scholarly journals Prognostic and Predictive Value of P53, Bcl2, Rb and Egfr for Bladder Preservation in Invasive Bladder Carcinoma Treated by Trimodality Approach

2011 ◽  
Vol 7 (Issue 1-2) ◽  
pp. 40-49 ◽  
Author(s):  
Samy Al Gizaw ◽  
Hoda Essa ◽  
Abeer Refaiy ◽  
Gehan Elosaily
1995 ◽  
Vol 62 (2) ◽  
pp. 163-167
Author(s):  
G. Mobilio

Bladder tumours are generally grouped as superficial or invasive because of their different therapeutical regimens. Superficial tumours still cause uncertainties in choosing the best treatment due to their heterogeneity and different behaviour. In the prevision of these tumours it is important to consider all the factors that could influence the prognosis: tumoral characteristics, grading and staging mistakes, effects of the therapy and immunological response. Moreover it is important for clinical studies to have appropriate end points. Prognostic factors and markers with high predictive value can allow specific treatment for the individual cases to be planned.


2001 ◽  
Vol 165 (1) ◽  
pp. 42-46 ◽  
Author(s):  
S. BERNARDINI ◽  
C. BILLEREY ◽  
M. MARTIN ◽  
G.L. ADESSI ◽  
H. WALLERAND ◽  
...  

2000 ◽  
Vol 46 (5) ◽  
pp. 1213-1221 ◽  
Author(s):  
Claus Rödel ◽  
Gerhard G Grabenbauer ◽  
Franz Rödel ◽  
Stefan Birkenhake ◽  
Reinhard Kühn ◽  
...  

2021 ◽  
Vol 6 (11) ◽  

Over the last two decades, there has been a significant evolution of the complex treatment of the invasive bladder carcinoma (BC), including both surgery methods and high-tech radiotherapy (RT), often combined with chemotherapy (Ch). Different protocols supporting multimodal treatment and the concept of the bladder preservation are currently developed. New high-tech radiation methods were presented combined with Ch to preserve the bladder as a healing alternative to radical cystectomy. The purpose of this overview is to present the place and healing effect of high-tech RT in the contemporary treatment approach to invasive BC. The expected contributions from this research project are: 1) For the first time in Bulgaria, modern bladder-sparing strategies combine maximal transurethral resection of bladder tumor (TURBT) followed by an induction course of concurrent radiation therapy (RT) and sensitizing chemotherapy will be held. 2) Disease-free survival, overall survival, local control and early radical toxicity in two patient groups after self intensity modulated radiation therapy (IMRT) and after concurrent chemoradiotherapy (CChRT) with VMAT will be analyzed. It is important to improve the quality of life by preserving the bladder in the invasive bladder carcinoma.


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