scholarly journals Coprocessing through fundamental and mechanistic studies in hydrogen transfer and catalysis. Quarterly report, March 28, 1992--June 30, 1992

1992 ◽  
Author(s):  
C.W. Curtis
Keyword(s):  
Hydrogen Transfer ◽  
Mechanistic Studies

scholarly journals Intermolecular Diastereoselective Annulation of Azaarenes into Fused N-heterocycles by Ru(II) Reductive Catalysis

2021 ◽  
Author(s):  
He Zhao ◽  
Yang Wu ◽  
Chenggang Ci ◽  
Zhenda Tan ◽  
Jian Yang ◽  
...  
Keyword(s):  
Building Block ◽  
Transfer Rate ◽  
Hydrogen Transfer ◽  
Functional Group ◽  
Critical Role ◽  
Hydride Transfer ◽  
Mechanistic Studies ◽  
Mild Conditions ◽  
Excellent Selectivity ◽  
Coupling Sequence

Abstract Despite the important advances in azaaryl C−H activation/functionalization, reductive functionalization of ubiquitously distributed but weakly reactive azaarenes remains to date a challenge. Herein, by a strategy incorporating a tandem coupling sequence into the reduction of azaarenes, we present a dearomative annulation of azaarenes into promising fused syn-N-heterocycles by combination with a large variety of aniline derivatives and paraformaldehyde under ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in azaarenes, paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemo-selectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions.

Synthetic Scope and Mechanistic Studies of Ru(OH)x/Al2O3-Catalyzed Heterogeneous Hydrogen-Transfer Reactions

2005 ◽  
Vol 11 (22) ◽  
pp. 6574-6582 ◽  
Author(s):  
Kazuya Yamaguchi ◽  
Takeshi Koike ◽  
Miyuki Kotani ◽  
Mitsunori Matsushita ◽  
Satoshi Shinachi ◽  
...  
Keyword(s):  
Hydrogen Transfer ◽  
Transfer Reactions ◽  
Mechanistic Studies ◽  
Hydrogen Transfer Reactions

Ruthenium xantphos complexes in hydrogen transfer processes: reactivity and mechanistic studies

2009 ◽  
pp. 716-722 ◽  
Author(s):  
Araminta E. W. Ledger ◽  
Paul A. Slatford ◽  
John P. Lowe ◽  
Mary F. Mahon ◽  
Michael K. Whittlesey ◽  
...  
Keyword(s):  
Hydrogen Transfer ◽  
Mechanistic Studies ◽  
Transfer Processes

scholarly journals Enantioselective Addition of Pyrazoles to Dienes

2021 ◽  
Author(s):  
Alexander Y. Jiu ◽  
Hannah Slocumb ◽  
Charles Yeung ◽  
Xiaohui Yang ◽  
Vy M. Dong
Keyword(s):  
Functional Groups ◽  
Hydrogen Transfer ◽  
Mechanistic Studies ◽  
Enantioselective Addition

We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd(0)-catalyzed ligand-to?ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and provides a breakthrough in hydrofunctionalization of dienes. <br>

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