scholarly journals Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

2019 ◽  
pp. 1 ◽  
Author(s):  
Emine Arslan ◽  
Umit Gorkem ◽  
Cihan Togrul
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Maternal Serum ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Control Groups ◽  
Diabetes Mellitus Status ◽  
And Control

<p><strong>Objective:</strong> To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status.</p><p><strong>Study Design:</strong> A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment-insulin resistance were assessed.</p><p><strong>Results:</strong> In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p&lt;0.001).</p><p><strong>Conclusion:</strong> No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus.</p>

scholarly journals Effect of Diabetes Education Program on Gestational Diabetes Mellitus Knowledge Among Diabetic Pregnant Women: An Experimental Study

2020 ◽  
Author(s):  
Uchenna Cosmas Ugwu ◽  
Osmond Chukwuemeka Ene
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Education Program ◽  
Diabetes Education ◽  
Control Groups ◽  
Significant Difference ◽  
And Control ◽  
Experimental Group

Abstract Background: Gestational diabetes mellitus (GDM) is a disease condition present during pregnancy and if not properly managed would have severe effect on the maternal and neonatal health. This research determined the effect of diabetes education program (DEP) on gestational diabetes mellitus knowledge (GDMK) among diabetic pregnant women (DPW) and significant differences within groups.Methods: This study was based on a pretest – posttest measures of experimental research design involving experimental (n=110) and control (n=110) groups. A total of 220 DPW were purposively recruited from public hospitals in Nigeria between October and December 2019. The DEP was delivered to DPW in experimental group. The Gestational Diabetes Mellitus Knowledge Questionnaire (GDMKQ) of 0.774 was used for data collection. The statistical analysis was completed using IBM SPSS version 22. Results: The results revealed that no statistically significant difference existed on GDM history (P=0.801>0.05), smoking habit (P=0.0615>0.05), parity status (P=0.503>0.05), and level of education (P=0.720>0.05), while difference was observed on alcohol status (P=0.011<0.05), and age by birth (P=0.009<0.05). Also, while no significant difference existed between the DPW in the treatment and control groups on GDMK pretest measures (P=0.901>0.05), difference existed between the DPW in the intervention and control groups on GDMK posttest scores (P=0.026<0.05). Also, the higher percentage score (78%) of DPW in the experimental group in the posttest GDMK measures which is higher than the score in the pretest measures (55%) of the same group were indications that DEP has significant effect on GDMK among DPW.Conclusion: This demonstrates that reliable interventions are effective in combating pregnancy-related complications. This requires collaborative efforts by concerned bodies to combat notable complications during pregnancy using reliable intervention.Trial Registration: In retrospect, the Pan African Clinical Trial Registry documented the study with registration trial code (Trial No.: PACTR201903003187005)

scholarly journals Anti-Inflammatory Markers IL-10 and IL-35: Role in Developing Gestational Diabetes Mellitus

2020 ◽  
Author(s):  
Adele Bahar ◽  
Ozra Akha ◽  
Mahdi Bordbar ◽  
Saeid Abediankenari ◽  
Rezaali Mohammadpoor ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Inflammatory Marker ◽  
Control Group ◽  
Control Groups ◽  
The Mean ◽  
Anti Inflammatory ◽  
And Control

Introduction: Inflammatory state is considered as the pathogenesis of Gestational Diabetes Mellitus (GDM). Cytokines can cause insulin resistance and maybe the molecular basis of inflammation in Diabetes Mellitus (DM). Aim: To assess the level of Interleukin-10 (IL-10) in addition to a new anti-inflammatory cytokine marker Interleukin-35 (IL-35) in pregnant women with and without GDM. Materials and Methods: Participants in the study included 29 pregnant women with GDM (case group) and 29 healthy pregnant women (control group). Blood levels of IL-10, IL-35, Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) were measured in all participants. Independent t-test and Chi-square test were used for data analysis. Quantitative data between three gestational subgroups (<29, 29-32 and >32 weeks) in each GDM and control group were compared by ANOVA test. The p-value <0.05 was considered significant. Results: The mean levels of IL-10 were 1.03±0.85 and 0.83±0.57 pg/mL (p=0.284) and the mean IL-35 concentrations were 10.2±8.1 and 8.8±4.3 pg/mL (p=0.437) in GDM and control groups, respectively. The mean CRP and ESR levels were higher in the GDM group than the controls but the differences were not statistically significant. In the GDM group, IL-10 was significantly lower at the early stage of pregnancy (<29 weeks) compared to the later stage (>32 weeks) (p=0.04), but this was not true in the control group. There was no significant difference between the mean level of IL-35 at different gestational ages in both GDM and control groups. Conclusion: The present study showed the decreased level of anti-inflammatory marker IL-10 in the late stage of pregnancy in diabetic women especially during the last weeks of gestation. New inflammatory marker IL-35 was not statistically significant in GDM subjects.

