scholarly journals Endometrial Volume, and Sub-Endometrial Blood Flow Indices as Predictors of ICSI Success

2018 ◽  
Vol 24 (1) ◽  
pp. 27
Author(s):  
Wessam M. Abuelghar ◽  
Abdelatif G. Elkholy ◽  
Ibrahim A. Abdelazim ◽  
Ihab Serag ◽  
Kahaled I Abdallah ◽  
...  
Keyword(s):  
Power Doppler ◽  
3D Ultrasound ◽  
Clinical Pregnancy ◽  
Transvaginal Sonography ◽  
Flow Index ◽  
3D Power Doppler ◽  
Endometrial Volume ◽  
The Difference ◽  
Β Hcg ◽  
Vascularization Index

<p><strong>Objective:</strong> This study designed to evaluate the endometrial volume, and the sub-endometrial flow indices as predictors of ICSI success.</p><p><strong>Study Design:</strong> Fifty infertile women included in this study, and received long pituitary downregulation protocol followed by hMG controlled hyperstimulation until ≥ 3 ovarian follicles 18-20 mm in diameter detected. Ovulation triggered by hCG, followed by oocytes retrieval 34-36 hours after hCG trigger. Day 2 or 3 embryo transfers done for all studied women, followed by quantitative β-hCG 14 days after the embryo transfers, and transvaginal sonography to diagnose clinical pregnancy. Studied women evaluated by the 3D ultrasound, and 3D power Doppler angiography at the day of the embryo transfers to assess the endometrial volume, and the sub-endometrial flow indices as predictors of the ICSI success.</p><p><strong>Results:</strong> The endometrial volume, sub-endometrial vascularization index, flow index, and vascularization flow index were higher in successful ICSI compared to unsuccessful ICSI group, but the difference was not significant. The ROC analysis showed that the endometrial volume and the 3D power Doppler angiography parameters (vascularization index, flow index, and vascularization flow index indices) were not conclusive for prediction of successful clinical pregnancy after the current ICSI trials.</p><p><strong>Conclusion:</strong> The endometrial volume and the 3D power Doppler angiography indices were not predictive for the clinical pregnancy after the current ICSI trials.</p>

scholarly journals Three-Dimensional Power Doppler Analysis of Cerebral Circulation in Normal and Growth-Restricted Fetuses

2009 ◽  
Vol 29 (9) ◽  
pp. 1609-1618 ◽  
Author(s):  
Jose L Bartha ◽  
Eva M Moya ◽  
Blas Hervías-Vivancos
Keyword(s):  
Doppler Ultrasound ◽  
Cerebral Circulation ◽  
Pulsatility Index ◽  
Power Doppler ◽  
Three Dimensional ◽  
Flow Index ◽  
Power Doppler Ultrasound ◽  
3D Power Doppler ◽  
Doppler Indices ◽  
Vascularization Index

The objective of the present study was to evaluate fetal cerebral circulation by using three-dimensional (3D) power Doppler ultrasound in normal and growth-restricted fetuses. A total of 100 normal grown fetuses were compared with other 25 with growth restriction (FGR). Three-dimensional power Doppler ultrasound was used to assess fetal cerebral 3D vascular indices: vascularization index, flow index (FI), and vascularization flow index (VFI). Both FI and VFI correlated positively with gestational age. On average, all the 3D vascular indices were increased in fetuses with FGR. The proportion of fetuses detected as having hemodynamic redistribution was higher when using 3D power Doppler indices than by means of the middle cerebral artery pulsatility index (52% versus 20%, P = 0.002). In conclusion, two of the three indices increased during gestation. All the fetal cerebral 3D vascular indices are increased in fetuses with FGR. In these fetuses, there were more cases suggesting hemodynamic redistribution than expected by conventional Doppler studies.

