scholarly journals FRAGMENT-BASED DRUG DESIGN TO INHIBIT DNA METHYLTRANSFERASE 1 (DNMT1) FOR BREAST CANCER THERAPY

2019 ◽  
Vol 17 (62) ◽  
Author(s):  
Ade Hanna Natalia
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Design ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Breast Cancer Therapy ◽  
Methyltransferase 1

scholarly journals Increased Protein Stability Causes DNA Methyltransferase 1 Dysregulation in Breast Cancer

2005 ◽  
Vol 280 (18) ◽  
pp. 18302-18310 ◽  
Author(s):  
Agoston T. Agoston ◽  
Pedram Argani ◽  
Srinivasan Yegnasubramanian ◽  
Angelo M. De Marzo ◽  
Mohammad Ali Ansari-Lari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Stability ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Methyltransferase 1

Interplay between DNA Methyltransferase 1 and Micrornas During Tumorigenesis

2021 ◽  
Vol 22 ◽  
Author(s):  
Pooja Yadav ◽  
Shreetama Bandyopadhayaya ◽  
Bridget M Ford ◽  
Chandi Mandal
Keyword(s):  
Cancer Therapy ◽  
Cancer Progression ◽  
Dna Methyltransferase ◽  
Cpg Islands ◽  
Reciprocal Inhibition ◽  
Therapy Resistance ◽  
Aberrant Methylation ◽  
Dna Methyltransferase 1 ◽  
Proliferating Cells ◽  
Methyltransferase 1

Cancer is a genetic disease resulting from genomic changes, however epigenetic alterations act synergistically with these changes during tumorigenesis and cancer progression. Epigenetic variations are gaining more attraction as an important regulator in tumor progression, metastasis and therapy resistance. Aberrant DNA methylation at CpG islands is a central event in epigenetic-mediated gene silencing of various tumor suppressor genes. DNA methyltransferase 1 (DNMT1) predominately methylates at CpG islands on hemimethylated DNA substrates in proliferating cells. DNMT1 has been shown to be overexpressed in various cancer types and exhibits tumor-promoting potential. The major drawbacks to DNMT1-targeted cancer therapy are the adverse effects arising from nucleoside and non-nucleoside based DNMT1 inhibitors. This paper focuses on the regulation of DNMT1 by various microRNAs (miRNAs), which may be assigned as future DNMT1 modulators, and highlights how DNMT1 regulates various miRNAs involved in tumor suppression. Importantly, the role of reciprocal inhibition between DNMT1 and certain miRNAs in tumorigenic potential is approached with this review. Hence, this review seeks to project an efficient and strategic approach using certain miRNAs in conjunction with conventional DNMT1 inhibitors as a novel cancer therapy. It has also pinpointed to select miRNA candidates associated with DNMT1 regulation that may not only serve as potential biomarkers for cancer diagnosis and prognosis, but may also predict the existence of aberrant methylation activity in cancer cells.

Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy

2007 ◽  
Vol 85 (10) ◽  
pp. 1137-1148 ◽  
Author(s):  
Yeonjoo Jung ◽  
Jinah Park ◽  
Tai Young Kim ◽  
Jung-Hyun Park ◽  
Hyun-Soon Jong ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Targeted Inhibition ◽  
Methyltransferase 1

scholarly journals Virtual screening of natural products as an inhibitor of DNA methyltransferase 1 enzyme for breast cancer disease

2019 ◽  
Vol 509 ◽  
pp. 012052
Author(s):  
Ina Nur Istiqomah ◽  
Ahmad Husein Alkaff ◽  
Mutiara Saragih ◽  
Ade Hanna Natalia ◽  
Usman Sumo Friend Tambunan
Keyword(s):  
Breast Cancer ◽  
Natural Products ◽  
Virtual Screening ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Cancer Disease ◽  
Methyltransferase 1

scholarly journals Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. Vol. 280 (2005) 18302-18310

2005 ◽  
Vol 280 (31) ◽  
pp. 28828
Author(s):  
Agoston T. Agoston ◽  
Pedram Argani ◽  
Srinivasan Yegnasubramanian ◽  
Angelo M. De Marzo ◽  
Mohammad Ali Ansari-Lari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Stability ◽  
Dna Methyltransferase ◽  
Dna Methyltransferase 1 ◽  
Methyltransferase 1
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