scholarly journals Proximal Tubular Cell Alkalinization Induced by Na+-Glucose Cotransport.

1995 ◽  
Vol 45 (5) ◽  
pp. 785-799 ◽  
Author(s):  
Nobuko HAGIWARA ◽  
Takahiro KUBOTA ◽  
Manabu KUBOKAWA ◽  
Mamoru FUJIMOTO
Keyword(s):  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular

scholarly journals Sex Differences in Renal Proximal Tubular Cell Homeostasis

2016 ◽  
Vol 27 (10) ◽  
pp. 3051-3062 ◽  
Author(s):  
Thomas Seppi ◽  
Sinikka Prajczer ◽  
Maria-Magdalena Dörler ◽  
Oliver Eiter ◽  
Daniel Hekl ◽  
...  
Keyword(s):  
Sex Differences ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Cell Homeostasis ◽  
Renal Proximal Tubular Cell ◽  
Proximal Tubular ◽  
Renal Proximal Tubular

Interaction of insulin with the renal proximal tubular cell

1985 ◽  
Vol 249 (1) ◽  
pp. F1-F11 ◽  
Author(s):  
M. R. Hammerman
Keyword(s):  
Basolateral Membrane ◽  
Tubular Epithelial Cell ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Factor Ii ◽  
Renal Proximal Tubular Cell ◽  
Proximal Tubular ◽  
Hormonal Action ◽  
Specific Receptors ◽  
Renal Proximal Tubular

Insulin is known to regulate both metabolic and transport functions in the renal proximal tubule. Insulin present in plasma and in glomerular ultrafiltrate is known to be degraded at this nephron site. This paper summarizes what is known about these processes and about the mechanisms by which the actions of insulin and the degradation of insulin are effected in the proximal tubular epithelial cell. Recent studies have characterized the binding of insulin to specific receptors present in the proximal tubular basolateral membrane. Binding of insulin to its receptor in this membrane is thought to initiate events that lead to the phosphorylation of that receptor. Such insulin-stimulated phosphorylation may mediate hormonal action. A possible role for insulin-like growth factor II in the modulation of the actions of insulin has been suggested by observations in the kidney and in nonrenal cells. These findings are integrated into a model characterizing the nature of the interaction of insulin with the renal proximal tubular cell.

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