Role of 3D and 3D Power Doppler to Assess Endometrial Receptivity in IUI Cycles

2010 ◽  
Vol 1 (1) ◽  
pp. 19-24
Author(s):  
Chaitanya B Nagori
Keyword(s):  
Color Doppler ◽  
Randomized Study ◽  
Power Doppler ◽  
3D Ultrasound ◽  
Endometrial Receptivity ◽  
Key Factors ◽  
3D Power Doppler ◽  
Volume Assessment ◽  
Endometrial Volume

ABSTRACT Background The assessment of the endometrial receptivity at the time of human chorionic gonadotrophin (hCG) is one of the key factors for success of all ART procedures. Aim To assess, if 3D and 3D power Doppler assessment of endometrial receptivity before giving hCG, helps improving pregnancy rates in superovulation with IUI cycles. Settings and Design A prospective randomized study of 2500 cycles of IUI was done over a period of twelve months for pre-hCG endometrial assessment. Method Endometrial assessment was done on Voluson 730 Expert, (Wipro GE) using transvaginal multifrequency volume probe 5 to 9 MHz. When follicles and endometrium were considered mature by 2D US and color Doppler, 3D and 3D power Doppler assessment of the endometrium was done before giving hCG. These values were evaluated for conception and nonconception groups. Results Conception rates were higher, when endometrial volume was between 3 and 7 cc. In our study, we have found endometrial FI > 20 and endometrial VFI > 40 as most optimum. Conclusions 3D ultrasound is accurate for volume assessment of endometrium. 3D and 3D PD, when used with 2D US and color Doppler for pre-hCG endometrial assessment, it would definitely improve implantation rates in IUI cycles.

Second-Trimester Placental Volume and Vascular Indices in the Prediction of Small-for-Gestational-Age Neonates

2014 ◽  
Vol 37 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Shih-Wen Fang ◽  
Chia-Yu Ou ◽  
Ching-Chang Tsai ◽  
Hung-Chun Fu ◽  
Hsin-Hsin Cheng ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Power Doppler ◽  
Body Height ◽  
3D Ultrasound ◽  
Flow Index ◽  
Second Trimester ◽  
3D Power Doppler ◽  
Placental Volume

Objective: To evaluate the ability of second-trimester placental volume and vascular indices to predict small-for-gestational-age (SGA) birth weight pregnancies. Material and Methods: Women with singleton pregnancies were prospectively evaluated at 17-20 weeks of gestation. Second-trimester placental volume and vascular indices were obtained and calculated using volume organ computer-aided analysis and three-dimensional (3D) power Doppler ultrasound. Participants were followed until delivery and their medical records were reviewed, including maternal age, parity and pregestational body weight and body height, as well as the gestational age, birth weight and gender of the fetus. Results: Of the 163 women with complete follow-up, 20 gave birth to SGA and 143 to appropriate-for-gestational-age (AGA) neonates. The mean second-trimester placental volume was significantly lower in the SGA than in the AGA group (170.6 ± 49.8 vs. 213.5 ± 75.8 cm3, p = 0.015). None of the vascular indices, including the vascularization index, flow index and vascularization flow index, differed significantly between the two groups. We also found that the optimum cutoff for placental volume at a gestational age of 17-18 weeks was 189.7 cm3. Discussion: Second-trimester placental volume was positively correlated with neonatal birth weight. Second-trimester placental volume measured on 3D ultrasound may be predictive of SGA neonates.

scholarly journals Influence of Ulipristal Acetate in 3D-PW-Doppler parameters of patients with uterine myomas: a prospective observational pilot study

2020 ◽  
pp. 11-18
Author(s):  
Patricia Diaz Ortega ◽  
García-Manero Manuel
Keyword(s):  
Power Doppler ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
3D Ultrasound ◽  
Benign Tumors ◽  
Ulipristal Acetate ◽  
End Of Treatment ◽  
3D Power Doppler ◽  
Multiple Treatments ◽  
Vascularization Index

Introduction: uterine fibroids are the most common benign tumors of the female genital tract. They associate a varied symptomatology, from the absence of symptoms to more disabling bleeding or pain [1,2]. There are multiple treatments directed against different targets such as ulipristal acetate which has proven effective in reducing the size of the fibroids and their symptoms [7]. Our preliminary study seeks to find the relationship between ulipristal acetate and angiogenesis of uterine fibroids, by measuring ultrasound vascularization of the fibroid throughout the treatment. Material and Methods: A prospective observational study has been designed, in which 24 patients with symptomatic uterine fibroids have been included and given 4 cycles of Ulipristal Acetate. The size and vascularization of the fibroids were measured at the beginning and end of treatment; as well as on several occasions throughout the follow-up. Myoma vascularization was measured by power doppler 3D ultrasound through different parameters that define the vascularization in a more objective way: Vascularization Index (VI), Flow Rate (FR), Flow Vascularization Index (FVI). Result: A significant reduction in the size of the fibroids has been observed, as well as their vascularization in terms of vascularization indices measured by 3D PW ultrasound. These changes were evident at the end of treatment and were maintained over time. Conclusion: There is a correlation between myoma vascularization and treatment with Ulipristal Acetate. SPRMs may provide effective treatment for women with symptomatic fibroids by two ways: supports selective progesterone receptor modulators and reduced angiogenesis. In addition, the use of vascularization markers of 3DPW ultrasound and the colour map allow us to monitor the response to medical treatment of myomas in a non-invasive and easily reproducible way. Keywords: Ulipristal Acetate; Esmya®; Uterine fibroids; Angiogenesis; 3D Power Doppler Ultrasound

