scholarly journals Outward currents through the inwardly rectifying potassium channel of guinea-pig ventricular cells.

1988 ◽  
Vol 38 (1) ◽  
pp. 77-91 ◽  
Author(s):  
Akihiro SAIGUSA ◽  
Hiroko MATSUDA
Keyword(s):  
Guinea Pig ◽  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Ventricular Cells ◽  
Outward Currents ◽  
Inwardly Rectifying

scholarly journals Involvement of A pertussis Toxin Sensitive G-Protein in the Inhibition of Inwardly Rectifying K+Currents by Platelet-Activating Factor in Guinea-Pig Atrial Cardiomyocytes

1994 ◽  
Vol 3 (1) ◽  
pp. 45-51
Author(s):  
M. Gollasch ◽  
T. Kleppisch ◽  
D. Krautwurst ◽  
D. Lewinsohn ◽  
J. Hescheler
Keyword(s):  
Cyclic Amp ◽  
Guinea Pig ◽  
G Protein ◽  
Pertussis Toxin ◽  
Platelet Activating Factor ◽  
Resting Membrane Potential ◽  
Patch Clamp Technique ◽  
Guinea Pig Heart ◽  
Ventricular Cells ◽  
Inwardly Rectifying

Platelet-activating factor (PAF) inhibits single inwardly rectifying K+channels in guinea-pig ventricular cells. There is currently little information as to the mechanism by which these channels are modulated. The effect of PAF on quasi steady-state inwardly rectifying K+currents (presumably of the IK1type) of auricular, atrial and ventricular cardiomyocytes from guinea-pig were studied. Applying the patch-clamp technique in the whole-cell configuration, PAF (10 nM) reduced the K+currents in all three cell types. The inhibitory effect of PAF occurred within seconds and was reversible upon wash-out. It was almost completely abolished by the PAF receptor antagonist BN 50730. Intracellular infusion of atrial cells with guanine 5′-(β-thio)diphosphate (GDPS) or pretreatment of cells with pertussis toxin abolished the PAF dependent reduction of the currents. Neither extracellularly applied isoproterenol nor intracellularly applied adenosine 3′,5′-cyclic monophosphate (cyclic AMP) attenuated the PAF effect. In multicellular preparations of auricles, PAF (10 nM) induced arrhythmias. The arrhythmogenic activity was also reduced by BN 50730. The data indicate that activated PAF receptors inhibit inwardly rectifying K+currents via a pertussis toxin sensitive G-protein without involvement of a cyclic AMP-dependent step. Since IK1is a major component in stabilizing the resting membrane potential, the observed inhibition of this type of channel could play an important role in PAF dependent arrhythmogenesis in guinea-pig heart.

The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2→p11.1

1997 ◽  
Vol 79 (1-2) ◽  
pp. 85-87 ◽  
Author(s):  
N. Namba ◽  
R. Mori ◽  
H. Tanaka ◽  
I. Kondo ◽  
K. Narahara ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying

scholarly journals NovelKCNJ10Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1

2016 ◽  
Vol 291 (14) ◽  
pp. 7716-7726 ◽  
Author(s):  
Miguel P. Méndez-González ◽  
Yuriy V. Kucheryavykh ◽  
Astrid Zayas-Santiago ◽  
Wanda Vélez-Carrasco ◽  
Gerónimo Maldonado-Martínez ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying

scholarly journals Unconventional Role of the Inwardly Rectifying Potassium Channel Kir2.2 as a Constitutive Activator of RelA in Cancer

2012 ◽  
Vol 73 (3) ◽  
pp. 1056-1062 ◽  
Author(s):  
Inkyoung Lee ◽  
Sook-Ja Lee ◽  
Tong Mook Kang ◽  
Won Ki Kang ◽  
Chaehwa Park
Keyword(s):  
Potassium Channel ◽  
Inwardly Rectifying Potassium Channel ◽  
Inwardly Rectifying
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