scholarly journals INCREASE IN THE BLOOD FLOW THROUGH BROWN ADIPOSE TISSUE IN RESPONSE TO COLD EXPOSURE AND NOREPINEPHRINE IN THE RAT

1967 ◽  
Vol 17 (5) ◽  
pp. 523-537 ◽  
Author(s):  
Akihiro KUROSHIMA ◽  
Norimichi KONNO ◽  
Shinji ITO
Keyword(s):  
Blood Flow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Brown Adipose ◽  
Flow Through

Involvement of nitric oxide in noradrenaline-induced increase in blood flow through brown adipose tissue

Life Sciences ◽  
1994 ◽  
Vol 54 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Tomoaki Nagashima ◽  
Hiroshi Ohinata ◽  
Akihiro Kuroshima
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Flow Through

scholarly journals Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat

1987 ◽  
Vol 243 (1) ◽  
pp. 281-284 ◽  
Author(s):  
J A Fernandez ◽  
T Mampel ◽  
F Villarroya ◽  
R Iglesias
Keyword(s):  
Blood Flow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Brown Fat ◽  
Direct Assessment ◽  
Brown Adipose ◽  
A Site

Tri-iodothyronine (T3)production by interscapular brown fat was studied by measurements of arterio-venous differences and blood flow across the tissue in rats exposed to the following situations: controls, acute cold, chronic cold and starvation. Results demonstrate that brown adipose tissue is a source of systemic T3 in the rat and that the T3 release is modulated according to the physiological situation of the animal: increased in cold exposure and inhibited in starvation.

Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis

1979 ◽  
Vol 57 (3) ◽  
pp. 257-270 ◽  
Author(s):  
David O. Foster ◽  
M. Lorraine Frydman
Keyword(s):  
Blood Flow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Tissue Distribution ◽  
Cold Exposure ◽  
Tissue Blood Flow ◽  
Anatomical Site ◽  
Nonshivering Thermogenesis ◽  
White Rats ◽  
Brown Adipose

Radioactive microspheres (12–16 μm) were used to measure cardiac output (CO), its fractional distribution, and hence tissue blood flow in conscious, warm-acclimated (WA) or cold-acclimated (CA) white rats exposed to temperatures of 25, 21, 6, −6, and −19 °C, the objective being to assess the tissue distribution of cold-induced thermogenesis. Total oxygen consumption was also measured. CA rats at 25 °C (CA25) had elevated arteriovenous shunting and other signs of heat stress. CA21 proved more suitable controls for the CA group. The cold-induced changes in blood flow to total skeletal muscle not involved in respiratory movements (M) and to the major masses of brown adipose tissue (BAT) were quantitatively very different in the two acclimation groups: in WA25 and CA21 flows to M were 31 (0.24 CO) and 27 (0.17 CO) mL/min, respectively, while flows to BAT were 2.1 and 9.7 mL/min; in WA−19 and CA−19 flows to M were 62 (0.32 CO) and 35 (0.16 CO) mL/min, respectively, while flows to BAT were 25 and 56 mL/min. In contrast, the effects of cold exposure on flows to other tissues and organs were remarkably alike in the two acclimation groups: e.g., flows to heart, ribcage, and diaphragm increased about three times between 25 and −19 °C, flow to the skin fell about 50%, and flows to the hepatosplanchnic region and kidneys were little or not at all affected by cold exposure. Estimates of the contributions of different tissues and organs to cold-induced thermogenesis were made on the basis of the relative changes in blood flow. It is concluded that BAT is by far the dominant anatomical site of the increased heat production of cold-exposed CA rats, and that nonshivering thermogenesis in BAT supplements considerably the shivering thermogenesis of cold-exposed WA rats.

Unilaterality of the sympathetic innervation of each pad of rat interscapular brown adipose tissue

1982 ◽  
Vol 60 (2) ◽  
pp. 107-113 ◽  
Author(s):  
David O. Foster ◽  
Florent Depocas ◽  
Gloria Zaror Behrens
Keyword(s):  
Blood Flow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Sympathetic Innervation ◽  
Maximum Increase ◽  
Interscapular Brown Adipose Tissue ◽  
Tissue Levels ◽  
Brown Adipose ◽  
Low Levels

The effects of sham, unilateral, and bilateral surgical denervation of rat interscapular brown adipose tissue (IBAT) on blood flow to the two IBAT pads of cold-acclimated (CA) rats during exposure of the animals to 22 or −6 °C and on the noradrenaline (NA) content and total dopamine-β-hydroxylase (DBH) (EC 1.14.17.1) activity of the pads in both warm-acclimated (WA) rats and CA rats were examined. Increase in IBAT blood flow upon cold exposure was taken as an index of sympathetically mediated calorigenesis in the tissue, and decreases in tissue levels of NA and DBH served as indices of the extent of destruction of the sympathetic innervation. At 24 h postsurgery, denervated pads of CA rats, whether from unilaterally or bilaterally denervated IBAT, had less than 3% of the NA, 40-44% of the DBH, and 0% of the 10-fold, cold-induced increase in blood flow measured in intact pads of CA rats with sham-operated or unilaterally denervated IBAT. IBAT bilaterally denervated for 24 h was as responsive in terms of its maximum increase in blood flow during infusion of CA rats with NA as intact IBAT. DBH in denervated pads of both WA rats and CA rats fell to 5% or less of control levels at 2 days postdenervation and remained at these low levels, as did NA, for at least 8 weeks. These results strongly support the longstanding but recently challenged hypothesis that each pad of rat IBAT is independently innervated by sympathetic fibers.

scholarly journals Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue

iScience ◽  
2021 ◽  
pp. 102434
Author(s):  
Winifred W. Yau ◽  
Kiraely Adam Wong ◽  
Jin Zhou ◽  
Nivetha Kanakaram Thimmukonda ◽  
Yajun Wu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Oxidation ◽  
Cold Exposure ◽  
Acid Oxidation ◽  
Brown Adipose ◽  
Mitochondrial Turnover

Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype

Metabolism ◽  
2021 ◽  
Vol 117 ◽  
pp. 154709 ◽  
Author(s):  
Tim Hollstein ◽  
Karyne Vinales ◽  
Kong Y. Chen ◽  
Aaron M. Cypess ◽  
Alessio Basolo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Thrifty Phenotype ◽  
Brown Adipose ◽  
Metabolic Feature ◽  
Brown Adipose Tissue Activity
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