scholarly journals 2D and 3D Power Doppler Ultrasound of Endometrium as Implantation Marker

2008 ◽  
Vol 2 (2) ◽  
pp. 1-11 ◽  
Author(s):  
Santiago Bau ◽  
Luis T Mercé ◽  
María J Barco
Keyword(s):  
Sagittal Plane ◽  
Endometrial Thickness ◽  
Power Doppler ◽  
3D Ultrasound ◽  
Single Measurement ◽  
3D Power Doppler ◽  
Endometrial Pattern ◽  
Reproductive Techniques ◽  
Endometrial Volume ◽  
2D And 3D

Abstract Transvaginal ultrasonography has an important role in assessing the endometrium. With 2DUS, a single measurement of endometrial thickness in the sagittal plane is widely used in assisted reproductive technology and in pregnancy prediction. Endometrial volume, measured with 3DUS, has been studied as a potentially more accurate parameter. The endometrial pattern was related to the likelihood of implantation. This pattern correlated in a positive fashion with subsequent implantation. 3D ultrasound and 3D power Doppler parameters have been applied to assisted reproductive techniques as outcome predictors, although studies are still scarce, they show very promising results.

scholarly journals Evaluation and correlation of placental vasculature by three-dimensional power Doppler ultrasonography with umbilical Doppler in normal and IUGR pregnancies

2018 ◽  
Vol 7 (9) ◽  
pp. 3818
Author(s):  
Sumesh Choudhary ◽  
Vineet Mishra ◽  
Rohina Aggarwal ◽  
Kavita Mistry
Keyword(s):  
Gestational Age ◽  
Pulsatility Index ◽  
Doppler Ultrasonography ◽  
Power Doppler ◽  
Three Dimensional ◽  
Flow Index ◽  
P Value ◽  
Power Doppler Ultrasonography ◽  
3D Power Doppler ◽  
Placental Volume

Background: In recent years there have been significant developments in the use of 3D Power Doppler (3DPD) imaging and quantitative 3DPD histogram analysis to estimate both placental volume and intraplacental vasculature. This study is to evaluate the distribution and variation of placental vascular indices according to gestational age and placental volume and position. Co relate the umbilical Doppler indices with placental vascular indices.Methods: From September 2016 to October 2017, three-dimensional (3D)-power Doppler ultrasound was performed in 200 singalton pregnancies from 20 to 40 weeks of gestation. Using the same pre-established settings for all patients, power Doppler was applied to the placenta and placental volume was obtained by the rotational technique (VOCAL). The 3D-power histogram was used to determine the placental vascular indices: vascularization index (VI), flow index (FI) and vascularization-flow index (VFI). Umbilical Doppler was measured on the free loop of umbilical cord. The placental vascular indices were then plotted against gestational age placental volume, position and umbilical Doppler SD ratio, PI and RI. These values were evaluated in IUGR fetus.Results: Analysis of the results showed that the placental vascular indices estimated by 3D-power Doppler ultrasonography presented constant distribution throughout gestation despite the significant increase in placental volume. Placental position at fundal region shows higher value of VI, FI, and VFI. Placental position with relation to VI, FI, and VFI shows statistically significant with p value <0.01. Placental vascular indices VI, FI and VFI when corelated with systolic/ diastolic ratio, pulsatility index and resistive resistance index of umbilical artery shows poor negative correlation, only VI and FI shows statistically significant with SD ratio as p value is <0.01and <0.04. VFI did not show statistically significant as p value is 0.10(NS). With pulsatility index p value is statistically significant is less than<0.01 with vascular indices. Resistive index p value is statistically significant is less than <0.01 for VI and VFI but not significant with FI as p value is 0.06.Conclusions: Doppler ultrasound assists in the evaluation of placental vascularization in normal and IUGR pregnancies, may play an important role in future research on fetoplacental insufficiency.

