scholarly journals Pressure-flow relationship of erythrocyte suspension in perfusion of Nuclepore membrane and red cell deformability.

1988 ◽  
Vol 38 (2) ◽  
pp. 145-158 ◽  
Author(s):  
Nobuhiro UYESAKA
Keyword(s):  
Red Cell ◽  
Erythrocyte Suspension ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Pressure Flow ◽  
Relationship Of ◽  
Nuclepore Membrane

scholarly journals Effect of Heinz Bodies on Red Cell Deformability

Blood ◽  
1972 ◽  
Vol 39 (5) ◽  
pp. 658-665 ◽  
Author(s):  
Alan Lubin ◽  
Jane F. Desforges
Keyword(s):  
Atp Depletion ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Heinz Body ◽  
Methemoglobin Formation ◽  
Filtration Properties ◽  
Relationship Of

Abstract Decreased deformability of acetylphenylhydrazine-treated erythrocytes, measured by in vitro filtration experiments, was found to parallel Heinz body formation. The decreased deformability seemed unrelated to methemoglobin formation, ATP depletion, red cell size, or membrane effect. Hemolysis of Heinz body erythrocytes occurred during filtration of severely damaged cells, in an all-or-none fashion. In mixtures, separation of untreated cells from Heinz body-containing erythrocytes could be accomplished by filtration. There may be a relationship of these filtration properties to intravascular, in vivo destruction of severely damaged cells in Heinz body anemias.

The Effects of Acute Smoking on Platelet Behaviour, Fibrinolysis and Haemorheology in Habitual Smokers

1984 ◽  
Vol 51 (01) ◽  
pp. 006-008 ◽  
Author(s):  
J J F Belch ◽  
B M McArdle ◽  
P Burns ◽  
G D O Lowe ◽  
C D Forbes
Keyword(s):  
Platelet Aggregation ◽  
Factor Viii ◽  
Plasminogen Activator ◽  
Arterial Thrombosis ◽  
Plasma Viscosity ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Cigarette Smokers ◽  
Smoking Group

SummaryThere is an increased frequency of arterial thrombosis in cigarette smokers. The changes in blood coagulation seen in these subjects have been studied by many workers but results have not always been in agreement. We wished to study the effects of acute .smoking on platelet behaviour, fibrinolysis and haemorheology in ten habitual smokers, and to compare these results with nonsmoking controls. Results show that the smoking group had higher plasma fibrinogen (p <0.04), lower plasminogen (p <0.02) and plasminogen activator (p <0.05), and higher plasma viscosity (p <0.003). The changes seen in cigarette smokers after smoking three cigarettes were an increase in the rate of platelet aggregation to ADP (p <0.02), an increase in α2M, (p <0.02), and factor VIII RAG (p <0.05). Plasma viscosity was decreased (p <0.02) as was red cell deformability (p >0.02).We confirm an increased tendency to hypercoagulability in smokers compared to controls which becomes more pronounced immediately after smoking three cigarettes.

An Assessment of Red Cell Deformability Using a Simple Filtration Method

1979 ◽  
Author(s):  
M Drummond ◽  
G Lowe ◽  
J Belch ◽  
C Forbes ◽  
J Barbenel
Keyword(s):  
Cell Count ◽  
Shear Viscosity ◽  
White Cell Count ◽  
White Cell ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Simple Method ◽  
Filtration Method ◽  
Significant Difference

We investigated the reproducibility and validity of a simple method of measuring red cell deformability (filtration of whole blood through 5 µ sieves) and its relationship to haematocrit, blood viscosity, fibrinogen, white cell count, sex and smoking. The mean coefficient of variation in normals was 3. 7%. Tanned red cells showed marked loss of deformability. Blood filtration rate correlated with haematocrit (r = 0. 99 on dilution of samples, r = 0. 7 in 120 normals and patients). After correction for haematocrit, deformability correlated with high shear viscosity, but not low shear viscosity, fibrinogen or white cell count. In 60 normals there was no significant difference between males and females, or smokers and non-smokers, but in 11 smokers there was an acute fall in deformability after smoking 3 cigarettes (p<0. 05). Reduced deformability was found in acute myocardial infarction (n = 15, p<0. 01) and chronic peripheral arterial disease (n = 15, p<0. 01). The technique is reproducible, detects rigid cells and appears useful in the study of vascular disease.

Increased prostacyclin metabolites and decreased red cell deformability in patients with systemic sclerosis and raynauds syndrome

1985 ◽  
Vol 17 (1) ◽  
pp. 1-9 ◽  
Author(s):  
J.J.F. Belch ◽  
M. McLaren ◽  
J. Anderson ◽  
G.D.O. Lowe ◽  
R.D. Sturrock ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability

Estimation of Red Cell Deformability Based on Flow Curve of Whole Blood in the Higher Shear Rate Range.

2001 ◽  
Vol 27 (2) ◽  
pp. 228-235
Author(s):  
Shinichi Ookawara ◽  
Akihisa Yano ◽  
Kohei Ogawa ◽  
Koichi Taniguchi
Keyword(s):  
Shear Rate ◽  
Whole Blood ◽  
Flow Curve ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Rate Range

Measurement of red cell deformability in plasma compared with buffer as suspending medium

1996 ◽  
Vol 16 (2) ◽  
pp. 151-163
Author(s):  
Philippine J.B. Bronkhorst ◽  
Gerard Berends ◽  
Max R. Bardeman ◽  
Evert Jan Nijhof ◽  
Jan J. Sixma
Keyword(s):  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability

scholarly journals Spherocytic Hemolytic Disease During Magnesium Deprivation in the Rat

Blood ◽  
1971 ◽  
Vol 38 (4) ◽  
pp. 468-478 ◽  
Author(s):  
MARTIN M. OKEN ◽  
MARSHALL A. LICHTMAN ◽  
DENIS R. MILLER ◽  
PIERRE LEBLOND
Keyword(s):  
Magnesium Deficiency ◽  
Lactate Production ◽  
Male Rats ◽  
Magnesium Concentration ◽  
Red Cell ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Intracellular Magnesium ◽  
Erythroid Hyperplasia

Abstract Young male rats (115 g) were maintained on diets containing 4-8 mg of magnesium per 100 g of diet for 12 wk. By 3 wk the characteristic features of magnesium deprivation developed, including decreased plasma and tissue magnesium concentration, growth retardation, ruffled fur, patchy dermatitis, irritability, hyperemia of acral parts, onychymegaly, and in the most severely restricted, premature death. By 7 wk of deprivation, evidence of a hemolytic state existed and thereafter reticulocytosis, spherocytosis, shortened 51Cr red cell survival, erythroid hyperplasia of the bone marrow, and mild anemia were present. Erythrocytes during magnesium deficiency were characterized by decreased intracellular magnesium, glucose utilization, lactate production, ATP and 2,3-DPG concentration. A progressive decrease in red cell deformability as measured by cell elastimetry occurred. The reduction in lactate production and in ATP concentration due to magnesium deficiency may be causal in the development of rigid spherocytes with shortened survival in vivo. In addition, the shape and deformability alteration of the red cell may be due to defective membrane construction in a magnesium-deficient environment.

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