scholarly journals Hematologic and Body Fluid Changes during Simulated High Altitude Exposure in Naproxen-Treated Rats.

1996 ◽  
Vol 46 (1) ◽  
pp. 67-73 ◽  
Author(s):  
H.M. BISWARS ◽  
R.C. SAHA ◽  
N.M. BISWAS
Keyword(s):  
High Altitude ◽  
Body Fluid ◽  
Altitude Exposure ◽  
Simulated High Altitude

Altitude-induced erythrocytic 2,3-DPG and hemoglobin changes in rats of various ages

1975 ◽  
Vol 39 (2) ◽  
pp. 258-261 ◽  
Author(s):  
L. G. Martin ◽  
J. M. Connors ◽  
J. J. McGrath ◽  
J. Freeman
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Age Groups ◽  
Altitude Exposure ◽  
Simulated High Altitude ◽  
Erythropoietic Response ◽  
2,3 Dpg

Rats of various ages (2, 12, 24, and 40 mo of age) were exposed for 4 wk to either a simulated high altitude of 23,000 ft or to a Peoria, Ill., altitude of 650 ft above sea level. Hematocrit ratios, hemoglobin, and erythrocytic 2,3-diphospho-glycerate (2,3-DPG) concentrations were measured. Hematocrit and hemoglobin determinations revealed a decrease in erythrocytic content with increasing age, and the augmented erythropoietic response was seen in all age groups of animals as a result of altitude exposure. The maximal erythrocytic content of hemoglobin in the 40-mo-old animals was significantly lower than that of all other age groups. Erythrocytic 2,3-DPG levels were significantly changed by aging alone. In the 40-mo-old group there was a 35% increase over the next highest sea-level value. However, while erythrocytic 2,3-DPG content increased significantly in all other age groups following altitude exposure, it decreased 46% in the 40-mo-old group.

Simulated High Altitude Exposure for Heart Failure Patients

2010 ◽  
Vol 16 (8) ◽  
pp. S104
Author(s):  
Philip Formica ◽  
Auris Browne ◽  
Simon Maybaum
Keyword(s):  
Heart Failure ◽  
High Altitude ◽  
Heart Failure Patients ◽  
Altitude Exposure ◽  
Simulated High Altitude

Body fluid and hematologic changes in the toad exposed to 48 h of simulated high altitude

1981 ◽  
Vol 51 (4) ◽  
pp. 794-797 ◽  
Author(s):  
H. M. Biswas ◽  
P. B. Patra ◽  
M. C. Boral
Keyword(s):  
High Altitude ◽  
Plasma Volume ◽  
Body Fluid ◽  
Extracellular Fluid ◽  
Control Group ◽  
Bufo Melanostictus ◽  
Simulated High Altitude ◽  
Volume Blood ◽  
Total Body ◽  
Toad Bufo

Body fluid and hematologic changes were found in three groups of adult male toads that had been exposed to 48 h of continuous simulated altitudes of 12,000, 18,000, and 24,000 ft, respectively. Erythrocyte counts and hematocrit ratios were increased significantly in all the high-altitude-exposed animals compared with the control group of animals kept at sea level, whereas the hemoglobin concentrations were significantly increased only in the 18,000- and 24,000-ft-exposed animals. Exposure to high altitude generally caused a reduction of plasma volume, blood volume, extracellular fluid volume, and total body water. These reductions were markedly lower in the animals exposed to 24,000 ft. These simulated high-altitude effects on body fluids and hematology in the toad (Bufo melanostictus) were compared with those of the rat, birds, and humans acutely acutely exposed at various high altitudes and were found to be qualitatively similar.

Systemic vascular reactivity during high-altitude pregnancy

1990 ◽  
Vol 69 (1) ◽  
pp. 201-206 ◽  
Author(s):  
G. L. Harrison ◽  
L. G. Moore
Keyword(s):  
High Altitude ◽  
Guinea Pigs ◽  
Vascular Reactivity ◽  
Prostaglandin Synthesis ◽  
Base Line ◽  
Synthesis Inhibitor ◽  
Altitude Exposure ◽  
Simulated High Altitude ◽  
Prostaglandin Synthesis Inhibitor ◽  
Low Altitude

There is an increased incidence of preeclampsia at high compared with low altitude. Increased vasoreactivity, possibly due to a deficiency of vasodilator prostaglandins, is thought to contribute to the etiology of preeclampsia. We sought to determine whether high-altitude exposure increased systemic vascular reactivity during pregnancy. We measured systemic vascular reactivity and contractile sensitivity of isolated aortic rings from pregnant and nonpregnant guinea pigs kept for 6 wk at either simulated high altitude (3,900 m) or low altitude (1,600 m). We found that pregnancy at high compared with low altitude increased baseline systemic vascular resistance (SVR) but not the SVR response to angiotensin II in awake unstressed guinea pigs. Contractile sensitivity to norepinephrine was also increased in aortic rings isolated from high-altitude compared with low-altitude pregnant animals. Meclofenamate, a prostaglandin synthesis inhibitor, did not equalize vasoreactivity in the high- and low-altitude pregnant guinea pigs or in their isolated aortic rings. We concluded that pregnancy at high compared with low altitude increased base-line SVR and aortic contractile sensitivity but that mechanisms other than decreased vasodilator prostaglandin production were responsible.

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