Intensification of sonochemical degradation of phenol using additives at pilot scale operation

2011 ◽  
Vol 63 (11) ◽  
pp. 2547-2552 ◽  
Author(s):  
Ismail M. Khokhawala ◽  
Parag R. Gogate
Keyword(s):  
Sodium Chloride ◽  
Large Scale ◽  
Cupric Oxide ◽  
Scale Up ◽  
Process Intensification ◽  
Pilot Scale ◽  
Solid Particles ◽  
Solid Loading ◽  
Beneficial Effects ◽  
Operation Process

The present work reports the use of sonochemical reactors for the degradation of phenol in the presence of additives with an objective of enhancing the rates of degradation at a pilot scale operation. Process intensification studies have been carried out using additives such as hydrogen peroxide (H2O2) (0.5–2.0 g/L), sodium chloride (0.5–1.5 g/L) and solid particles viz. cupric oxide (CuO) and titanium dioxide (TiO2) (0.5–2.5 g/L). Optimum concentration for H2O2 and sodium chloride has been observed beyond which no beneficial effects are obtained even with additional loadings. Maximum extent of degradation has been observed by using ultrasound/H2O2/CuO approach at a solid loading of 1.5 g/L followed by ultrasound/H2O2/TiO2 approach at a loading of 2.0 g/L. The obtained results at pilot scale operation in the current work are very important especially due to the fact that the majority of earlier studies are at laboratory scale which cannot provide the design related information for large scale operation as required scale up ratios are quite high adding a degree of uncertainty in the design. The novelty of the present work lies in the fact that it highlights successful application of sonochemical reactors for wastewater treatment at pilot scale operation.

scholarly journals Pilot scale cavitational reactors and other enabling technologies to design the industrial recovery of polyphenols from agro-food by-products, a technical and economical overview

2018 ◽  
Author(s):  
Giancarlo Cravotto ◽  
Francesco Mariatti ◽  
Veronika Gunjevic ◽  
Massimo Secondo ◽  
Matteo Villa ◽  
...  
Keyword(s):  
Large Scale ◽  
New Technologies ◽  
Scale Up ◽  
Process Intensification ◽  
Pilot Scale ◽  
Green Technologies ◽  
Production Chain ◽  
Enabling Technologies ◽  
Key Enabling Technologies ◽  
By Products

We herein provide an overview of the most recent multidisciplinary process advances that have occurred in the food industry as a result of changes in consumer lifestyle and expectations. The demand for fresher and more natural foods is driving the development of new technologies that may efficiently operate at room temperature. Moreover, the huge amount of material discarded by the agro-food production chain lays down a significant challenge for emerging technologies that can provide new opportunities by recovering valuable by-products and creating new applications. Aiming to design industrial processes, there is a need of pilot scale plants such as the “green technologies development platform” that was established by the authors. The platform is made up of a series of multifunctional laboratories that are equipped with non-conventional pilot reactors developed in direct collaboration with partner companies in order to bridge the enormous gap between academia and industry via the large-scale exploitation of relevant research achievements. Selected key, enabling technologies for process intensification make this scale-up feasible. We make use of two selected examples, the grape and olive production chains, to show how cavitational reactors, which are based on high-intensity ultrasound and rotational hydrodynamic units, can assist food processing and the sustainable recovery of waste to produce valuable nutraceuticals as well as colouring and food-beverage additives.

scholarly journals Pilot Scale Cavitational Reactors and Other Enabling Technologies to Design the Industrial Recovery of Polyphenols from Agro-Food By-Products, a Technical and Economical Overview

Foods ◽  
2018 ◽  
Vol 7 (9) ◽  
pp. 130 ◽  
Author(s):  
Giancarlo Cravotto ◽  
Francesco Mariatti ◽  
Veronika Gunjevic ◽  
Massimo Secondo ◽  
Matteo Villa ◽  
...  
Keyword(s):  
Large Scale ◽  
New Technologies ◽  
Scale Up ◽  
Process Intensification ◽  
Pilot Scale ◽  
Green Technologies ◽  
Production Chain ◽  
Enabling Technologies ◽  
Key Enabling Technologies ◽  
By Products

