scholarly journals Developing a New Accelerator Mass Spectrometry Assay for Quantitation of Platinum DNA Adducts for Response to Platinum-Based Chemotherapy

2008 ◽  
Author(s):  
P Henderson
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry ◽  
Platinum Based Chemotherapy ◽  
Mass Spectrometry Assay

scholarly journals Genotoxicity Study on Nicotine and Nicotine-Derived Nitrosamine by Accelerator Mass Spectrometry

Radiocarbon ◽  
1996 ◽  
Vol 38 (2) ◽  
pp. 347-353 ◽  
Author(s):  
X. S. Li ◽  
H. F. Wang ◽  
J. Y. Shi ◽  
X. Y. Wang ◽  
Y. F. Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry ◽  
Chemical Speciation ◽  
Animal Experiments ◽  
Tobacco Consumption ◽  
Carcinogenic Risk ◽  
Dna Adduction ◽  
Carcinogenic Risk Assessment ◽  
Potential Carcinogen

We have studied DNA adduction with 14C-labeled nicotine and nicotine-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by accelerator mass spectrometry (AMS) in mouse liver at doses equivalent to low-level exposure of humans. The dose ranges of nicotine and NNK administered were from 0.4 μg to 4.0×102 μg kg b.w.-1, and from 0.1 μg to 2.0×104 μg kg b.w.-1, respectively. In the exposure of mice to either nicotine or NNK, the number of DNA adducts increased linearly with increasing dose. The detection limit of DNA adducts was 1 adduct per 1011 nucleotide molecules. This limit is 1–4 orders of magnitude lower than that of other techniques used for quantification of DNA adducts. The results of our animal experiments enabled us to speculate that nicotine is a potential carcinogen. According to the procedure for 14C-labeled-NNK synthesis, we discuss the ultimate chemical speciation of NNK bound to DNA. From the animal tests we derived a directly perceivable relation between tobacco consumption and DNA adduction as the carcinogenic risk assessment.

Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry

2005 ◽  
Vol 20 (4) ◽  
pp. 397-401 ◽  
Author(s):  
H. F. Du ◽  
L. H. Xu ◽  
H. F. Wang ◽  
Y. F. Liu ◽  
X. Y. Tang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry

scholarly journals Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

2008 ◽  
Vol 36 (16) ◽  
pp. e100-e100 ◽  
Author(s):  
K. E. Coldwell ◽  
S. M. Cutts ◽  
T. J. Ognibene ◽  
P. T. Henderson ◽  
D. R. Phillips
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry

Quantitation of benzo[a]pyrene-DNA adducts by postlabeling with 14C-acetic anhydride and accelerator mass spectrometry

2000 ◽  
Vol 126 (3) ◽  
pp. 171-183 ◽  
Author(s):  
Radoslav Goldman ◽  
Billy W Day ◽  
Tonya A Carver ◽  
Robert J Mauthe ◽  
Kenneth W Turteltaub ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Acetic Anhydride ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry

Detection of Adriamycin-DNA Adducts by Accelerator Mass Spectrometry

2009 ◽  
pp. 103-118 ◽  
Author(s):  
Kate Coldwell ◽  
Suzanne M. Cutts ◽  
Ted J. Ognibene ◽  
Paul T. Henderson ◽  
Don R. Phillips
Keyword(s):  
Mass Spectrometry ◽  
Dna Adducts ◽  
Accelerator Mass Spectrometry
Sign in / Sign up

Export Citation Format

Share Document