scholarly journals Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ting Chen ◽  
Yufeng Qin ◽  
Minjian Chen ◽  
Yuqing Zhang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Alpha Diversity ◽  
16S Rrna Gene Sequencing ◽  
Maternal Serum ◽  
Rrna Gene ◽  
Child Study ◽  
Mother And Child

Abstract Background Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabolome remains incompletely understood. Methods Four hundred eighteen mothers (147 women with GDM and 271 normal pregnant women) and their neonates from the GDM Mother and Child Study were included in this study. Meconium microbiota were profiled by 16S rRNA gene sequencing. Meconium and maternal serum metabolome were examined by UPLC-QE. Results Microbial communities in meconium were significantly altered in neonates from the GDM mothers. A reduction in alpha diversity was observed in neonates of GDM mothers. At the phylum level, the abundance of Firmicutes and Proteobacteria changed significantly in neonates of GDM mothers. Metabolomic analysis of meconium showed that metabolic pathways including taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis were altered in GDM subjects. Several changed metabolites varying by the similar trend across the maternal serum and neonatal meconium were observed. Conclusion Altogether, these findings suggest that GDM could alter the serum metabolome and is associated with the neonatal meconium microbiota and metabolome, highlighting the importance of maternal factors on early-life metabolism.

scholarly journals Association of Serum Vitamin D Status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

2021 ◽  
Author(s):  
Caihong Luo ◽  
Zhiju Li ◽  
Yunya Lu ◽  
Fang Wei ◽  
Dongmei Suo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Alkaline Phosphatase ◽  
Maternal Serum ◽  
Thrombin Time ◽  
Laboratory Parameters

Abstract Background: Pregnant women develop certain metabolic alterations and substantial nutrient insufficiency, which may impact fetus development. Reports on the association of serum 25-hydroxy vitamin D (25(OH)D, VD) status with gestational diabetes mellitus (GDM) is still controversial. This study aimed to investigate the association of serum VD status with GDM and other laboratory parameters in early pregnant women.Methods: A total of 1516 pregnant women were enrolled in this study. Maternal serum VD and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. Serum VD level was subsequently correlated with blood glucose and other laboratory parameters.Results: The average VD concentration was 59.12 ± 12.5 nmol/L. None of the study subjects had VD <25 nmol/L; 434 (28.6%) women had VD <50 nmol/L, and 200 women (13.2%) had VD ≥75 nmol/L. There were 264 (17.4%) women diagnosed with GDM. There was not, however, a correlation between serum VD and GDM in early pregnancy. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum VD levels. There was a positive correlation between serum VD and pre-albumin, activated partial thromboplastin time, and a negative correlation between serum VD, creatinine, and thrombin time.Conclusions: There was no correlation between maternal serum VD and GDM in early pregnant women. There were, however, associations between serum VD and parity, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factors, which need further study to explain their pathophysiology and clinical significance.

scholarly journals First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

2019 ◽  
Vol 16 (19) ◽  
pp. 3654 ◽  
Author(s):  
Federica Visconti ◽  
Paola Quaresima ◽  
Eusebio Chiefari ◽  
Patrizia Caroleo ◽  
Biagio Arcidiacono ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Maternal Serum ◽  
Fetal Aneuploidy ◽  
Combined Test ◽  
Β Hcg

Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM.

scholarly journals Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Seishi Furukawa ◽  
Yoichi Kobayashi
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Insulin Secretion ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Impaired Insulin Secretion ◽  
Impaired Insulin

Aim. To identify the involvement of leanness and impaired insulin secretion with Japanese gestational diabetes mellitus (GDM). Method. A cross-sectional study was conducted comprising 219 at-risk pregnant women who underwent a 75g glucose tolerance test at a single institute in Tokyo, Japan. We identified GDM and normal glucose tolerance (NGT). The cut-off value of the homeostasis model assessment insulin resistance (HOMA-IR) for detecting GDM was determined. The GDM group was divided into subgroups according to insulin resistance based on the cut-off value of HOMA-IR. We compared the prepregnancy body mass index (BMI) and homeostasis model assessment of β-cell function (HOMA-β) between the group comprising low insulin resistance (LIR) and the group comprising high insulin resistance (HIR). Results. Seventy GDM cases and 149 NGT cases were identified. By using receiver operating characteristic curve analysis, the HOMA-IR cut-off value was determined to be 1.41. Twenty-five GDM cases (36%) were classified as LIR and forty-five GDM cases (64%) were classified as HIR. The background including indications for having 75gOGTT and the gestational age having 75gOGTT did not differ between groups. The BMI of the LIR group was significantly lower than that of the HIR group (20.9±2.8 vs. 24.4 ± 5.5, p<0.01), and the HOMA-β of the LIR group was significantly lower than that of the HIR group (95.5±30.3 vs. 146.0±70.1, p<0.01). A positive linear correlation was found between BMI and HOMA-β in cases of GDM (r=0.27, p=0.02). Conclusion. Leanness with impaired insulin secretion is deeply involved in Japanese gestational diabetes mellitus.

scholarly journals Altered Maternal Serum Dynamic Thiol-Disulfide Interchange Reactions in Pregnant Women with Gestational Diabetes Mellitus

2016 ◽  
pp. 1-6 ◽  
Author(s):  
Melahat Yıldırım ◽  
Esengül Türkyılmaz ◽  
Büşra Demir Cendek ◽  
Gülcan Dauletkazin ◽  
Murta Alışık ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Maternal Serum ◽  
Interchange Reactions

scholarly journals Changes of Serum Adiponectin and Glycated Albumin Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance

2020 ◽  
Author(s):  
Qingju WANG ◽  
Juan DU ◽  
Fenglian LIU
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Glycated Albumin ◽  
Serum Adiponectin ◽  
Control Group ◽  
Childbearing Age ◽  
And Control

Background: We aimed to investigate the changes of serum adiponectin and glycated albumin (GA) levels in gestational diabetes mellitus patients and their relationship with insulin resistance. Methods: Overall, 137 pregnant women were enrolled from Jinan City People's Hospital, Laiwu District, China from Jan 2015 to Jun 2018. Among them, 71 pregnant women with gestational diabetes mellitus were examined as diabetes group, and 66 normal pregnant women as normal pregnant women group. In addition, 58 normal non-pregnant women of childbearing age who were examined in our hospital during the same period were selected as a control group. The serum adiponectin and GA levels of the three groups were compared, and the relationship between serum adiponectin, GA levels and insulin resistance was analyzed. Results: The serum adiponectin level of pregnant women in gestational diabetes mellitus (GDM) group was significantly lower than that of normal pregnant women and control group (P=0.031, P=0.027). The serum GA level of pregnant women in GDM group was significantly higher than that of normal pregnant women and control group (P<0.001). Pearson correlation analysis showed that GA was positively correlated with Fasting plasma glucose (FPG), Fasting insulin (FINS) and Insulin resistance index(HOMA-IR) levels (P<0.001), while adiponectin was negatively correlated with FPG FINS and HOMA-IR levels (P<0.001). Conclusion: Abnormal levels of serum GA and adiponectin are closely related to insulin resistance in patients with gestational diabetes mellitus. Detection of serum GA and adiponectin levels can diagnose gestational diabetes mellitus quickly and effectively.

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