Therapeutic Effects of Milk Thistle Extract against Renal Toxicity Induced By Diethylnitrosamine and Carbon Tetrachloride in Adult Rats

2017 ◽  
Vol 10 (1) ◽  
pp. 107-124
Author(s):  
Amal. Ahmed ◽  
Abeer Hassanin ◽  
Abeer Hassan ◽  
Saadia Ali ◽  
A. El-Anwar
Keyword(s):  
Carbon Tetrachloride ◽  
Renal Toxicity ◽  
Milk Thistle ◽  
Therapeutic Effects ◽  
Adult Rats

scholarly journals Curative Role of Dithiophenolato Titanium (IV)-Chitosan Nanocomposite Complex Against Carbon Tetrachloride-Induced Liver Injuries

2021 ◽  
Author(s):  
Nadia Z Shaban ◽  
Salah A Yehiaa ◽  
Doaa Awad ◽  
Shaban Y Shaban ◽  
Samar R Saleh
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Lipid Profile ◽  
Hepg2 Cell ◽  
Chitosan Nanoparticles ◽  
Antibacterial Activities ◽  
Therapeutic Effects ◽  
Liver Histopathology ◽  
Liver Injuries ◽  
Kidney Functions

Abstract Background Titanium-based compounds have been incorporated as promising antineoplastic metals. In our previous studies, dithiophenolato titanium (IV) Complex "DBT" and its chitosan nanocomposite "DBT-CSNPs" were prepared and we showed that these compounds have antibacterial activities, cytotoxic, and have abilities to bind with DNA helixes. Therefore, in this study, we evaluated the LD50 values of dithiophenolato titanium (IV)-complex (DBT) and its high thermal stable chitosan nanoparticles (DBT-CSNPs). Then their therapeutic effects against liver injuries induced by carbon tetrachloride (CCl4) were assessed and compared with cisplatin treatment. Additionally, the anti-proliferative activity of DBT and DBT-CSNPs against human liver cancer (HepG2) cell lines through the analysis of the cell cycle was evaluated. Methods Nine groups of rats were prepared: normal, DBT, DBT-CSNPs, CSNPs, CCl4, CCl4-DBT, CCl4-DBT-CSNPs, CCl4-CSNPs and CCl4-cisplatin. Liver histopathology and the biochemical markers involving oxidative stress, apoptosis, liver and kidney functions, and lipid profile were determined. Results The results revealed that the treatment with DBT-CSNPs and DBT after CCl4 administration abolished liver damage since it reduced the apoptosis induced by CCl4 via the reduction of DNA fragmentation, Bax and caspase- 8 with an elevation of Bcl2 and Bcl2/Bax ratio. Also, these treatments caused nonsignificant changes in the markers of oxidative stress. Therefore, liver histopathology and functions, lipid profile, and kidney functions were improved. Cisplatin treatment reduced liver injury with a degree less than DBT-CSNPs and DBT, but it induced nephrotoxicity. Administration of DBT-CSNPs and DBT to healthy rats for 14 days has no adverse effect. Also, the results showed that DBT-CSNPs and DBT inhibited the proliferation of HepG2 cells by arresting cells in the G2/M phase and inducing cell death. Conclusion DBT-CSNPs and DBT have a therapeutic effect against CCl4-induced liver injuries via the reduction of apoptosis induced by CCl4. Moreover, both compounds have antineoplastic activities against the HepG2 cell line. In all cases, DBT-CSNPs have a greater effect due to their nanostructure. Therefore, both compounds can be used in the pharmacological fields, particularly DBT-CSNPs.

Protective and Therapeutic Effects of Curcuma xanthorrhiza on Hepatotoxin-induced Liver Damage

1995 ◽  
Vol 23 (03n04) ◽  
pp. 243-254 ◽  
Author(s):  
Song-Chow Li ◽  
Chun-Ching Lin ◽  
Yun-Ho Lin ◽  
S. Supriyatna ◽  
Chao-Wei Teng
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Intraperitoneal Administration ◽  
Therapeutic Effects ◽  
Acute Liver Damage ◽  
Liver Injuries ◽  
Acute Elevation ◽  
Serum Transaminases ◽  
Hepatoprotective Agent ◽  
Curcuma Xanthorrhiza

Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.

scholarly journals Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Celice C. Souza ◽  
Michelle Castro da Silva ◽  
Rosana Telma Lopes ◽  
Marcelo M. Cardoso ◽  
Lucas Lacerda de Souza ◽  
...  
Keyword(s):  
Apoptotic Cell ◽  
Cresyl Violet ◽  
Bone Marrow Mononuclear Cell ◽  
Histopathological Analysis ◽  
Therapeutic Effects ◽  
Apoptotic Cells ◽  
Therapeutic Approaches ◽  
Adult Rats ◽  
Minocycline Treatment ◽  
Active Caspase

We explored the comparative effects of minocycline treatment and intrastriatal BMMC transplantation after experimental striatal stroke in adult rats. Male Wistar adult rats were divided as follows: saline-treated (N=5), minocycline-treated (N=5), and BMMC-transplanted (N=5) animals. Animals received intrastriatal microinjections of 80 pmol of endothelin-1 (ET-1). Behavioral tests were performed at 1, 3, and 7 days postischemia. Animals were treated with minocycline (50 mg/kg, i.p.) or intrastriatal transplants of 106 BMMCs at 24 h postischemia. Animals were perfused at 7 days after ischemic induction. Coronal sections were stained with cresyl violet for gross histopathological analysis and immunolabeled for the identification of neuronal bodies (NeuN), activated microglia/macrophages (ED1), and apoptotic cells (active caspase-3). BMMC transplantation and minocycline reduced the number of ED1+ cells (p<0.05, ANOVA-Tukey), but BMMC afforded better results. Both treatments afforded comparable levels of neuronal preservation compared to control (p>0.05). BMMC transplantation induced a higher decrease in the number of apoptotic cells compared to control and minocycline treatment. Both therapeutic approaches improved functional recovery in ischemic animals. The results suggest that BMMC transplantation is more effective in modulating microglial activation and reducing apoptotic cell death than minocycline, although both treatments are equally efficacious on improving neuronal preservation.

Therapeutic Effects of CD133+ in the Carbon Tetrachloride (CCl4) Induced Chronic Liver Dysfunction in Rat Model

2015 ◽  
Vol 11 (4) ◽  
pp. 359-365
Author(s):  
Manouchehr Safari ◽  
Laya Ghahari ◽  
Katayoun Safari ◽  
Mahmoodreza Madadian ◽  
Mohammad Reza Aldaghi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Rat Model ◽  
Liver Dysfunction ◽  
Chronic Liver ◽  
Therapeutic Effects

High-dose ifosfamide in relapsed pediatric osteosarcoma: Therapeutic effects and renal toxicity

2005 ◽  
Vol 44 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Su G�ls�n Berrak ◽  
Margaret Pearson ◽  
Semha Berbero?lu ◽  
?nci Erg�rhan ?lhan ◽  
Norman Jaffe
Keyword(s):  
Renal Toxicity ◽  
High Dose ◽  
Therapeutic Effects ◽  
Pediatric Osteosarcoma
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