scholarly journals Role of Three Dimensional Doppler Ultrasonography And Leukemia Inhibitory Factor From Endometrial Secretion In Predicting Clinical Pregnancy In IVF Treatment

2021 ◽  
Author(s):  
Ivan Sini ◽  
Nining Handayani ◽  
Ph.D Hara Alida MD ◽  
Arief Boediono ◽  
Budi Wiweko ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Leukemia Inhibitory Factor ◽  
Protein Concentration ◽  
Power Doppler ◽  
Three Dimensional ◽  
Endometrial Receptivity ◽  
Clinical Pregnancy ◽  
Inhibitory Factor ◽  
Flow Index

Abstract PurposeThis study aimed to evaluate the potential synergistic role of three-dimensional power Doppler angiography ultrasound and the expression of Leukemia Inhibitory factor (LIF) protein in predicting the endometrial receptivity of fresh In Vitro Fertilization (IVF) cycles. Materials and methods This prospective study involved 29 good prognosis women who underwent fresh IVF cycles with fresh blastocysts transfer. Serial measurements of sub-endometrial parameters via power Doppler angiography including vascularity index (VI), flow index (FI), and vascularization flow index (VFI) were conducted consecutively on the day of oocyte maturation trigger, ovum pick-up, and blastocyst transfer. Aspiration of endometrial secretion was performed on the day of embryo transfer. ResultsAfter performing multiple logistic regression analyses, the mean index of VI on the trigger day and LIF protein concentration at the window of implantation was significantly higher in clinically pregnant women than that of the non-pregnant women (p <0.05). The area under the curve (AUC) of LIF concentration was shown to have a powerful predictive value to forecast clinical pregnancy (0.884, p <0.05), with a cut-off value of 713 pg/mL. Likewise, VI index on the trigger day was adequate to become a predictor for the pregnancy event (AUC 0.803, the cut-off value >5.381, p<0.05). A combination of both variables utilizing the cut-off value was adequate for the differentiation of pregnant and non-pregnant cases (p <0.05). ConclusionVI index assessed on trigger day and the expression of LIF protein concentration at the window of implantation provided sufficient information to predict endometrial receptivity.

Factors Associated with Placental Vascularization Measured by 3D Power Doppler Ultrasonographic Sphere Biopsy between 11 and 14 Weeks of Gestation

2018 ◽  
Vol 35 (10) ◽  
pp. 964-971 ◽  
Author(s):  
Amelie Boutin ◽  
Regina Dembickaja ◽  
Mercedes Campanero ◽  
Kypros Nicolaides ◽  
Suzanne Demers
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gestational Age ◽  
Maternal Age ◽  
Power Doppler ◽  
First Trimester ◽  
Flow Index ◽  
Crown Rump Length ◽  
Nulliparous Women ◽  
3D Power Doppler

Objective Preeclampsia is associated with placental vascularization disorders. Ultrasonographic sphere biopsy (USSB) of the placenta can estimate the vascularization of the placenta and potentially the risk of preeclampsia. We aimed to explore the factors related to placental vascularization measured with USSB in the first trimester. Study Design A prospective cohort was conducted in women recruited at 11 to 14 weeks. Three-dimensional acquisition of the placenta with power Doppler was undertaken along with crown-rump length (CRL). Using USSB of the full placental thickness at its center, vascularization index, flow index, and vascular flow index were measured. Pearson's correlation coefficients and multivariate linear regression were used to correlate the vascularization indices with CRL and maternal characteristics. Results A total of 5,612 women were recruited at a mean gestational age of 12.8 ± 0.6 weeks. We observed that vascularization indices increase with CRL. After adjustment, we observed that maternal age, ethnicity other than Caucasian, and body mass index were associated with lower vascularization indices, while diabetes, smoking, and assisted reproduction technology were not. We observed that parous women without history of preeclampsia had greater vascularization indices compared with nulliparous women. Conclusion Placental vascularization indices assessed by USSB fluctuate with gestational age, ethnicity, maternal age, body mass index, and previous pregnancy history.

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