Regenerative Capacity of Allogenic Gingival Margin-Derived Stem Cells with Fibrin Glue on Albino Rats Partially Dissected Submandibular Salivary Glands

2016 ◽  
Vol 3 (12) ◽  
pp. 37-41
Keyword(s):  
Stem Cells ◽  
Salivary Glands ◽  
Fibrin Glue ◽  
Albino Rats ◽  
Regenerative Capacity ◽  
Gingival Margin ◽  
Submandibular Salivary Glands

Experimental enlargement of submandibular salivary glands of rats

1960 ◽  
Vol 199 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Herbert Wells ◽  
Paul L. Munson
Keyword(s):  
Salivary Glands ◽  
Control Level ◽  
Dry Weight ◽  
Detectable Effect ◽  
Incisor Tooth ◽  
Lower Incisor ◽  
Gingival Margin ◽  
Adjacent Mucosa ◽  
Data Support ◽  
Submandibular Salivary Glands

An increase of 12% in fresh and dry weight of the submandibular salivary glands was observed 24 hours after a single amputation of the lower incisor teeth. The effect of repeated amputations was increased by increasing the frequency of amputations and by lengthening the period of amputations. After cessation of a series of amputations, the weight of the hypertrophied salivary glands decreased gradually to approach the control level. Repeated amputation of only one lower incisor tooth was much less effective than amputation of both, and the effect was largely but not entirely restricted to the ipsilateral glands. Ulceration of the adjacent mucosa without amputation of the incisors had no detectable effect on the salivary glands. After amputation of the tips of the incisor teeth without exposure of the pulp or after half-amputations with minimum exposure, the salivary glands increased in weight significantly but much less than after amputation at the gingival margin. It is concluded that the data support the reflex neurological explanation of the phenomenon previously offered by the authors.

Increase in weight of the submandibular salivary glands of rats following periodic amputation of the erupted portion of the incisor teeth

1959 ◽  
Vol 196 (4) ◽  
pp. 827-830 ◽  
Author(s):  
Herbert Wells ◽  
S. Jerome Zackin ◽  
Paul Gold-Haber ◽  
Paul L. Munson
Keyword(s):  
Salivary Glands ◽  
Chronic Treatment ◽  
Dry Weight ◽  
Albino Rats ◽  
Submandibular Glands ◽  
Submandibular Salivary Glands ◽  
Starting Point ◽  
Lower Incisors

Periodic amputation of the erupted portion of the lower incisors of albino rats resulted in a marked increase in the wet and dry weight of the submandibular salivary glands as early as 7 days after the first amputation. Enlargement of both serous and mucous acini was observed, but no effect on the cells of the tubules could be detected. Amputation of the upper incisors alone did not result in enlargement of the submandibular glands. Hypophysectomy decreased the extent of the response to amputation of the lower incisors but did not abolish it. Chronic treatment with cortisone had no significant effect on the weight of the glands. A reflex neurologic explanation was offered as a tentative basis for understanding the phenomenon and as a starting point for further investigation.

scholarly journals Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

2021 ◽  
Vol 8 (12) ◽  
pp. 219
Author(s):  
Mahmoud M. Bakr ◽  
Mahmoud M. Al-Ankily ◽  
Sara M. Shogaa ◽  
Mohamed Shamel
Keyword(s):  
Vitamin E ◽  
Salivary Glands ◽  
Antioxidant Properties ◽  
Antimicrobial Properties ◽  
Nano Particles ◽  
Control Group ◽  
Albino Rats ◽  
Immune Reactivity ◽  
Immunohistochemical Markers ◽  
Submandibular Salivary Glands

Silver nanoparticles (AgNPs) are extensively used in many industries due to their superior antimicrobial properties. However, it is evident from many studies that AgNPs has cytotoxic potential through its effect on excessive formation of reactive oxygen species (ROS). The aim of this study was to examine the toxic effect of AgNPs on the submandibular salivary glands and the attenuating effect of vitamin E, as a natural antioxidant, against this toxicity. Thirty Albino rats were divided into 3 groups (n = 10): control group, AgNPs group receiving 2 mg/kg daily for 28 days, and AgNPs and vitamin E group receiving AgNPs the same as the previous group in addition to vitamin E at a dose of 100 mg/kg. Microscopic, ultrastructural, and cytokeratin immune-reactivity examination of the glands were performed. The AgNPs group showed noticeable degeneration in all structures of the gland as evident in the histological and ultrastructural examination. The AgNPs and vitamin E group revealed an improvement of the glandular elements. A significant increase in cytokeratin immune expression was found after comparison of both groups (p = 0.01). This current study shows that vitamin E has powerful antioxidant properties, which can combat the cytotoxic effect caused by AgNPs. Further studies are deemed necessary to confirm this finding using other immunohistochemical markers, such as myosin and E-cadherin.

Sign in / Sign up

Export Citation Format

Share Document