We herein provide an overview of the most recent multidisciplinary process advances that have occurred in the food industry as a result of changes in consumer lifestyle and expectations. The demand for fresher and more natural foods is driving the development of new technologies that may efficiently operate at room temperature. Moreover, the huge amount of material discarded by the agro-food production chain lays down a significant challenge for emerging technologies that can provide new opportunities by recovering valuable by-products and creating new applications. Aiming to design industrial processes, there is a need for pilot scale plants such as the ‘green technologies development platform’, which was established by the authors. The platform is made up of a series of multifunctional laboratories that are equipped with non-conventional pilot reactors, developed in direct collaboration with partner companies, in order to bridge the enormous gap between academia and industry via the large-scale exploitation of relevant research achievements. Selected key, enabling technologies for process intensification make this scale-up feasible. We make use of two selected examples, the grape and olive production chains, to show how cavitational reactors, which are based on high-intensity ultrasound and rotational hydrodynamic units, can assist food processing and the sustainable recovery of waste, to produce valuable nutraceuticals as well as colouring and food–beverage additives.

scholarly journals Scale-up of a NiMoP/γAl2O3 catalyst for the hydrotreating and mild hydrocracking of heavy gasoil

2019 ◽  
Vol 74 ◽  
pp. 22 ◽  
Author(s):  
Ricardo Prada Silvy
Keyword(s):  
Scale Up ◽  
Catalyst Support ◽  
Chemical Properties ◽  
Pilot Scale ◽  
Solid Particles ◽  
Metallic Surface ◽  
Hydroxyl Groups ◽  
Alumina Surface ◽  
Distribution Profile ◽  
Surface Hydroxyl

This contribution shows the acquired experience during the scale-up of a NiMoP/γAl2O3 catalyst employed for the hydrotreating and mild hydrocracking of heavy gasoil. Three different strategies were adopted for preparing catalyst batches at pilot scale. They consisted on co-impregnation of γ-alumina extrudates with aqueous solutions containing Ni and Mo salts and phosphoric acid in one or two successive steps. The textural, chemical composition, mechanical strength, metallic surface dispersion and elemental radial distribution profile properties were influenced by the impregnation procedure employed. The co-impregnation with diluted Ni, Mo and P solutions in two successive steps is the best way to prepare the catalyst. This procedure provides a catalyst that exhibits better physico-chemical properties and catalytic activity profile than the other impregnation methods investigated. Heat and mass transfer limitations became very important when preparing catalysts in large quantities. The diffusion intra-particle and extra-particle was observed influenced by the density and viscosity properties of the metallic solution, the liquid-solid contact angle, the reactivity of phosphate, polymolybdate and phosphomolybdate species with the alumina surface hydroxyl groups, the raise of temperature produced in the solid particles during the initial impregnation step and the porosity properties of the catalyst support. It was concluded that the fine control of the metal distribution on the alumina surface during the impregnation is crucial for producing highly active uniform catalysts.

scholarly journals Heterotrophy as a tool to overcome the long and costly autotrophic scale-up process for large scale production of microalgae

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
A. Barros ◽  
H. Pereira ◽  
J. Campos ◽  
A. Marques ◽  
J. Varela ◽  
...  
Keyword(s):  
Large Scale ◽  
Scale Up ◽  
Biomass Concentration ◽  
Growth Conditions ◽  
Pilot Scale ◽  
Industrial Scale ◽  
Scale Production ◽  
Two Stage ◽  
Chlorophyll Contents ◽  
Large Scale Production

Abstract Industrial scale-up of microalgal cultures is often a protracted step prone to culture collapse and the occurrence of unwanted contaminants. To solve this problem, a two-stage scale-up process was developed – heterotrophically Chlorella vulgaris cells grown in fermenters (1st stage) were used to directly inoculate an outdoor industrial autotrophic microalgal production unit (2nd stage). A preliminary pilot-scale trial revealed that C. vulgaris cells grown heterotrophically adapted readily to outdoor autotrophic growth conditions (1-m3 photobioreactors) without any measurable difference as compared to conventional autotrophic inocula. Biomass concentration of 174.5 g L−1, the highest value ever reported for this microalga, was achieved in a 5-L fermenter during scale-up using the heterotrophic route. Inocula grown in 0.2- and 5-m3 industrial fermenters with mean productivity of 27.54 ± 5.07 and 31.86 ± 2.87 g L−1 d−1, respectively, were later used to seed several outdoor 100-m3 tubular photobioreactors. Overall, all photobioreactor cultures seeded from the heterotrophic route reached standard protein and chlorophyll contents of 52.18 ± 1.30% of DW and 23.98 ± 1.57 mg g−1 DW, respectively. In addition to providing reproducible, high-quality inocula, this two-stage approach led to a 5-fold and 12-fold decrease in scale-up time and occupancy area used for industrial scale-up, respectively.

