the effort made in this study to place hormesis in a general and at the same time specific context, the authors believe some clarifications are needed as regards the quantitative features of this phenomenon. In this connection, they speculate on whether Calabrese and Baldwin think it appropriate to include hormesis assessment criteria in the document, referring in particular to those reported in a previous paper. The authors share Calabrese and Baldwin's conclusion that future experimental models designed to study hormetic phenomena must necessarily include the time factor, which not only guarantees this phenomenon will be detected, but is also able to detect the specific type of hormesis.

scholarly journals Imaging flow cytometry as a sensitive tool to detect low-dose-induced DNA damage by analyzing 53BP1 and γH2AX foci in human lymphocytes

2015 ◽  
Vol 87 (12) ◽  
pp. 1070-1078 ◽  
Author(s):  
Matus Durdik ◽  
Pavol Kosik ◽  
Jan Gursky ◽  
Lenka Vokalova ◽  
Eva Markova ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Dna Damage ◽  
Low Dose ◽  
Human Lymphocytes ◽  
Imaging Flow Cytometry ◽  
Γh2ax Foci ◽  
Sensitive Tool

The Dose Response of Chromosome Aberrations in Human Lymphocytes InducedIn Vitroby Very Low-Dose γ Rays

2011 ◽  
Vol 175 (2) ◽  
pp. 208-213 ◽  
Author(s):  
Toshiyasu Iwasaki ◽  
Yoshio Takashima ◽  
Toshikazu Suzuki ◽  
Mitsuaki A. Yoshida ◽  
Isamu Hayata
Keyword(s):  
Dose Response ◽  
Chromosome Aberrations ◽  
Low Dose ◽  
Human Lymphocytes ◽  
Γ Rays
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