scholarly journals Controversies Surrounding Omega-3 Fatty Acids and Prostate Cancer

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Xinchun Zhou ◽  
Akram Shalaby ◽  
Timothy C. Allen
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1616 ◽  
Author(s):  
Hanane Moussa ◽  
Molière Nguile-Makao ◽  
Karine Robitaille ◽  
Marie-Hélène Guertin ◽  
Janie Allaire ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Active Surveillance ◽  
Experimental Studies ◽  
Low Risk ◽  
Prostate Tissue ◽  
High Grade ◽  
Protective Effects ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and ω3 levels assessed in prostatic tissue, red blood cells (RBC), and diet. We conducted a validation cross-sectional study nested within a phase II clinical trial. We identified 157 men diagnosed with low-risk PCa who underwent a first active surveillance repeat prostate biopsy session. Fatty acid (FA) intake was assessed using a food frequency questionnaire and their levels measured in prostate tissue and RBC. Associations were evaluated using logistic regression. At first repeat biopsy session, 39 (25%) men had high-grade PCa (grade group ≥2). We found that high LCω3-eicosapentaenoic acid (EPA) level in prostate tissue (odds ratio (OR) 0.25; 95% (confidence interval (CI) 0.08–0.79; p-trend = 0.03) was associated with lower odds of high-grade PCa. Similar results were observed for LCω3 dietary intake (OR 0.30; 95% CI 0.11-0.83; p-trend = 0.02) but no association for RBC. LCω3-EPA levels in the target prostate tissue are inversely associated with high-grade PCa in men with low-risk PCa, supporting that prostate tissue FA, but not RBC FA, is a reliable biomarker of PCa risk.

scholarly journals Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells

2014 ◽  
Vol 352 (2) ◽  
pp. 380-394 ◽  
Author(s):  
Ze Liu ◽  
Mandi M. Hopkins ◽  
Zhihong Zhang ◽  
Chrystal B. Quisenberry ◽  
Louise C. Fix ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Growth Factor Signaling ◽  
Human Prostate Cancer ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Prostate Cancer Cells

scholarly journals Dietary Omega-6 and Omega-3 Fatty Acids and Prostate Cancer – Letter

2012 ◽  
Vol 5 (5) ◽  
pp. 798-798 ◽  
Author(s):  
Maria Azrad ◽  
Wendy Demark-Wahnefried
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 6

scholarly journals Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression during Active Surveillance

2014 ◽  
Vol 7 (7) ◽  
pp. 766-776 ◽  
Author(s):  
Xavier Moreel ◽  
Janie Allaire ◽  
Caroline Léger ◽  
André Caron ◽  
Marie-Ève Labonté ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Active Surveillance ◽  
Cancer Progression ◽  
Omega 3 Fatty Acids ◽  
Prostate Cancer Progression ◽  
Omega 3

scholarly journals Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression

The Prostate ◽  
2016 ◽  
Vol 76 (14) ◽  
pp. 1293-1302 ◽  
Author(s):  
Pei Liang ◽  
Susanne M. Henning ◽  
Shiruyeh Schokrpur ◽  
Lily Wu ◽  
Ngan Doan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Progression ◽  
Omega 3 Fatty Acids ◽  
Prostate Cancer Progression ◽  
Omega 3 ◽  
Tumor Associated Macrophages

What You Should Know About Omega-3 Fatty Acids and Prostate Cancer

2014 ◽  
Vol 11 (4) ◽  
pp. 476-478 ◽  
Author(s):  
Sidney J. Stohs ◽  
Kenneth Goldberg
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3
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