scholarly journals Noninvasive assessment of the patency of the previously occluded coronary artery following coronary thrombolysis in patients with acute myocardial infarction using serial changes in serum creatine kinase.

1989 ◽  
Vol 78 (3) ◽  
pp. 338-344
Author(s):  
Yoichi SATO ◽  
Katsuo KANMATSUSE ◽  
Ken NAGAO ◽  
Nagao KAJIWARA
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Coronary Artery ◽  
Serum Creatine Kinase ◽  
Coronary Thrombolysis ◽  
Noninvasive Assessment

heterogeneity of creatine kinase isoenzyme MM in serum in myocardial infarction: interconversion of the "normal" and "abnormal" sub-bands by glutathione

1990 ◽  
Vol 36 (5) ◽  
pp. 775-777 ◽  
Author(s):  
J Williams ◽  
K M Williams ◽  
T Marshall
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Reduced Glutathione ◽  
Serum Creatine Kinase ◽  
Final Concentration ◽  
Oxidized Glutathione ◽  
Creatine Kinase Isoenzyme ◽  
Sequence Of Events ◽  
Opposite Sequence

Abstract We used isoelectric focusing (IEF) in polyacrylamide gels to investigate the effects of glutathione on the sub-bands of serum creatine kinase (CK; EC 2.7.3.2) isoenzyme MM in acute myocardial infarction. The intensity of the "abnormal" sub-bands c (pI 7.25), e (pI 6.85), and g (pI 6.50) increased, and that of the "normal" sub-bands 1 (pI 6.91), 2 (pI 6.65), and 3 (pI 6.35) decreased, following serum incubation with reduced glutathione (GSH, final concentration 1.25 mmol/L). Further incubation with oxidized glutathione (GSSG, final concentration 5 mmol/L) reversed this change and restored the original pattern, whereas GSSG at 7.5 mmol/L caused sub-bands c, e, and g to disappear and sub-bands 1, 2, and 3 to be enhanced. Sequential incubation of serum with 2.5 mmol of GSSG and 7.5 mmol of GSH per liter produced the opposite sequence of events; i.e., the "abnormal" sub-bands disappeared then reappeared (and GSH at 10 mmol/L enhanced their reappearance). At higher concentrations, glutathione (GSH or GSSG) impaired the detection of the CK-MM sub-bands after IEF, an effect that was "quenched" by heat-inactivated serum of low CK activity. Likewise, the intensity of tissue CK-MM (corresponding to myocardium extracted into 100 mmol/L Tris HCl buffer, pH 7.4) was greatly enhanced by adding heat-inactivated serum to the tissue extract before IEF. We discuss the significance of these findings for the diagnosis of myocardial infarction.

Human serum creatine kinase kinetics following reperfusion in acute myocardial infarction

1982 ◽  
Vol 49 (4) ◽  
pp. 1033 ◽  
Author(s):  
Jeanne Y. Wei ◽  
John E. Markis ◽  
Michael Malagold ◽  
Alvin Blaustein
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Human Serum ◽  
Serum Creatine Kinase

scholarly journals -55-CHRONOLOGICAL DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION BY ANALYSIS OF SERUM CREATINE KINASE MM ISOFORMS

1986 ◽  
Vol 50 (6) ◽  
pp. 475
Author(s):  
Takahiko Kojima ◽  
Hidekazu Hashimoto ◽  
Toshio Torii ◽  
Takayuki Ito ◽  
Kouichi Ogawa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Serum Creatine Kinase
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