scholarly journals CROSS NEUTRALIZATION OF SOME KINDS OF SCORPION VENOMS FROM AFRICA AND SOUTH EAST USING VACSERA POLYVALENT SCORPION ANTISERA

2019 ◽  
Vol 49 (2) ◽  
pp. 443-449
Author(s):  
ABIR ELFIKY ◽  
HODA ATTIA ◽  
MOAAZ ABD ELAZIZ
Keyword(s):  
Scorpion Venoms ◽  
Cross Neutralization

scholarly journals B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

Cell ◽  
2021 ◽  
Author(s):  
Johannes F. Scheid ◽  
Christopher O. Barnes ◽  
Basak Eraslan ◽  
Andrew Hudak ◽  
Jennifer R. Keeffe ◽  
...  
Keyword(s):  
B Cell ◽  
Cross Neutralization

scholarly journals Identification of Two Cross-Neutralizing Linear Epitopes within the L1 Major Capsid Protein of Human Papillomaviruses

2002 ◽  
Vol 76 (13) ◽  
pp. 6480-6486 ◽  
Author(s):  
Alba-Lucia Combita ◽  
Antoine Touzé ◽  
Latifa Bousarghin ◽  
Neil D. Christensen ◽  
Pierre Coursaget
Keyword(s):  
Neutralizing Antibodies ◽  
Polyclonal Antibodies ◽  
Human Papillomaviruses ◽  
Hpv 16 ◽  
Human Papillomavirus Type 16 ◽  
Linear Epitopes ◽  
Cross Neutralization ◽  
Definition Of ◽  
L1 Protein

ABSTRACT The neutralizing activities of polyclonal antibodies and monoclonal antibodies (MAbs) obtained by immunization of mice with L1 virus-like particles (VLPs) were investigated by using pseudovirion infectivity assays for human papillomavirus type 16 (HPV-16), HPV-31, HPV-33, HPV-45, HPV-58, and HPV-59 to obtain a better definition of cross-neutralization between high-risk HPVs. In this study, we confirmed and extended previous studies indicating that most genital HPV genotypes represent separate serotypes, and the results suggest that the classification of serotypes is similar to that of genotypes. In addition, three cross-neutralizing MAbs were identified (HPV-16.J4, HPV-16.I23, and HPV-33.E12). MAb HPV-16.J4 recognized a conserved linear epitope located within the FG loop of the L1 protein, and HPV-16.I23 recognized another located within the DE loop. The results suggested that reactivity of MAb HPV-16.I23 to L1 protein is lost when leucine 152 of the HPV-16 L1 protein is replaced by phenylalanine. This confirmed the existence of linear epitopes within the L1 protein that induce neutralizing antibodies, and this is the first evidence that such linear epitopes induce cross-neutralization. However, the cross-neutralization induced by L1 VLPs represents less than 1% of the neutralizing activity induced by the dominant conformational epitopes, and it is questionable whether this is sufficient to offer cross-protection in vivo.

scholarly journals Cross-neutralization of influenza A viruses mediated by a single antibody loop

Nature ◽  
2012 ◽  
Vol 489 (7417) ◽  
pp. 526-532 ◽  
Author(s):  
Damian C. Ekiert ◽  
Arun K. Kashyap ◽  
John Steel ◽  
Adam Rubrum ◽  
Gira Bhabha ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza A Viruses ◽  
Cross Neutralization

Venom proteome of Bungarus sindanus (Sind krait) from Pakistan and in vivo cross-neutralization of toxicity using an Indian polyvalent antivenom

2019 ◽  
Vol 193 ◽  
pp. 243-254 ◽  
Author(s):  
Angeline Mei Feng Oh ◽  
Choo Hock Tan ◽  
Kae Yi Tan ◽  
Naeem H. Quraishi ◽  
Nget Hong Tan
Keyword(s):  
Cross Neutralization

scholarly journals Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies

2021 ◽  
Vol 12 ◽  
Author(s):  
Chengchao Ding ◽  
Jun He ◽  
Xiangyu Zhang ◽  
Chengcheng Jiang ◽  
Yong Sun ◽  
...  
Keyword(s):  
Immune Response ◽  
Monoclonal Antibodies ◽  
Humoral Immune Response ◽  
Immune Escape ◽  
Spike Protein ◽  
Single Amino Acid ◽  
Humoral Immune ◽  
Cross Neutralization ◽  
Altered Sensitivity ◽  
Single Amino Acid Mutation

Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial mutations in spike protein that escape humoral immune response, we evaluated the cross-neutralization of convalescent plasmas and RBD-specific monoclonal antibodies (mAbs) against various spike protein-based pseudoviruses. Three of 24 SARS-CoV-2 pseudoviruses containing different mutations in spike protein, including D614G, A475V, and E484Q, consistently showed an altered sensitivity to neutralization by convalescent plasmas. A475V and E484Q mutants are highly resistant to neutralization by mAb B38 and 2-4, suggesting that some crucial mutations in spike protein might evolve SARS-CoV-2 variants capable of escaping humoral immune response.

scholarly journals RBD206-sc-dimer induced robust cross-neutralization against SARS-CoV-2 and variants of concern

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Chuge Zhou ◽  
Xiaodong Zai ◽  
Ziqing Zhou ◽  
Ruihua Li ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Cross Neutralization

scholarly journals Erratum: Structural basis of potent Zika–dengue virus antibody cross-neutralization

Nature ◽  
2016 ◽  
Vol 539 (7628) ◽  
pp. 314-314 ◽  
Author(s):  
Giovanna Barba-Spaeth ◽  
Wanwisa Dejnirattisai ◽  
Alexander Rouvinski ◽  
Marie-Christine Vaney ◽  
Iris Medits ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Structural Basis ◽  
Virus Antibody ◽  
Cross Neutralization
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