scholarly journals PDA-cross-linked beta-cyclodextrin: a novel adsorbent for the removal of BPA and cationic dyes

2020 ◽  
Author(s):  
Jianyu Wang ◽  
Guang Cheng ◽  
Jian Lu ◽  
Huafeng Chen ◽  
Yanbo Zhou
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Inorganic Ions ◽  
Neutral Red ◽  
Carboxyl Groups ◽  
Stacking Interactions ◽  
Beta Cyclodextrin ◽  
Adsorption Capacities ◽  
Wide Range ◽  
Endocrine Disrupting ◽  
Adsorption Processes

Abstract In this study, 4,4′-(hexafluoroisopropene) diphthalic acid (PDA)-CD polymers containing β-cyclodextrin (CD) were synthesized for the adsorption of endocrine disrupting chemicals (EDCs) and dyes. It features great adsorption of bisphenol A (BPA), methylene blue (MB) and neutral red (NR). The maximum adsorption capacities of MB, NR and BPA can reach 113.06, 106.8 and 51.74 mg/g, respectively. The tandem adsorption results revealed that adsorptions of dyes and BPA onto PDA-CD polymer were two independent processes: non-polar BPA entrapment by cyclodextrin cavities while dyes were captured by the carboxyl groups and π-π stacking interactions. The adsorption processes performed well in a wide range of pH (4.0–10.0) and were not affected by fulvic acid (FA) and inorganic ions.

scholarly journals To Cull or Not To Cull? Considerations for Studies of Endocrine-Disrupting Chemicals

Endocrinology ◽  
2016 ◽  
Vol 157 (7) ◽  
pp. 2586-2594 ◽  
Author(s):  
Alexander Suvorov ◽  
Laura N. Vandenberg
Keyword(s):  
Laboratory Animal ◽  
Animal Studies ◽  
Metabolic Diseases ◽  
Endocrine Disrupting Chemicals ◽  
Animal Experiments ◽  
Postnatal Growth ◽  
Increased Risk ◽  
Wide Range ◽  
Endocrine Disrupting ◽  
Health Related

The power of animal models is derived from the ability to control experimental variables so that observed effects may be unequivocally attributed to the factor that was changed. One variable that is difficult to control in animal experiments is the number and composition of offspring in a litter. To account for this variability, artificial equalization of the number of offspring in a litter (culling) is often used. The rationale for culling, however, has always been controversial. The Developmental Origins of Health and Disease concept provides a new context to evaluate the pros and cons of culling in laboratory animal studies, especially in the context of endocrine-disrupting chemicals. Emerging evidence indicates that culling, especially of large litters, can drastically change the feeding status of a pup, which can result in compensatory growth with long-term consequences for the animal, including increased risk of cardio-metabolic diseases. Similarly, culling of litters to intentionally bias sex ratios can alter the animal's behavior and physiology, with effects observed on a wide range of outcomes. Thus, in an attempt to control for variability in developmental rates, culling introduces an uncontrolled or confounding variable, which itself may affect a broad spectrum of health-related consequences. Variabilities in culling protocols could be responsible for differences in responses to endocrine-disrupting chemicals reported across studies. Because litter sex composition and size are vectors that can influence both prenatal and postnatal growth, they are essential considerations for the interpretation of results from laboratory animal studies.

Intrinsic Stacking Interactions of Natural and Artificial Nucleobases

2019 ◽  
Author(s):  
Drew P. Harding ◽  
Laura J. Kingsley ◽  
Glen Spraggon ◽  
Steven Wheeler
Keyword(s):  
Gas Phase ◽  
Electrostatic Interactions ◽  
Density Functional ◽  
Molecular Descriptors ◽  
Stacking Interactions ◽  
Interaction Energies ◽  
Functional Theory ◽  
Binding Partner ◽  
Heavy Atoms ◽  
Wide Range

The intrinsic (gas-phase) stacking energies of natural and artificial nucleobases were explored using density functional theory (DFT) and correlated ab initio methods. Ranking the stacking strength of natural nucleobase dimers revealed a preference in binding partner similar to that seen from experiments, namely G > C > A > T > U. Decomposition of these interaction energies using symmetry-adapted perturbation theory (SAPT) showed that these dispersion dominated interactions are modulated by electrostatics. Artificial nucleobases showed a similar stacking preference for natural nucleobases and were also modulated by electrostatic interactions. A robust predictive multivariate model was developed that quantitively predicts the maximum stacking interaction between natural and a wide range of artificial nucleobases using molecular descriptors based on computed electrostatic potentials (ESPs) and the number of heavy atoms. This model should find utility in designing artificial nucleobase analogs that exhibit stacking interactions comparable to those of natural nucleobases. Further analysis of the descriptors in this model unveil the origin of superior stacking abilities of certain nucleobases, including cytosine and guanine.

