scholarly journals Sedative action of cholecystokinin octapeptide on behavioral excitation by thyrotropin releasing hormone and methamphetamine in the rat.

1982 ◽  
Vol 32 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Goro KATSUURA ◽  
Shinji ITOH
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Cholecystokinin Octapeptide ◽  
Releasing Hormone ◽  
Behavioral Excitation ◽  
Sedative Action

Thyrotropin-releasing hormone and amphetamine produce different patterns of behavioral excitation in rats

1981 ◽  
Vol 72 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Gregory N. Ervin ◽  
Stepanie A. Schmitz ◽  
Charles B. Nemeroff ◽  
Arthur J. Prange
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Behavioral Excitation

Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat

1989 ◽  
Vol 67 (3) ◽  
pp. 223-227 ◽  
Author(s):  
Akira Takashima ◽  
Shinji Itoh
Keyword(s):  
Spontaneous Activity ◽  
Open Field ◽  
Lateral Ventricle ◽  
Thyrotropin Releasing Hormone ◽  
Pharmacological Activities ◽  
Releasing Hormone ◽  
Field Situation ◽  
Small Doses ◽  
Sedative Action

It has been suggested that a nonapeptide called V-9-M (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) is produced by the processing of procholecystokinin. However, its physiological and pharmacological activities are not known. In the present study, synthetic V-9-M amide was injected into the lateral ventricle of the rat and its effects on general activities were observed. V-9-M caused a marked sedation; it suppressed spontaneous activity and hypermotility induced by thyrotropin-releasing hormone, methamphetamine, and apomorphine. Hypomotility induced by small doses of apomorphine was also decreased further. V-9-M caused hypothermia and prolonged the duration of pentobarbital-induced sleep, and it decreased locomotion in an open-field situation. However, V-9-M did not affect appetite in fasted rats.Key words: V-9-M, sedative action, hypothermia, sleep, appetite.

Effects of repetitive intravenous administration of thyrotropin-releasing hormone in normal subjects

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S68-S69
Author(s):  
M. LOSA ◽  
J. ALBA-LOPEZ ◽  
S. SOBIESCZCZYK ◽  
A. KÖNIG ◽  
C. R. PICKARDT ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Normal Subjects ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone
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