scholarly journals Therapy for Locally Advanced Heptocellular Carcinoma, Role of Anti-Angiogenesis.

2011 ◽  
Vol 7 (Issue 3-4) ◽  
pp. 1-4
Author(s):  
Mahmoud Abdelsalam
Keyword(s):  
Locally Advanced ◽  
Heptocellular Carcinoma

scholarly journals The Role of Surgery in Lung Cancer Treatment: Present Indications and Future Perspectives—State of the Art

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3711
Author(s):  
François Montagne ◽  
Florian Guisier ◽  
Nicolas Venissac ◽  
Jean-Marc Baste
Keyword(s):  
Lung Cancer ◽  
Residual Disease ◽  
State Of The Art ◽  
Locally Advanced ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Screening Programs ◽  
Systemic Therapies

Non-small cell lung cancers (NSCLC) are different today, due to the increased use of screening programs and of innovative systemic therapies, leading to the diagnosis of earlier and pre-invasive tumors, and of more advanced and controlled metastatic tumors. Surgery for NSCLC remains the cornerstone treatment when it can be performed. The role of surgery and surgeons has also evolved because surgeons not only perform the initial curative lung cancer resection but they also accompany and follow-up patients from pre-operative rehabilitation, to treatment for recurrences. Surgery is personalized, according to cancer characteristics, including cancer extensions, from pre-invasive and local tumors to locally advanced, metastatic disease, or residual disease after medical treatment, anticipating recurrences, and patients’ characteristics. Surgical management is constantly evolving to offer the best oncologic resection adapted to each NSCLC stage. Today, NSCLC can be considered as a chronic disease and surgery is a valuable tool for the diagnosis and treatment of recurrences, and in palliative conditions to relieve dyspnea and improve patients’ comfort.

scholarly journals The Emerging Role of Robotics in Pelvic Exenteration Surgery for Locally Advanced Rectal Cancer: A Narrative Review

2021 ◽  
Vol 10 (7) ◽  
pp. 1518
Author(s):  
Tou Pin Chang ◽  
Aik Yong Chok ◽  
Dominic Tan ◽  
Ailin Rogers ◽  
Shahnawaz Rasheed ◽  
...  
Keyword(s):  
Pelvic Exenteration ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Invasive Approach ◽  
Perioperative Morbidity ◽  
Rectal Cancers ◽  
Beyond Tme ◽  
Assisted Technologies

Pelvic exenteration surgery for locally advanced rectal cancers is a complex and extensive multivisceral operation, which is associated with high perioperative morbidity and mortality rates. Significant technical challenges may arise due to inadequate access, visualisation, and characterisation of tissue planes and critical structures in the spatially constrained pelvis. Over the last two decades, robotic-assisted technologies have facilitated substantial advancements in the minimally invasive approach to total mesorectal excision (TME) for rectal cancers. Here, we review the emerging experience and evidence of robotic assistance in beyond TME multivisceral pelvic exenteration for locally advanced rectal cancers where heightened operative challenges and cumbersome ergonomics are likely to be encountered.

scholarly journals Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer?

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 946
Author(s):  
Richard Partl ◽  
Katarzyna Lukasiak ◽  
Bettina Stranz ◽  
Eva Hassler ◽  
Marton Magyar ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anal Verge ◽  
Locally Advanced ◽  
Multivariable Analysis ◽  
Sphincter Preservation ◽  
Independent Predictive Factor ◽  
Lymphocyte Ratio ◽  
Inflammatory Parameters ◽  
Pre Treatment

There is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present cohort study was to investigate the association between inflammation-based parameters and the sphincter-preserving surgery rate in patients with low-lying locally advanced rectal cancer (LARC). A total of 848 patients with LARC undergoing radiotherapy from 2004 to 2019 were retrospectively reviewed in order to identify patients with rectal cancer localized ≤ 6 cm from the anal verge, treated with neo-adjuvant radiochemotherapy (nRCT) and subsequent surgery. Univariable and multivariable analyses were used to investigate the role of pre-treatment inflammatory parameters, including the C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the prediction of sphincter preservation. A total of 363 patients met the inclusion criteria; among them, 210 patients (57.9%) underwent sphincter-preserving surgery, and in 153 patients (42.1%), an abdominoperineal rectum resection was performed. Univariable analysis showed a significant association of the pre-treatment CRP value (OR = 2.548, 95% CI: 1.584–4.097, p < 0.001) with sphincter preservation, whereas the pre-treatment NLR (OR = 1.098, 95% CI: 0.976–1.235, p = 0.120) and PLR (OR = 1.002, 95% CI: 1.000–1.005, p = 0.062) were not significantly associated with the type of surgery. In multivariable analysis, the pre-treatment CRP value (OR = 2.544; 95% CI: 1.314–4.926; p = 0.006) was identified as an independent predictive factor for sphincter-preserving surgery. The findings of the present study suggest that the pre-treatment CRP value represents an independent parameter predicting the probability of sphincter-preserving surgery in patients with low-lying LARC.

PD-0413: The role of different chemotherapy protocols for concurrent CRT in locally advanced NSCLC

2020 ◽  
Vol 152 ◽  
pp. S223-S224
Author(s):  
E. Gkika ◽  
S. Tanja ◽  
K. Stephanie ◽  
A. Schaefer-Schuler ◽  
M. Mix ◽  
...  
Keyword(s):  
Advanced Nsclc ◽  
Locally Advanced ◽  
Locally Advanced Nsclc

scholarly journals Role of induction chemotherapy in locally advanced T4b oral cavity cancers: A single Institute experience

2017 ◽  
Vol 28 ◽  
pp. v385
Author(s):  
K.N. Lokesh ◽  
T. Chaudhuri ◽  
K.C. Lakshmaiah ◽  
G. Babu ◽  
D. Lokanatha ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Induction Chemotherapy ◽  
Locally Advanced ◽  
Oral Cavity Cancers

Locally advanced gallbladder cancer: a review of the criteria and role of imaging

2020 ◽  
Author(s):  
Pankaj Gupta ◽  
Kesha Meghashyam ◽  
Yashi Marodia ◽  
Vikas Gupta ◽  
Rajender Basher ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Locally Advanced ◽  
Advanced Gallbladder Cancer
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