Large Scale Production of Nanoparticles by Laser Pyrolysis

2007 ◽  
Vol 534-536 ◽  
pp. 85-88 ◽  
Author(s):  
Adrien Reau ◽  
Benoit Guizard ◽  
Cyrille Mengeot ◽  
Loic Boulanger ◽  
François Ténégal
Keyword(s):  
Large Scale ◽  
Gas Flow ◽  
Laser Intensity ◽  
Scale Up ◽  
Pilot Scale ◽  
Scale Production ◽  
Laser Pyrolysis ◽  
Quenching Effect ◽  
Wide Range ◽  
The Mean

Laser pyrolysis is a very suitable gas-phase process for the synthesis of a wide range of nanoparticles at laboratory scale. The principle of the method is based on the decomposition of gaseous or liquid reactants by a high power CO2 laser followed by a quenching effect. The literature reports the possibility to produce carbides, nitrides, oxides, metals and composites nanoparticles by this process. This paper reports a study of the effect of the laser intensity (using an innovative optical system) and of the gas flow rates on the characteristics (size and structure) of silicon carbide (SiC) nanoparticles produced at pilot scale (up to 1.13 kg/h) by using a mixture of silane (SiH4) and acetylene (C2H2). It has been shown that the decrease of the gas flow rate favors the increase of the mean grain size of the particles and that the increase of the laser intensity seems to provoke an increase of the mean crystal size and/or crystal number.

Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

2009 ◽  
Vol 2 (2) ◽  
pp. 509-516
Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Large Scale ◽  
Colloidal Particles ◽  
Scale Up ◽  
Lipid Nanoparticles ◽  
Scale Production ◽  
Research Activity ◽  
New Approach ◽  
Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

Recombinant Protein Production in Microalgae: Emerging Trends

2020 ◽  
Vol 27 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Niaz Ahmad ◽  
Muhammad Aamer Mehmood ◽  
Sana Malik
Keyword(s):  
Chloroplast Genome ◽  
Recombinant Proteins ◽  
Large Scale ◽  
Higher Plants ◽  
Scale Up ◽  
Chloroplast Transformation ◽  
Point Of View ◽  
Nuclear Transformation ◽  
Scale Production ◽  
Algal Chloroplast

: In recent years, microalgae have emerged as an alternative platform for large-scale production of recombinant proteins for different commercial applications. As a production platform, it has several advantages, including rapid growth, easily scale up and ability to grow with or without the external carbon source. Genetic transformation of several species has been established. Of these, Chlamydomonas reinhardtii has become significantly attractive for its potential to express foreign proteins inexpensively. All its three genomes – nuclear, mitochondrial and chloroplastic – have been sequenced. As a result, a wealth of information about its genetic machinery, protein expression mechanism (transcription, translation and post-translational modifications) is available. Over the years, various molecular tools have been developed for the manipulation of all these genomes. Various studies show that the transformation of the chloroplast genome has several advantages over nuclear transformation from the biopharming point of view. According to a recent survey, over 100 recombinant proteins have been expressed in algal chloroplasts. However, the expression levels achieved in the algal chloroplast genome are generally lower compared to the chloroplasts of higher plants. Work is therefore needed to make the algal chloroplast transformation commercially competitive. In this review, we discuss some examples from the algal research, which could play their role in making algal chloroplast commercially successful.

Expanding the boundaries of learning

2021 ◽  
Vol 102 (8) ◽  
pp. 8-13
Author(s):  
Thomas Hatch
Keyword(s):  
Instructional Practices ◽  
New Hampshire ◽  
Large Scale ◽  
Educational Experiences ◽  
Scale Up ◽  
Project Based Learning

Taking advantage of the possibilities for learning outside of school requires us to build on what we know about why it is so hard to sustain and scale up unconventional educational experiences within conventional schools. To illustrate the opportunities and challenges, Thomas Hatch describes a large-scale approach to project-based learning developed in a camp in New Hampshire and incorporated in a Brooklyn school, a trip-based program in Detroit, and Singapore’s systemic embrace of learning outside school. By understanding the conditions that can sustain alternative instructional practices, educators can find places to challenge the boundaries of schooling and create visions of the possible that exceed current constraints.

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