Nanofiltration of endocrine disrupting compounds

2003 ◽  
Vol 3 (5-6) ◽  
pp. 321-327 ◽  
Author(s):  
M. Gallenkemper ◽  
T. Wintgens ◽  
T. Melin
Keyword(s):  
Wastewater Treatment ◽  
Municipal Wastewater ◽  
Wastewater Treatment Plants ◽  
Endocrine Disrupting Compounds ◽  
Municipal Wastewater Treatment ◽  
Water And Wastewater Treatment ◽  
Wide Range ◽  
Endocrine Disrupting ◽  
Municipal Wastewater Treatment Plants ◽  
Set Up

Endocrine disrupting compounds can affect the hormone system in organisms. A wide range of endocrine disrupters were found in sewage and effluents of municipal wastewater treatment plants. Toxicological evaluations indicate that conventional wastewater treatment plants are not able to remove these substances sufficiently before disposing effluent into the environment. Membrane technology, which is proving to be an effective barrier to these substances, is the subject of this research. Nanofiltration provides high quality permeates in water and wastewater treatment. Eleven different nanofiltration membranes were tested in the laboratory set-up. The observed retention for nonylphenol (NP) and bisphenol A (BPA) ranged between 70% and 100%. The contact angle is an indicator for the hydrophobicity of a membrane, whose influence on the permeability and retention of NP was evident. The retention of BPA was found to be inversely proportional to the membrane permeability.

Effect of Polyphosphate on Removal of Endocrine-Disrupting Chemicals of Nonylphenol and Bisphenol-A by Activated Carbons

2005 ◽  
Vol 40 (4) ◽  
pp. 484-490 ◽  
Author(s):  
Keun J. Choi ◽  
Sang G. Kim ◽  
Chang W. Kim ◽  
Seung H. Kim
Keyword(s):  
Activated Carbon ◽  
Bisphenol A ◽  
Surface Charge ◽  
Activated Carbons ◽  
Endocrine Disrupting Chemicals ◽  
Dipole Interaction ◽  
High Affinity ◽  
Calcium Polyphosphate ◽  
Endocrine Disrupting ◽  
Positively Charged

Abstract This study examined the effect of polyphosphate on removal of endocrine-disrupting chemicals (EDCs) such as nonylphenol and bisphenol-A by activated carbons. It was found that polyphosphate aided in the removal of nonylphenol and bisphenol- A. Polyphosphate reacted with nonylphenol, likely through dipole-dipole interaction, which then improved the nonylphenol removal. Calcium interfered with this reaction by causing competition. It was found that polyphosphate could accumulate on carbon while treating a river. The accumulated polyphosphate then aided nonylphenol removal. The extent of accumulation was dependent on the type of carbon. The accumulation occurred more extensively with the wood-based used carbon than with the coal-based used carbon due to the surface charge of the carbon. The negatively charged wood-based carbon attracted the positively charged calcium-polyphosphate complex more strongly than the uncharged coal-based carbon. The polyphosphate-coated activated carbon was also effective in nonylphenol removal. The effect was different depending on the type of carbon. Polyphosphate readily attached onto the wood-based carbon due to its high affinity for polyphosphate. The attached polyphosphate then improved the nonylphenol removal. However, the coating failed to attach polyphosphate onto the coal-based carbon. The nonylphenol removal performance of the coal-based carbon remained unchanged after the polyphosphate coating.

scholarly journals Endocrine disrupting chemicals mixture and pregnancy glucose levels among women from a fertility clinic

2019 ◽  
Vol 3 ◽  
pp. 27
Author(s):  
Bellavia A ◽  
Mínguez-Alarcón L ◽  
Ford J ◽  
Keller M ◽  
Petrozza J ◽  
...  
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Glucose Levels ◽  
Endocrine Disrupting ◽  
Fertility Clinic
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