scholarly journals Extending and automating a Systems-Theoretic hazard analysis for requirements generation and analysis.

2012 ◽  
Author(s):  
John Thomas
Keyword(s):  
Hazard Analysis ◽  
Requirements Generation

scholarly journals A comparison of hazard analysis methods capability for safety requirements generation

2021 ◽  
pp. 1748006X2110034
Author(s):  
Nanda Anugrah Zikrullah ◽  
Hyungju Kim ◽  
Meine JP van der Meulen ◽  
Gunleiv Skofteland ◽  
Mary Ann Lundteigen
Keyword(s):  
Process Analysis ◽  
Hazard Analysis ◽  
Functional Requirements ◽  
Critical System ◽  
Safety Requirements ◽  
Safety Critical System ◽  
Analysis Methods ◽  
Resilience Management ◽  
Requirements Generation ◽  
Software Intensive

A safety-critical system comprising several interacting and software-intensive systems must be carefully analyzed to detect whether new functional requirements are needed to ensure safety. This involves an analysis of the systemic properties of the system, which addresses the effect of the interaction between systems and system parts. The paper compares two hazard analysis methods, which are often considered well-suited for such software-intensive systems: the Functional Hazard Analysis (FHA) and Systems-Theoretic Process Analysis (STPA). The focus is on the selection and improvement of the best methods, based on the lesson learned from the comparison of FHA and STPA. The analyses cover the hazard analysis processes, systemic properties, and the criteria of requirements. The paper concludes that STPA is the better choice over FHA. Insights are obtained to align both STPA and FHA methods with the broader topic on risk management, that is, hazard analysis method improvement, cautionary thinking, uncertainty management, and resilience management.

Food Safety Security: A new Concept for Enhancing Food Safety Measures

2012 ◽  
Vol 82 (3) ◽  
pp. 216-222 ◽  
Author(s):  
Venkatesh Iyengar ◽  
Ibrahim Elmadfa
Keyword(s):  
Food Safety ◽  
Hazard Analysis ◽  
Warning System ◽  
Shared Responsibility ◽  
Fine Tuning ◽  
Strategic Action ◽  
Surveillance Network ◽  
Measurement Systems ◽  
Critical Control Points ◽  
The Impact

The food safety security (FSS) concept is perceived as an early warning system for minimizing food safety (FS) breaches, and it functions in conjunction with existing FS measures. Essentially, the function of FS and FSS measures can be visualized in two parts: (i) the FS preventive measures as actions taken at the stem level, and (ii) the FSS interventions as actions taken at the root level, to enhance the impact of the implemented safety steps. In practice, along with FS, FSS also draws its support from (i) legislative directives and regulatory measures for enforcing verifiable, timely, and effective compliance; (ii) measurement systems in place for sustained quality assurance; and (iii) shared responsibility to ensure cohesion among all the stakeholders namely, policy makers, regulators, food producers, processors and distributors, and consumers. However, the functional framework of FSS differs from that of FS by way of: (i) retooling the vulnerable segments of the preventive features of existing FS measures; (ii) fine-tuning response systems to efficiently preempt the FS breaches; (iii) building a long-term nutrient and toxicant surveillance network based on validated measurement systems functioning in real time; (iv) focusing on crisp, clear, and correct communication that resonates among all the stakeholders; and (v) developing inter-disciplinary human resources to meet ever-increasing FS challenges. Important determinants of FSS include: (i) strengthening international dialogue for refining regulatory reforms and addressing emerging risks; (ii) developing innovative and strategic action points for intervention {in addition to Hazard Analysis and Critical Control Points (HACCP) procedures]; and (iii) introducing additional science-based tools such as metrology-based measurement systems.

