scholarly journals Contribution of Ca2+-influx to generation of the transient inward current in guinea-pig ventricular muscles.

1987 ◽  
Vol 37 (3) ◽  
pp. 479-496 ◽  
Author(s):  
Masayasu HIRAOKA ◽  
Seiko KAWANO ◽  
Hiroyuki KINOSHITA
Keyword(s):  
Guinea Pig ◽  
Inward Current ◽  
Transient Inward Current

Caffeine-induced Ca2+ release activates Ca2+ extrusion via Na+-Ca2+ exchanger in cardiac myocytes

1989 ◽  
Vol 257 (1) ◽  
pp. C147-C152 ◽  
Author(s):  
G. Callewaert ◽  
L. Cleemann ◽  
M. Morad
Keyword(s):  
Guinea Pig ◽  
Cardiac Myocytes ◽  
Time Course ◽  
Ventricular Myocytes ◽  
Whole Cell ◽  
Inward Current ◽  
Fura 2 ◽  
Transient Inward Current ◽  
Inward Currents

Rapid application of caffeine in fura-2-dialyzed and whole cell-clamped rat and guinea pig ventricular myocytes activated reversibly large intracellular Ca2+ transients that accompanied Na+-dependent transient inward currents. Such transient inward currents had the same time course as the intracellular Ca2+ transient and were suppressed by Ni2+ and removal of extracellular Na+. Because Ca2+ release signals were not altered by addition of Ni2+ or removal of Na+, we concluded that the rise in intracellular Ca2+ concentration was necessary for the activation of the transient inward current. Thus the caffeine-induced transient inward current represents efflux of Ca2+ via the Na+-Ca2+ exchanger.

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