EFFECT OF CROISSANT SUPPLEMENTED WITH HONEY AND PROPOLIS ON ASPIRIN-INDUCED STOMACH ULCERATION IN RATS

2015 ◽  
Vol 6 (3) ◽  
pp. 177-191
Author(s):  
A. Zeiny ◽  
A. Shalaby ◽  
Fatima Zemzemi ◽  
Omnia Awad
Keyword(s):  
Stomach Ulceration

Prophylaxis by vitamin C in starvation induced rat stomach ulceration

Life Sciences ◽  
1974 ◽  
Vol 14 (11) ◽  
pp. 2209-2214 ◽  
Author(s):  
Carl D. Cheney ◽  
Eric Rudrud
Keyword(s):  
Vitamin C ◽  
Rat Stomach ◽  
Stomach Ulceration

Effect of fucoidan on aspirin-induced stomach ulceration in rats

2010 ◽  
Vol 183 (1) ◽  
pp. 249-254 ◽  
Author(s):  
Jong-il Choi ◽  
Hanumatha Rao Balaji Raghavendran ◽  
Nak-Yun Sung ◽  
Jae-Hun Kim ◽  
Byeong Soo Chun ◽  
...  
Keyword(s):  
Stomach Ulceration

Gastroprotective properties ofMyristica malabaricaagainst indometacin-induced stomach ulceration: a mechanistic exploration

2007 ◽  
Vol 59 (11) ◽  
pp. 1555-1565 ◽  
Author(s):  
Debashish Banerjee ◽  
Biswanath Maity ◽  
Ajay K. Bauri ◽  
Sandip K. Bandyopadhyay ◽  
Subrata Chattopadhyay
Keyword(s):  
Stomach Ulceration

scholarly journals Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Biplab Adhikary ◽  
Sudhir Kumar Yadav ◽  
Kshama Roy ◽  
Sandip K. Bandyopadhyay ◽  
Subrata Chattopadhyay
Keyword(s):  
Total Antioxidant Status ◽  
Black Tea ◽  
Total Antioxidant ◽  
Histopathological Studies ◽  
Oxidative Effects ◽  
Antioxidative Action ◽  
Stomach Ulceration ◽  
Cox 1 ◽  
Plasma Total Antioxidant Status ◽  
Glandular Portion

The healing activities of black tea (BT) and the theaflavins (TF) against the indomethacin-induced stomach ulceration were studied in a mouse model. Indomethacin (18 mg/kg, p.o.) administration induced maximum ulceration in the glandular portion of the gastric mucosa on the 3rd day, accompanied by increased lipid peroxidation and protein oxidation, depletion of thiol-defense and mucin, as well as reduced expressions of cyclooxygenases (COX) and prostaglandin (PG) E synthesis in the gastric tissues, and plasma total antioxidant status of mice. Treatment with BT (40 mg/kg), TF (1 mg/kg), and omeprazole (3 mg/kg) produced similar (74%–76%) ulcer healing, as revealed from the histopathological studies. Treatment with all the above samples reversed the adverse oxidative effects of indomethacin significantly. BT and TF also enhanced the PGE synthesis by augmenting the expressions of COX 1 and 2, but did not modulate acid secretion.

scholarly journals Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Konstantin V. Kudryavtsev ◽  
Anna O. Markevich ◽  
Oleksandr V. Virchenko ◽  
Tetyana M. Falalyeyeva ◽  
Tetyana V. Beregova ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Small Molecule ◽  
Water Immersion ◽  
Gastroprotective Activity ◽  
Oxidative Balance ◽  
Antioxidant Profile ◽  
Physicochemical Methods ◽  
Derivatives Of ◽  
Stomach Ulceration

This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluatedin vivoat water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1 mg/kg treatment with (2-hydroxyphenyl)thioacetyl derivatives ofL-lysine andL-proline efficiently decreases up to 86% stress-induced stomach ulceration in rats. Discovered small-molecule antiulcer agents modulate activities of gastric mucosa tissue superoxide dismutase, catalase, and xanthine oxidase in concerted directions. Gastroprotective effect of (2-hydroxyphenyl)thioacetyl derivatives ofL-lysine andL-proline at least partially depends on the correction of gastric mucosa oxidative balance.

Decrease Of Platelet Aggregation In Rats Under Gastric Ulcer-Causing Stress

1981 ◽  
Author(s):  
T Terano ◽  
T Hamazaki ◽  
A Hirai ◽  
Y Tamura ◽  
A Kumagai
Keyword(s):  
Gastric Ulcer ◽  
Platelet Aggregation ◽  
Room Temperature ◽  
Platelet Rich Plasma ◽  
Water Immersion ◽  
Ether Anesthesia ◽  
Normal Rat ◽  
Antiaggregatory Activity ◽  
Stomach Ulceration ◽  
Rat Platelets

Decreased platelet aggregability may play an important role in gastric ulcer continuation. We attempted to identify an antiaggregatory substance involved in stress induced gastric ulceration in rats. METHODS: 1) Male SD rats (180-220g) were stressed by water immersion, one group for 30 min and another for 120 min. Platelet rich plasma (PRP) and platelet poor plasma (PPP) were obtained from stressed rats and normal rats under ether anesthesia. Platelet aggregation was carried out by addition of 1/10 vol of 50μM ADP and was measured using a Sienco aggregometer. 2) Platelet-plasma mixing experiments. PRP from normal rats and from rats stressed for 30 min was centrifuged and the supernatant was discarded. Packed platelets from normal rats were resuspended in PPP from stressed rats and platelets from stressed rats were resuspended in PPP from normal rats. Also, platelets from each rat were resuspended in PPP of the same rat. Aggregation was then observed. 3) Stability tests of the activity in PPP from stressed rats which depressed platelet aggregation. PPP from normal and stressed rats was stored for 4. hr either in ice or at room temperature. Platelets from a normal rat were then mixed with each PPP. 4) 6 keto PGF1α was measured by RIA. RESULTS: 1) The aggregability of rat platelets was decreased to 1/4-1/5 and to 1/10 of the normal value, after 30 min and 120 min stress, respectively. 2) Normal platelets suspended in PPP from stressed rats did not aggregate. Platelets from stressed rats suspended in normal PPP showed significant aggregability. 3) The antiaggregatory activity of PPP from stressed rats was lost significantly after storage at room temperature for 4 hr, while storage in ice did not greatly affect this activity. DISCUSSION: During water immersion stress which causes stomach ulceration of rats there appear platelet antiaggregatory substance(s) in plasma. Like PGI2, the substance observed in this experiment is more stable at 0°C than at room temperature. However, plasma 6 keto PGF1αconcentrations in stressed rats did not increase enough to explain the decreased platelet aggregation. Identification of this antiaggregatory substance is now under way.

Stomach ulceration and emotionality in selected strains of rats

1965 ◽  
Vol 8 (4) ◽  
pp. 477-479 ◽  
Author(s):  
A.A. Mikhail ◽  
P.L. Broadhurst
Keyword(s):  
Stomach Ulceration
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