PEMETAAN DAERAH RENTAN GEMPA BUMI SEBAGAI DASAR PERENCANAAN TATA RUANG DAN WILAYAH DI PROVINSI SULAWESI BARAT

KURVATEK ◽  
2017 ◽  
Vol 1 (2) ◽  
pp. 41-47
Author(s):  
Marinda noor Eva
Keyword(s):  
Seismic Hazard ◽  
Hazard Analysis ◽  
Probabilistic Seismic Hazard Analysis ◽  
Seismic Hazard Analysis ◽  
Probabilistic Seismic Hazard

Penelitian mengenai daerah rawan gempa bumi ini menggunakan Metode Probabilistic Seismic Hazard Analysis (PSHA) di Provinsi Sulawesi Barat, dengan tujuan untuk memetakan tingkat kerawanan bahaya gempa bumi di Kabupaten Mamasa. Penelitian ini menggunakan data kejadian gempa bumi di Pulau Sulawesi dan sekitarnya dari tahun 1900 – 2015. Hasil pengolahan PSHA menggunakan Software Ez-Frisk 7.52 yang menghasilkan nilai hazard di batuan dasar pada kondisi PGA (T = 0,0 sekon), dengan periode ulang 500 tahun dan 2500 tahun berkisar antara (149,54 – 439,45) gal dan (287,18 – 762,81) gal. Nilai hazard di batuan dasar dengan kondisi spektra T = 0,2 sekon untuk periode ulang 500 tahun dan 2500 tahun adalah (307,04 – 1010,90) gal dan (569,48 – 1849,78) gal. Nilai hazard di batuan dasar dengan kondisi spektra T = 1,0 sekon untuk periode ulang 500 tahun dan 2500 tahun diperoleh nilai (118,01 – 265,75) gal dan (223,74 – 510,92) gal. Berdasarkan analisis PSHA, nilai PGA di Provinsi Sulawesi Barat dominan dipengaruhi oleh sumber gempa sesar.

Agent-based approach for process hazard analysis

2014 ◽  
Author(s):  
Dong Gao ◽  
Xin Xu ◽  
Beike Zhang ◽  
Xin Ma
Keyword(s):  
Hazard Analysis ◽  
Agent Based

Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Hazard Analysis ◽  
Critical Role ◽  
Immunohistochemical Analysis ◽  
Lncap Cells ◽  
Cancer Specific Survival ◽  
High Gleason Score ◽  
Castrate Resistant ◽  
Transcription Factor 1

The androgen receptor (AR) plays a critical role in the development and the progression of prostate cancer. Alterations in theexpression of AR coregulators lead to AR hypersensitivity, which is one of the mechanisms underlying the progression ofprostate cancer into a castrate-resistant state. Octamer transcription factor 1 (Oct1) is a ubiquitous member of the POUhomeodomainfamily that functions as a coregulator of AR. In our study, the contribution of Oct1 to prostate cancerdevelopment was examined. Immunocytochemistry analysis showed that Oct1 is expressed in the nuclei of LNCaP cells.siRNA-mediated silencing of Oct1 expression inhibited LNCaP cell proliferation. Immunohistochemical analysis of Oct1expression in tumor specimens obtained from 102 patients with prostate cancer showed a positive correlation of Oct1immunoreactivity with a high Gleason score and AR immunoreactivity (p 5 0.0042 and p < 0.0001, respectively). Moreover,patients with high immunoreactivity of Oct1 showed a low cancer-specific survival rate, and those patients with highimmunoreactivities of both Oct1 and AR exhibited poorer cancer-specific prognosis. Multivariate hazard analysis revealed asignificant correlation between high Oct1 immunoreactivity and poor cancer-specific survival (p 5 0.012). These resultsdemonstrate that Oct1 can be a prognostic factor in prostate cancer as a coregulator of AR and may lead to the developmentof a new therapeutic intervention for prostate cancer.

PSHA software review based on the Monte Carlo method

2020 ◽  
pp. 14-24
Author(s):  
V.A. Mironov ◽  
S.A. Peretokin ◽  
K.V. Simonov
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Method ◽  
Seismic Hazard ◽  
Hazard Analysis ◽  
Software Review ◽  
Seismic Hazard Analysis ◽  
Probabilistic Seismic Hazard ◽  
Test Calculation ◽  
Seismic Surveys ◽  
The Monte Carlo Method

The article is a continuation of the software research to perform probabilistic seismic hazard analysis (PSHA) as one of the main stages in engineering seismic surveys. The article provides an overview of modern software for PSHA based on the Monte Carlo method, describes in detail the work of foreign programs OpenQuake Engine and EqHaz. A test calculation of seismic hazard was carried out to compare the functionality of domestic and foreign software.

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