scholarly journals [Bifunctional chelates of Rh-105, Au-199, and other metallic radionuclides as potential radiotherapeutic agents]

1991 ◽  
Author(s):  
Keyword(s):  
Bifunctional Chelates

Synthesis of (Pyridin-2-yl)hydrazine Conjugates as Bifunctional Chelates Using the Suzuki—Miyaura Reaction.

ChemInform ◽  
2003 ◽  
Vol 34 (46) ◽  
Author(s):  
Jeffrey B. Arterburn ◽  
Bj K. Bryant ◽  
DaJun Chen
Keyword(s):  
Bifunctional Chelates

Evaluation of novel bifunctional chelates for the development of Cu-64-based radiopharmaceuticals

2008 ◽  
Vol 35 (8) ◽  
pp. 875-882 ◽  
Author(s):  
Cara L. Ferreira ◽  
Donald T. Yapp ◽  
Eric Lamsa ◽  
Martin Gleave ◽  
Corinne Bensimon ◽  
...  
Keyword(s):  
Bifunctional Chelates

scholarly journals Isothiocyanate-Functionalized Bifunctional Chelates andfac-[MI(CO)3]+(M = Re,99mTc) Complexes for Targeting uPAR in Prostate Cancer

2015 ◽  
Vol 27 (1) ◽  
pp. 130-142 ◽  
Author(s):  
Benjamin B. Kasten ◽  
Xiaowei Ma ◽  
Kai Cheng ◽  
Lihong Bu ◽  
Winston S. Slocumb ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bifunctional Chelates

Direct Reductive Alkylation of Amino Acids: Synthesis of Bifunctional Chelates for Nuclear Imaging.

ChemInform ◽  
2005 ◽  
Vol 36 (1) ◽  
Author(s):  
Murali K. Levadala ◽  
Sangeeta Ray Banerjee ◽  
Kevin P. Maresca ◽  
John W. Babich ◽  
Jon Zubieta
Keyword(s):  
Amino Acids ◽  
Nuclear Imaging ◽  
Reductive Alkylation ◽  
Bifunctional Chelates

In Vivo Evaluation of Bismuth-Labeled Monoclonal Antibody Comparing DTPA-Derived Bifunctional Chelates

2001 ◽  
Vol 16 (2) ◽  
pp. 133-146 ◽  
Author(s):  
Diane E. Milenic ◽  
Mario Roselli ◽  
Saed Mirzadeh ◽  
C. Greg Pippin ◽  
Otto A. Gansow ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
In Vivo Evaluation ◽  
Bifunctional Chelates

Functionalization of porphyrins: towards the synthesis of bifunctional chelates for bismuth coordination

2010 ◽  
Vol 14 (05) ◽  
pp. 412-420 ◽  
Author(s):  
Zakaria Halime ◽  
Sébatien Balieu ◽  
Btissam Najjari ◽  
Mohammed Lachkar ◽  
Thierry Roisnel ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethyl Ester ◽  
Functional Group ◽  
Acid Ethyl Ester ◽  
Phenyl Group ◽  
Ester Group ◽  
Reactive Functional Group ◽  
Amine Function ◽  
Electron Withdrawing Group ◽  
Bifunctional Chelates

We report the condensation of 3-chloromethyl-benzoyl chloride with two atropisomers ααββ and αβαβ of meso-5,10,15,20-tetrakis-(2-amino)phenylporphyrin (TAPP), followed by the reaction of the anion of either cyano-acetic acid ethyl ester or (4-nitro-phenyl)-acetic acid ethyl ester to prepare various pre-organized strapped porphyrins. These two reagents were selected as both allow the easy formation of the anion in the α position of the ester group while their electron-withdrawing group (EWG) can be further transformed in a reactive functional group. In the ααββ series, this reaction leads to three isomeric porphyrins differing only by the location of their ethoxycarbonyl groups, oriented either towards the center of the porphyrin or maintained outside of the cavity. In the αβαβ series, as expected, a single porphyrin is obtained in which both straps bear an ethoxycarbonyl group, precursor of a hanging carboxylic function and a cyano or a 4-nitro-phenyl group, which can be reduced to an amine function, suitable for the coupling on a biomolecule.

Sign in / Sign up

Export Citation Format

Share Document