scholarly journals Problem kardiotoksyczności radioterapii raka piersi

2017 ◽  
Vol 14 (1) ◽  
pp. 16-21
Author(s):  
Anna Julia Adamska
Keyword(s):  
Heart Disease ◽  
Medical School ◽  
San Francisco ◽  
Radiation Oncology ◽  
Breast Irradiation ◽  
School Of Medicine ◽  
Brown University ◽  
American Society

Rak piersi rozpoznawany jest rocznie u ponad miliona kobiet na świecie. Zgodnie z obecnym standardem wiele z nich otrzyma złożone, wielodyscyplinarne leczenie, którego nieodłącznym elementem pozostaje radioterapia. Promieniowanie jonizujące jest znanym czynnikiem uszkadzającym serce. Wykazano, że popromienna choroba serca ( RRHD - radiation-related heart disease ) może wystąpić już po dawkach < 20Gy i ujawnić się dopiero po dłuższym okresie latencji, zwykle przekraczającym dekadę. Wielkość ryzyka RRHD wciąż nie jest dobrze poznana, wydaje się jednak, iż nie istnieje dawka progowa, poniżej której to ryzyko by nie występowało. W ostatnich latach o ryzyku powikłań kardiologicznych u pacjentek napromienianych z powodu raka piersi dyskutowano wielokrotnie; zagadnienie to pojawia się zarówno w piśmiennictwie jak i jako stały element prezentacji konferencyjnych. Poniżej spleciono ze sobą krótki przegląd piśmiennictwa z omawianego zakresu wraz ze streszczeniem bardzo interesującej prezentacji dotyczącej stanu obecnej wiedzy na temat kardiotoksyczności radioterapii  raka piersi pt. ’Cardiac Issues in Breast Irradiation’, którą przedstawił dr David E. Wazer z Tufts University School of Medicine w Bostonie oraz Alpert Medical School of Brown University w Providence na 56. Dorocznym Spotkaniu Amerykańskiego Towarzystwa Radioterapii Onkologicznej (American Society for Radiation Oncology - ASTRO)  w 2014r. w San Francisco.

Fractionation for Whole Breast Irradiation: An American Society for Radiation Oncology (ASTRO) Evidence-Based Guideline

2011 ◽  
Vol 81 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Benjamin D. Smith ◽  
Soren M. Bentzen ◽  
Candace R. Correa ◽  
Carol A. Hahn ◽  
Patricia H. Hardenbergh ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Evidence Based ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
American Society ◽  
Evidence Based Guideline

Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stage I and II Invasive Breast Cancer: American Society of Clinical Oncology Endorsement of the Society of Surgical Oncology/American Society for Radiation Oncology Consensus Guideline

2014 ◽  
Vol 32 (14) ◽  
pp. 1502-1506 ◽  
Author(s):  
Thomas A. Buchholz ◽  
Mark R. Somerfield ◽  
Jennifer J. Griggs ◽  
Souzan El-Eid ◽  
M. Elizabeth H. Hammond ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Radiation Oncology ◽  
Ad Hoc ◽  
Surgical Oncology ◽  
Breast Conserving Surgery ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Review Panel ◽  
American Society

Purpose The Society of Surgical Oncology (SSO)/American Society for Radiation Oncology (ASTRO) guideline on surgical margins for breast-conserving surgery with whole-breast irradiation in stage I and II invasive breast cancer was considered for endorsement. Methods The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing practice guidelines developed by other organizations. ASCO staff reviewed the SSO/ASTRO guideline for developmental rigor; an ASCO ad hoc review panel of experts reviewed the guideline content. Results The ASCO ad hoc guideline review panel concurred that the recommendations are clear, thorough, and based on the most relevant scientific evidence in this content area and that they present options acceptable to patients. According to the SSO/ASTRO guideline, the use of no ink on tumor (ie, no cancer cells adjacent to any inked edge/surface of specimen) as the standard for an adequate margin in invasive cancer in the era of multidisciplinary therapy is associated with low rates of ipsilateral breast tumor recurrence and has the potential to decrease re-excision rates, improve cosmetic outcomes, and decrease health care costs. Conclusion The ASCO review panel endorses the SSO/ASTRO recommendations with qualifications, as follows. The panel reinforces and amplifies the guideline authors' call for the monitoring of outcomes of the guideline at the institutional level, as institutions transition to adopting the SSO/ASTRO recommendations; would place greater emphasis on the importance of postlumpectomy mammography for cases involving microcalcifications; and calls for flexibility in the application of the guideline in light of the generally weak evidence supporting the recommendations.

scholarly journals Providing grants to attend scientific meetings

2006 ◽  
Vol 28 (5) ◽  
pp. 61
Keyword(s):  
Molecular Biology ◽  
Medical School ◽  
San Francisco ◽  
Scientific Meetings ◽  
American Society ◽  
Newcastle Upon Tyne

Catherine Arden of the William Leech Medical School, University of Newcastle upon Tyne, used a Biochemical Society Bursary to attend the American Society for Biochemistry and Molecular Biology (ASBMB) conference in San Francisco.

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